کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8450922 | 1547690 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-tumor effect of AZD8055 against neuroblastoma cells in vitro and in vivo
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
mTOR complex 2mTORC2CDK4/6mTORC14E-BP1AZD8055PARP3-MAp70S6Ki.p.mTORIC50mTOR kinaseFBSIGFPI3K3-methyladenine - 3-متیل آدنینmTOR complex 1 - mTOR پیچیده 1p70 ribosomal protein S6 kinase - P70 پروتئین ریبوزومی S6 کینازAutophagy - اتوفاژیApoptosis - خزان یاختهایfetal bovine serum - سرم جنین گاوPhosphatidylinositol 3-kinase - فسفاتیدیلینواستیل 3-کینازNeuroblastoma - نوروبلاستوماhalf maximal inhibitory concentration - نیمه حداکثر غلظت مهاریmammalian target of rapamycin - هدف پستانداران رپامایسینpoly ADP-ribose polymerase - پلی ADA-ribose پلیمراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Neuroblastoma (NB) is one of the most common solid tumors in children. High-risk NB remains lethal in about 50% of patients despite comprehensive and intensive treatments. Activation of PI3K/Akt/mTOR signaling pathway correlates with oncogenesis, poor prognosis and chemotherapy resistance in NB. Due to its central role in growth and metabolism, mTOR seems to be an important factor in NB, making it a possible target for NB. In this study, we investigated the effect of AZD8055, a potent dual mTORC1-mTORC2 inhibitor, in NB cell lines. Our data showed that mTOR signaling was extensively activated in NB cells. The activity of mTOR and downstream molecules were down-regulated in AZD8055-treated NB cells. Significantly, AZD8055 effectively inhibited cell growth and induced cell cycle arrest, autophagy and apoptosis in NB cells. Moreover, AZD8055 significantly reduced tumor growth in mice xenograft model without apparent toxicity. Taken together, our results highlight the potential of mTOR as a promising target for NB treatment. Therefore, AZD8055 may be further investigated for treatment in clinical trials for high risk NB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 365, Issue 2, 15 April 2018, Pages 177-184
Journal: Experimental Cell Research - Volume 365, Issue 2, 15 April 2018, Pages 177-184
نویسندگان
Dong-Qing Xu, Hidemi Toyoda, Xiao-Jun Yuan, Lei Qi, Vipin Shankar Chelakkot, Mari Morimoto, Ryo Hanaki, Kentarou Kihira, Hiroki Hori, Yoshihiro Komada, Masahiro Hirayama,