Keywords: A1AT; α1-antitrypsin (A1AT); ALB; albumin; BMP-2; bone morphogenetic protein 2; BSA; bovine serum albumin; DAPI; 4',6-diamidino-2-phenylindole; BMP-4; bone morphogenic protein 4; DE; definitive endoderm; DMEM-HG; Dubelcco's modified Eagle's medium-high
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Keywords: REEs; rare earth elements; REO; rare earth oxides; PG; phosphogypsum; PHH; hemihydrate phosphogypsum; PDH; dihydrate phosphogypsum; DH; dihydrate process; HH; hemihydrate process; HDH; hemi-dihydrate process; HRC; hemi-dihydrate recrystallization process;
Keywords: 2D-sw; 2D-sandwich; AMI; amiodarone; APAP; acetaminophen; BA; bile acid; BC; bile canaliculi; BOS; bosentan; BSEP; bile salt export pump; CPZ; chlorpromazine; CSA; cyclosporine A; CYP450; cytochrome P450; DIC; drug-induced cholestasis; DICI; drug-induced
Keywords: ADR; Adriamycin; BD; Brownian dynamics; CG; Coarse-grained; CMC; Critical micelle concentration; CUDA; Compute unified device architecture; DDFT; Dynamic density functional theory; DFT; Density functional theory; DLS; Dynamic light scattering; DMFT; Dynam
Keywords: Extracellular matrix; Human embryonic stem cell; Human induced pluripotent stem cell; Hepatic differentiation; Laminin-511; Laminin-521; ACM; acellular matrix; Act A; Activin A; AAT; alpha-1 antitrypsin; AFP; alpha fetoprotein; ALB; albumin; AhR; aryl hyd
Keywords: DBP; diastolic blood pressure; HDL; high density lipoprotein; HH; Healthy Hearts study; MetS; metabolic syndrome; MetSSS; metabolic syndrome severity score; PHH; Protecting Healthy Hearts study; SBP; systolic blood pressure; Trigs; triglycerides; QoL; qua
Keywords: AMI; amiodarone; MDEA; mono-N-desethylamiodarone; DDEA; di-N-desethylamiodarone; PHH; primary human hepatocytes; CYP; cytochrome P450; DMSO; dimetylsulfoxide; MeOH; methanol; HMM; Hepatocyte Maintenance Medium; FCS; fetal calf serum; SW; sandwich; d0; day
Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MSE
Keywords: 5C-AKB48; N-(1-adamantyl)-1-(5-chloropentyl)-1H-indazole-3-carboxamide; AMB-CHMICA; methyl 2-{[1-(cyclohexylmethyl)-1H-indol-3-yl]formamido}-3-methylbutanoate; CCS; collision cross section; HEPES; N-2-hydroxyethylpiperazine-N-2-ethane sulfonic acid; IMS;
Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction
Keywords: VPA; valproic acid; PHH; primary human hepatocytes; HDAC; histone deacetylase; AOP; adverse outcome pathway; MeDIP; Methylated DNA Immunoprecipitation; PSW-ANOVA; Probe Sliding Window-ANOVA; DMR; differential methylated regions; DMG; differentially methyl
Metabolism of the synthetic cannabinoid 5F-PY-PICA by human and rat hepatocytes and identification of biliary analytical targets by directional efflux in sandwich-cultured rat hepatocytes using UHPLC-HR-MS/MS
Keywords: AAUC; Area under the curve; CB; Cannabinoid receptors; CDFDA; 5-(6)-carboxy-2â²,7â²-dichlorofluorescein diacetate; DMEM; Dulbecco's modified Eagle's medium; EGTA; Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; FBS; Fetal bovi
Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems
Keywords: HLCs; Antiviral; Primary Isolates; Personalized Medicine; ALB; albumin; AFP; alpha-fetoprotein; bFGF; basic fibroblast growth factor; BM; basal medium; CsA; cyclosporine A; DE; definitive endoderm; DMSO; dimethyl sulfoxide; Dox; doxycycline; ESC; embryoni
Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein
Keywords: Hepatitis E; PLC/PRF/5 Cells; Infectious Particles; ORF2 Products; aa; amino acid; Ag; antigen; BFA; brefeldin A; DMEM; Dulbecco's modified Eagle's medium; DT; sodium deoxycholate and trypsin treatment; ER; endoplasmic reticulum; ffu; focus forming un
cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation
Keywords: α-SMA; alpha smooth muscle actin; cGKI; cGMP-dependent protein kinase I; cGKI-SM; cGKI-smooth muscle rescue mice; ECM; extracellular matrix; HSC; hepatic stellate cell; IPA; Ingenuity Pathway Analysis; MMP; matrix metallopeptidase; NAFLD; non-alcoholic f
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
Keywords: Ac-DEVD-AMC; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin; AKT; protein kinase B; AMP; ampicillin; ATB; antibiotic; ATF6; activating transcription factor 6; BC; bile canaliculi; BSEP; bile salt export pump; CDF; 5(6)-carboxy-2,7-dichlorofluorescein;
Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies
Keywords: Microfluidics; Hepatocytes; Micropatterned Co-Cultures; Spheroids; Bioprinting; Cellular Microarrays; BAL; bioartificial liver; CRP; C-reactive protein; CYP450; cytochrome P450; DILI; drug-induced liver injury; ECM; extracellular matrix; HSC; hepatic stel
Human-based systems: Mechanistic NASH modelling just around the corner?
Keywords: Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a
Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines
Keywords: ACN; acetonitrile; BCA; bicinchoninic acid; DMSO; dimethyl sulfoxide; ESI; electrospray ionization; HPLC; high pressure liquid chromatography; iPSC; induced pluripotent stem cell; LDA; low density array; MS; mass spectrometry; P450; cytochrome P450; PCA;
Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes
Keywords: Exosomes; Escape; Virology; Rab27a; DMV; double-membrane vesicle; dsRNA; double-stranded RNA; EVs; extracellular vesicles; gt; genotype; HAV; hepatitis A virus; HCV; hepatitis C virus; HCVcc; cell culture derived HCV; IFIT1 or 3; interferon-induced protei
HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon
Keywords: Coinfection; Interferon-stimulated Gene; PRR; RIG-I; APOBEC; apolipoprotein B mRNA editing enzyme catalytic subunit; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; circDNA; circular DNA; GFP-IRF3; green fluorescent protein-interferon
Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice
Keywords: ALT; Alanine aminotransferase; ActD; Actinomycin D; CYP; Cytochrome P450; CQ; Chloroquine; Drp1; Dynamin-related protein 1; DHPAs; Dehydropyrrolizidine alkaloids; DHR; dehydroretronecine; EM; Electron microscopy; GSH; Glutathione; GAPDH; Glyceradehyde-3-p
Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors
Keywords: UDPGA; 5â²-diphosphoglucuronic acid; CRMs; chemically reactive metabolites; CYP; cytochrome P450; HLM; human liver microsomes; PHH; primary human hepatocytes; UGTs; UDP-glucuronosyltransferases; β-estradiol (PubChem CID:5757); Chenodeoxycholic acid (Pub
Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5â²AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long
Research ArticleHepatitis B virus induces RNR-R2 expression via DNA damage response activation
Keywords: HBV; hepatitis B virus; dNTPs; deoxyribonucleotide triphosphates; Chk1; checkpoint kinase 1; RNR; ribonucleotide reductase; DDR; DNA damage response; PHH; primary human hepatocytes; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; qRT-
Research ArticleExpression and functionality of Toll- and RIG-like receptors in HepaRG cells
Keywords: PHH; primary human hepatocyte; TLR; toll-like receptor; RIG-I; retinoic acid-inducible gene 1; RLR; RIG-like receptor; RT; reverse transcription; qPCR; quantitative polymerase chain reaction; FACS; fluorescence-activated cell sorting; IL-6; interleukin-6;
Interleukin 6 inhibits HBV entry through NTCP down regulation
Keywords: HBV; Hepatitis B virus; NTCP; Sodium taurocholate co-transporting polypeptide; IL-6; Interleukin 6; IFN γ; Interferon gamma; ALT; Alanine aminotransferase; TNFα; Tumor Necrosis Factor alpha; IL-1β; Interleukin 1 beta; OSM; Oncostatin M; PHH; Primary Hu
Urinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project
Keywords: PAH; polycyclic aromatic hydrocarbon; 1-HP; 1-hydroxypyrene; PHh; hydroxyphenanthrene; SPE; solid phased extraction; HPLC-FD; high resolution liquid chromatography with fluorimetric detection; LOQ; limit of quantification; LOD; limit of detection; GM; geo
Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing
Keywords: AD; adefovir dipivoxil; AhR; aryl hydrocarbon receptor; AMIO; amiodarone; APAP; acetaminophen; ATF4; activating transcription factor 4; CAA; chloroacetaldehyde; CdCl2; cadmium chloride; ChIP-seq; chromatin immunoprecipitation followed by DNA sequencing; C
Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment
Keywords: EZ; ezetimibe; RCT; reverse cholesterol transport; Abcg5/g8; Abcg5 and Abcg8; KO; knock-out; WT; wild-type; PHH; primary human hepatocytes; CDCA; chenodeoxycholic acid; BMM; bone marrow macrophages; TICE; trans-intestinal cholesterol excretion; Npc1l1; At
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Keywords: AFB; aflatoxin B1; AhR; aryl hydrocarbon receptor; APAP; acetaminophen; BaP; benzo(α) pyrene; BMD; benchmark dose; BNA; Bayesian network analysis; BPDE; benzo(a) pyrene diolepoxide; CDKN1A; cyclin-dependent kinase inhibitor 1A; cDNA; copy DNA; CES; criti
Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes
Keywords: Species Specificity; Virology; Virus Entry; Myrcludex B; cccDNA; covalently closed circular DNA; DMSO; dimethyl sulfoxide; h; human; HBcAg; hepatitis B core antigen; HBeAg; hepatitis B e antigen; HBsAg; hepatitis B surface antigen; HBV; hepatitis B virus;
Research ArticleHBV core promoter mutations promote cellular proliferation through E2F1-mediated upregulation of S-phase kinase-associated protein 2 transcription
Keywords: CP; core promoter; HCC; hepatocellular carcinoma; HBx; hepatitis B virus X-protein; TA variant; A1762T/G1764A variant; Combo variant; T1753A/A1762T/G1764A/T1768A variant; WT; wild type; SKP; S-phase kinase-associated protein; PHH; primary human hepatocyte
EROD activity induction in peripheral blood lymphocytes, liver and brain tissues of rats orally exposed to polycyclic aromatic hydrocarbons
Keywords: BSA; Bovine Serum Albumin; CYP; cytochrome P450 oxygenase; EROD; ethoxyresorufin-O-deethylase; PAH; polycyilc aromatic hydrocarbons; PBL; peripheral blood lymphocytes; PBS; phosphate buffer saline; PHH; polycyclic halogenated hydrocarbons; US-EPA; United
Human Type 2 Myeloid Dendritic Cells Produce Interferon-λ and Amplify Interferon-α in Response to Hepatitis C Virus Infection
Keywords: IL-28B SNP; NK Cells; NKT Cells; Viral Immune Regulation; BDCA; blood DC antigen; CpG; cytosine-phosphate-guanosine; CXCL; CXC-chemokine ligand; DC; dendritic cell; dsRNA; double-strand RNA; HCV; hepatitis C virus; HCVcc; cell culture-derived hepatitis
HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons
Keywords: IRF; Cytokine; IL29; Nonresponder; ELISA; enzyme-linked immunosorbent assay; HCVcc; hepatitis C virus cell culture; IFN; interferon; IL; interleukin; ISG; interferon-stimulated gene; MOI; multiplicity of infection; PAMP; pathogen-associated molecular patt
Interferon-γ-Stimulated Genes, but Not USP18, Are Expressed in Livers of Patients With Acute Hepatitis C
Keywords: HCV; Jak-STAT Signaling; Host-Virus Interaction; Immune Response; AHC; acute hepatitis C; CHC; chronic hepatitis C; CHC-NR; CHC nonresponder; CHC-R; CHC responder; HCV; hepatitis C virus; HPF; high-power field; ISG; interferon-stimulated gene; JAK; Ja
Augmenter of liver regeneration (ALR) protects human hepatocytes against apoptosis
Keywords: rhALR; recombinant human augmenter of liver regeneration; EGF; epidermal growth factor; ERK-1/2; extracellular signal-regulated kinase 1/2; FCS; fetal calf serum; HGF; hepatocyte growth factor; LPS; lipopolysaccharide; MAP kinase; mitogen-activated prot
Research ArticleHepatitis B virus X protein is essential to initiate and maintain virus replication after infection
Keywords: HBV; hepatitis B virus; HBx; hepatitis B virus X protein; PHH; primary human hepatocytes; cccDNA; covalently closed circular DNA; ChIP; chromatin immunoprecipitation; Hepatitis B virus; HBx protein; Natural infection; Primary human hepatocytes; HepaRG;
How Valid is the AHRQ Patient Safety Indicator “Postoperative Hemorrhage or Hematoma”?
Keywords: AHRQ; Agency for Healthcare Research and Quality; CMS; Centers for Medicare and Medicaid Services; EMR; electronic medical record; FP; False positive; OR; operating room; PHH; postoperative hemorrhage or hematoma; PPV; positive predictive value; PSI; Pati
Hepatitis B Virus Core Promoter Mutations Contribute to Hepatocarcinogenesis by Deregulating SKP2 and Its Target, p21
Keywords: Liver Cancer; Genetics; Virology; Tumorigenesis; BrdU; 5-bromo-2â²-deoxyuridine; combo mutant; T1753A/A1762T/G1764A/T1768A mutant; CP; core promoter; HBx; hepatitis B virus X protein; PHH; primary human hepatocyte; SCF; SKP1/CUL1/F-box ubiquitin ligase c
Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner
Keywords: Augmenter of liver regeneration; Human hepatocytes; Liver regeneration; AKT/PKB; ERK1/2; Liver specificity; AP-1; activator protein-1; rhALR; recombinant human augmenter of liver regeneration; EGF; epidermal growth factor; ERK1/2; extracellular signal-reg
Seizures in Extremely Low Birth Weight Infants Are Associated with Adverse Outcome
Keywords: aEEG; Amplitude-integrated EEG; ANS; Antenatal steroids; BPD; Bronchopulmonary dysplasia; BW; Birth weight; CNS; Central nervous system; CP; Cerebral palsy; CPR; Cardiopulmonary resuscitation; EEG; Electroencephalography; ELBW; Extremely low birth weight;
Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis
Keywords: ACSL5; acyl-CoA synthetase long chain isoform 5; TNFα; Tumor necrosis factor alpha; TRAIL; TNFα related apoptosis inducing ligand; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; CMV; cytomegalievirus; CamR; chloramphenico
Production of Infectious Hepatitis C Virus in Primary Cultures of Human Adult Hepatocytes
Keywords: Antiviral Drug Assay; Cell Permissiveness; Hepatocellular Physiology; Virus Propagation; ApoB; apolipoprotein B; CYP; cytochrome P450; ffu; focus-forming units; HCVcc; hepatitis C virus derived from culture in Huh-7 cell line; HCVpc; hepatitis C virus der
Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes
Keywords: Antiviral; Genetic Barrier; Host Factor; Receptor; Treatment; CLDN; claudin; CMFDA; 5-chloromethylfluorescein di-acetate; CTRL; control; EL1; extracellular loop 1; HA-tag; hemaglutinin-tag; HCV; hepatitis C virus; HCVcc; cell culture-derived HCV; HCVpp; H
A synthon approach to spiro compounds
Keywords: Photochromism; Synthon; Spiro compounds; BINAP; 2,2â²-bis(diphenylphospospiro)-1,1â²-binaphthalene; Boc; t-butoxycarbonyl; CTAB; cetyltrimethylammonium bromide; DEAD; diethylazodicarboxylate; 4-DMAP; 4-(dimethylamino)pyridine; Fmoc; 9-fluorenylmethoxyca
Hydrocephalus after intraventricular hemorrhage in preterm and low-birth weight infants: analysis of associated risk factors for ventriculoperitoneal shunting
Keywords: CSF; cerebrospinal fluid; IVH; intraventricular hemorrhage; PHH; posthemorrhagic hydrocephalus; PT-LBWI; preterm and low-birth weight infant; V-P; ventriculoperitoneal; Intraventricular hemorrhage; Low birth weight; Newborn; Posthemorrhagic hydrocephalu