دانلود مقالات ISI درباره فسفاتیدیلینواستیل 3-کیناز + ترجمه فارسی

Prostaglandin E2 as a Regulator of Immunity to Pathogens

Keywords: فسفاتیدیلینواستیل 3-کیناز; AA; Arachidonic Acid; BMT; Bone marrow transplant; cAMP; Cyclic adenosine monophosphate; COX; Cyclooxygenase; EP; E-type prostanoid; EPAC; Exchange protein directly activated by cAMP; ERK; Extracellular signal-regulated kinases; GSK-3; Glycogen synthase k

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation

Keywords: فسفاتیدیلینواستیل 3-کیناز; DNMT1; DNA-methyltransferase 1; FOXO; Forkhead box O transcription factors; GST; glutathione S-transferase; HBP1; HMG-box protein 1; HEK; human embryonic kidney; HMG; high mobility group; HPLC; high performance liquid chromatography; KD; kinase dead; MS;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice

Keywords: فسفاتیدیلینواستیل 3-کیناز; Oncogene; Pancreatic Cancer; Transcriptional Regulator; Tumorigenesis; 2D; 2-dimensional; 3D; 3-dimensional; ATP; adenosine triphosphate; IPMN; intraductal papillary mucinous neoplasm; MCN; mucinous cystic neoplasm; PI3K; phosphatidylinositol 3-kinase; Pa

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Spinal SHP2 Contributes to Exaggerated Incisional Pain in Adult Rats Subjected to Neonatal and Adult Incisions via PI3K

Keywords: فسفاتیدیلینواستیل 3-کیناز; AMPA receptor; α-amino-3-hydroxy-5-methy-4-isoxazole propionate receptor; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; DRG; dorsal root ganglion; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol-bis(β-aminoethyl ethe

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2018 سفارش ترجمه

Chronic exposure of the RAW246.7 macrophage cell line to H2O2 leads to increased catalase expression

Keywords: فسفاتیدیلینواستیل 3-کیناز; ROS; reactive oxygen species; GSH; glutathione; SOD; superoxide dismutase; PTPs; protein tyrosine phosphatases; NEM; N-ethylmaleimide; DTNB; 5,5-dithio-bis-(2-nitrobenzoic acid); PMA; phorbol 12-myristate 13-acetate; ASK1; apoptosis signal-regulating kina

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

Computational design and experimental characterization of a novel β-common receptor inhibitory peptide

Keywords: فسفاتیدیلینواستیل 3-کیناز; EPO; erythropoietin; βCR; beta common receptor; IL; interleukin; GM-CSF; graulocyte macrophage colony stimulating factor; JAK; janus kinase; STAT; signal transducer and activator of transcription; MAPK; mitogen-activated protein kinase; PI3K; phosphatidy

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways

Keywords: فسفاتیدیلینواستیل 3-کیناز; Cardiac glycoside; Anti-Cancer; Helleborus thibetanus Franch.; Apoptosis; ERK and JNK pathways; PI3K-Akt-mTOR pathway; CGs; cardiac glycosides; FEN1; flap endonuclease 1; PARP; (poly (ADP-ribose) polymerase; MAPK; mitogen-activated protein kinase; ERK1/2;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C

Keywords: فسفاتیدیلینواستیل 3-کیناز; CS; Complement System; C7; Complement Component 7; MAC; Membrane Attack Complex; HCC; Hepatocellular Carcinoma; PCR; Polymerase Chain Reaction; OR; Odds Ratio; CI; Confidence Interval; HCV; Hepatitis C Virus; SNP; Single Nucleotide Polymorphism; RNA; Ribo

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Critical role of mammalian target of rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization

Keywords: فسفاتیدیلینواستیل 3-کیناز; Vaccine; Bet v 1; flagellin; rFlaA; fusion protein; birch pollen allergy; IL-10 dendritic cell; mammalian target of rapamycin; metabolism; alum; Aluminum hydroxide; APC; Antigen-presenting cell; B/A; Bet v 1/alum; DC; Dendritic cell; 2-DO; 2-Deoxyglucose;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Anti-tumor effect of AZD8055 against neuroblastoma cells in vitro and in vivo

Keywords: فسفاتیدیلینواستیل 3-کیناز; NB; Neuroblastoma; IGF; Insulin and insulin-like growth factors; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; p70S6K; p70 ribosomal protein S6 kinase; 4E-BP1; eukaryotic translat

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

The role of insulin signalling in the endocrine stress response in Drosophila melanogaster: A mini-review

Keywords: فسفاتیدیلینواستیل 3-کیناز; JH; juvenile hormone; JHE; JH-esterase; DA; dopamine; ALP; alkaline phosphatase; TH; tyrosine hydroxylase; OA; octopamine; TDC; tyrosine decarboxylase; 20E; 20-hydroxyecdysone; E20MO; ecdysone 20-monooxygenase; CA; corpus allatum; IIS; insulin/insulin-lik

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

HOXB4 knockdown enhances the cytotoxic effect of paclitaxel and cisplatin by downregulating ABC transporters in ovarian cancer cells

Keywords: فسفاتیدیلینواستیل 3-کیناز; ABCB1; ATP Binding Cassette Subfamily B Member 1; ABCC1; ATP Binding Cassette Subfamily C Member 1; ABCG2; ATP Binding Cassette Subfamily G Member 2; HOXB13; Homeobox B13; HOXB4; Homeobox B4; LDH; lactate dehydrogenase; PI3K; phosphatidylinositol 3-kinase

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Endocrine and physiological regulation of neutral fat storage in Drosophila

Keywords: فسفاتیدیلینواستیل 3-کیناز; Lipid metabolism; Drosophila; Obesity; Insulin; TOR; Ecdysone; AGPAT; acylglycerol-3-phosphate acyltransferase; AKH; adipokinetic hormone; BMM; Brummer; CC; corpora cardiac; DAG; diacylglycerol; Dilp; Drosophila insulin-like peptide; DGAT; diacylglycerol

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients

Keywords: فسفاتیدیلینواستیل 3-کیناز; HCV; Hepatitis C Virus; CHC; Chronic Hepatitis C; HCC; Hepatocellular Carcinoma; IR; Insulin Resistance; T2D; Type 2 Diabetes; MENA; Middle-Esat and North Africa; IRS-1/2; Insulin receptor substrate-1/2; PI3K; phosphatidylinositol 3-kinase; SOCS-3; Suppre

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Class I PI3K inhibitor ZSTK474 attenuates experimental autoimmune neuritis by decreasing the frequency of Th1/Th17 cells and reducing the production of proinflammatory cytokines

Keywords: فسفاتیدیلینواستیل 3-کیناز; AUC; area under the curve; CMAP; compound muscle action potential; DAPI; 4′,6-diamidino-2- phenylindole; dpi; days post-inoculation; EAN; experimental autoimmune neuritis; ELISA; enzyme-linked immunosorbent assay; EMG; electromyography; GAPDH; glycerald

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Oocyte-G1 promotes male germ cell apoptosis through activation of Caspase-3

Keywords: فسفاتیدیلینواستیل 3-کیناز; Kif; Kinesin superfamily; TUNEL; Transferase-mediated deoxyuridine triphosphate-biotin nick end labeling; Pro-caspase-3; Prototype of caspase-3; PCNA; Proliferating Cell Nuclear Antigen; STAT3; Signal transducer and activator of transcription 3; TGF-β; T

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

BCAP promotes osteoclast differentiation through regulation of the p38-dependent CREB signaling pathway

Keywords: فسفاتیدیلینواستیل 3-کیناز; BCAP; B-cell adaptor for PI3K; PI3K; phosphatidylinositol 3-Kinase; BMM; bone marrow-derived monocyte/macrophage lineage cell; NFATc1; nuclear factor of activated T-cells c1; TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Kα H1047R mutant inhibitors

Keywords: فسفاتیدیلینواستیل 3-کیناز; Anticancer drug; Phosphatidylinositol 3-kinase; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

F2-isoprostanes affect macrophage migration and CSF-1 signalling

Keywords: فسفاتیدیلینواستیل 3-کیناز; Akt; Protein Kinase B; BMM; Bone Marrow derived Macrophages; BSA; Bovine Serum Albumin; Chol-IsoP; Cholesterol-Isoprostane; CSF-1; Colony Stimulating Factor-1; CSF-1R; Colony Stimulating Factor-1 Receptor; DAPI 4′; 6-Diamidino-2-phenylindole; DMSO; Dime

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells

Keywords: فسفاتیدیلینواستیل 3-کیناز; HCC; hepatocellular carcinoma; 5-FU; 5-fluorouracil; MEL; melittin; P-gp; P-glycoprotein; AMPs; antimicrobial peptides; LDH; lactate dehydrogenase; SEM; scanning electron microscope; BMSCs; bone mesenchymal stem cells; IGF-I; insulin­like growth factor I

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Concomitance of EGFR mutations and ALK rearrangement in patients with Lung Cancer

Keywords: فسفاتیدیلینواستیل 3-کیناز; ALK; Anaplastic lymphoma kinase; EGFR; Epithelial growth factor receptor; EML4; Echinoderm Microtubule Associated Protein Like 4; K-Ras; Kirsten rat sarcoma viral; MAPK; Mitogen-activated protein kinases; NSCLCs; Non-small cell lung cancers; PI3K; Phospha

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway

Keywords: فسفاتیدیلینواستیل 3-کیناز; ACC; acetyl-CoA carboxylase; Ac-Lys; acetylated lysine; AMPK; AMP-activated protein kinase; BMMCs; bone marrow-derived mast cells; HSA; human serum albumin; IKK; IκB kinase; IL-6; interleukin-6; JNK; c-Jun N-terminal kinase; LAT; linker for activation of

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise

Keywords: فسفاتیدیلینواستیل 3-کیناز; ANOVA; analysis of variance; A1R; adenosine A1 receptor; CAT; Catalase; DEXA; dual energy X-ray absorptiometry; DW; distilled water; GSH; Glutathione; HE; haematoxylin and eosin; HNE; hydroxynonenal; iNOS; inducible nitric oxide synthase; LDH; lactate deh

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells

Keywords: فسفاتیدیلینواستیل 3-کیناز; AmA; antimycin A; AMPK; adenosine monophosphate-activated protein kinase; CoQ; coenzyme Q10; DCF; 2′,7′-dichlorofluorescin; DCFH-DA; 2′,7′-dichlorofluorescin diacetate; ddPCR; droplet digital PCR; ETS; electron transfer system; FBS; fetal bovine s

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Ca2+ signaling and Src-kinases-controlled cellular functions

Keywords: فسفاتیدیلینواستیل 3-کیناز; Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

Keywords: فسفاتیدیلینواستیل 3-کیناز; ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

Keywords: فسفاتیدیلینواستیل 3-کیناز; Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Emerging paradigms in the treatment of liver metastases in colorectal cancer

Keywords: فسفاتیدیلینواستیل 3-کیناز; CRC; colorectal cancer; mCRC; metastatic colorectal cancer; CLM; colorectal liver metastases; SR; surgical resection; PVE; portal vein embolism; RFA; radiofrequency ablation; APC; adenomatous polyposis coli; LOH; loss of heterozygosity; EGFR; epidermal gr

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Keywords: فسفاتیدیلینواستیل 3-کیناز; ABL; Abelson murine leukemia viral oncogene homolog 1; ALIS; aggresome-like induced structure; ALL; acute lymphoblastic leukemia; BCR; breakpoint cluster region; CML; chronic myeloid leukemia; DCFH-DA; 2′, 7′-dichlorodihydrofluorescein diacetate; DCPI

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway

Keywords: فسفاتیدیلینواستیل 3-کیناز; apoA-I; apolipoprotein A-I; ANGPTL4; angiopoietin like 4; CETP; cholesterol ester transfer protein; CHX; cycloheximide; CVD; cardiovascular disease; EBM; endothelial cell basal medium; eNOS; endothelial NO synthase; ERK; extracellular signal-regulated kin

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway

Keywords: فسفاتیدیلینواستیل 3-کیناز; HFD; high fat-diet; STZ; streptozotocin; IRS-1; insulin receptor substrate-1; PI3K; phosphatidylinositol 3-kinase; PEPCK; phosphoenolpyruvate carboxykinase; G6pase; glucose 6-phosphatase; FOXO1; forkhead box O1; GSK3β; glycogen synthase kinase-3β; GS; g

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium

Keywords: فسفاتیدیلینواستیل 3-کیناز; BBS8; Bardet-Biedl syndrome 8; bFGF; basic fibroblast growth factor; BMP; bone morphogenetic protein; BMSCs; bone marrow-derived hematopoietic stem cells; ECM; extracellular matrix; EGF; epidermal growth factor; EMT; epithelial-to-mesenchymal transition;

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2018 سفارش ترجمه

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

Keywords: فسفاتیدیلینواستیل 3-کیناز; Siglec-8; endocytosis; eosinophil; mast cell; allergic diseases; chronic eosinophilic leukemia; systemic mastocytosis; immunotoxin; targeting; BIM; Bisindolylmaleimide I; DAPI; 4′-6-Diamidino-2-phenylindole; ITIM; Immunoreceptor tyrosine-based inhibitor

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

Keywords: فسفاتیدیلینواستیل 3-کیناز; ASK1; apoptosis signal regulating kinase 1; Cul3; cullin 3; DEF; dimethylfumarate; DEM; diethylmaleate; 15d-PGJ2; 15-deoxy-Δ12,14-prostaglandin J2; FBS; fetal bovine serum; 5-HI; 5-hydroxyoxindole derivative; HO-1; heme oxygenase-1; iNOS; inducible NO sy

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK

Keywords: فسفاتیدیلینواستیل 3-کیناز; 2-NBDG; 2-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]amino)-2-deoxyglucose; AICAR; 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt Substrate of 160 kDa; ATF4; Activating Transcription Factor 4; AUC; area un

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2018 سفارش ترجمه

Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers

Keywords: فسفاتیدیلینواستیل 3-کیناز; ARTN; artemin; AS; activation segment; CD; cadherin-like domain; CDK; cyclin-dependent protein kinase; CL; catalytic loop; CS or C-spine; catalytic spine; CTT; carboxyterminal tail; EGFR; epidermal growth factor receptor; FGFR; fibroblast growth factor re

دانلود رایگان متن کامل مقاله ISI 70 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy in ischemic stroke

Keywords: فسفاتیدیلینواستیل 3-کیناز; 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5′-triphosphate; BBB; blood-brain ba

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2018 سفارش ترجمه

Protein kinase C-eta regulates Mcl-1 level via ERK1

Keywords: فسفاتیدیلینواستیل 3-کیناز; DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; GSK3; glycogen synthase kinase-3; MAPK; mitogen-activated protein kinase; Mcl-1; myeloid cell leukemia-1; Mule; Mcl-1 ubiquitin ligase; PI3K; phosphatidylinositol 3-kinase; PKC; protein kina

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet

Keywords: فسفاتیدیلینواستیل 3-کیناز; Adipocyte number; Adipogenesis; Glucose tolerance; Phytol; PI3K/Akt; Mice; Akt; protein kinase B; aP2; adipocyte protein 2; AS160; Akt substrate of 160 kDa; AUC; area under the curve; C/EBPα; CCAAT-enhancer-binding proteins; FoxO1; Forkhead box protein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating α7nAChR/PI3K/Trx-1 and suppressing ER stress

Keywords: فسفاتیدیلینواستیل 3-کیناز; PD; Parkinson's disease; MPP+1; methyl-4-phenylpyridinium ion; Trx-1; thioredoxin-1; ER; endoplasmic reticulum; GRP78/Bip; glucose-regulated protein 78; CHOP; C/EBP homologous protein; TH; tyrosine hydroxylase; PI3K; phosphatidylinositol 3-kinase; DA; d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Phosphatidylinositol 3-kinase inhibition induces vasodilator effect of sevoflurane via reduction of Rho kinase activity

Keywords: فسفاتیدیلینواستیل 3-کیناز; Anesthetics; Phosphatidylinositol 3-kinase; Rho kinase; Sevoflurane;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways

Keywords: فسفاتیدیلینواستیل 3-کیناز; Icariin; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Phosphatidylinositol 3-kinase; Mitogen-activated protein kinase kinase; Dopamine; Parkinson's disease; DA; dopamine; IGF-1R; insulin-like growth factor-1 receptor; IRS-1; insulin receptor substrate-1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination

Keywords: فسفاتیدیلینواستیل 3-کیناز; Insulin-like growth factor (IGF); Insulin receptor substrate (IRS)-2; Ubiquitin-specific protease 15 (USP15); Nedd4; Ubiquitination; IGF; insulin-like growth factor; IRS; insulin receptor substrate; PI3K; phosphatidylinositol 3-kinase; USP; ubiquitin-spec

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Neonatal Fc receptor FcRn is involved in intracellular transport of the Fc fusion protein aflibercept and its transition through retinal endothelial cells

Keywords: فسفاتیدیلینواستیل 3-کیناز; Retinal endothelial cells; Aflibercept; Fc fusion protein; IgG; Neonatal Fc receptor; Internalization; Transport; Transcytosis; DMSO; dimethyl sulfoxide; EEA1; early endosome antigen 1; Fc; fragment crystalisable; FcRn; neonatal Fc receptor; FBS; fetal bo

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro

Keywords: فسفاتیدیلینواستیل 3-کیناز; PM2.5; Fine particulate matter of < 2.5 µm in aerodynamic diameter; COFs; Cooking oil fumes; LBW; Low birth weight; ROS; Reactive oxygen species; PI3K; Phosphatidylinositol 3-kinase; mTOR; Mechanistic target of rapamycin; HUVECs; Human umbilical vein en

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleRas inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway

Keywords: فسفاتیدیلینواستیل 3-کیناز; Metastasis; Ras; Ras inhibitors; LOX; PI3K; HIF-1α; CRC; colorectal cancer; LOX; lysyl oxidase; PI3K; phosphatidylinositol 3-kinase; HIF; hypoxia-inducible factor; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; ECM; extracellula

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia

Keywords: فسفاتیدیلینواستیل 3-کیناز; Mnk inhibitor; FLT3 inhibitor; Dual inhibitor; AML; Drug discovery; Anti-leukaemic agent; AML; acute myeloid leukaemia; CDK; cyclin-dependent kinase; eIF; eukaryotic initiation factor; Erk; extracellular signal-regulated kinase; FLT3; Fms-like tyrosine ki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II

Keywords: فسفاتیدیلینواستیل 3-کیناز; EB; elementary body; RB; reticulate bodies; PI3K; phosphatidylinositol 3-kinase; HKII; hexokinase II; VDAC; voltage-dependent anion channel; CTL2; Chlamydia trachomatis L2; p.i.; post-infection; TNF-α; tumor necrosis factor-α; PARP; poly-(ADP-ribose) po

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line

Keywords: فسفاتیدیلینواستیل 3-کیناز; AP-1; activator protein-1; BRB; blood retinal barrier; DR; diabetic retinopathy; MMP; matrix metalloproteinase; NF-κB; nuclear factor-kappa B; PI3K; phosphatidylinositol 3-kinase; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; PMF; polymeth

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Original ResearchA phase IB dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin (with or without bevacizumab) in patients wi

Keywords: فسفاتیدیلینواستیل 3-کیناز; Phosphatidylinositol 3-kinase; Non-small cell lung; Bevacizumab; Paclitaxel; Carboplatin; Cisplatin; Pemetrexed; Metastatic NSCLC; Front-line NSCLC; First-line NSCLC;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه