دانلود مقالات ISI درباره Mtor Complex 2 + ترجمه فارسی

سیگنالینگ مضر در سرطان

Contextual signaling in cancer

Keywords: AKT; protein kinase B; ATF4; activating transcription factor 4; cAMP; cyclic adenosine monophosphate; CCL5; (C-C motif) ligand 5; CNS; central nervous system; 4EBP1; 4E (elF4E) binding protein; ECM; extracellular matrix; ERK; p44/p42 extracellular signal-

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Anti-tumor effect of AZD8055 against neuroblastoma cells in vitro and in vivo

Keywords: NB; Neuroblastoma; IGF; Insulin and insulin-like growth factors; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; p70S6K; p70 ribosomal protein S6 kinase; 4E-BP1; eukaryotic translat

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis

Keywords: ACSS2; acyl-coenzyme A synthetase short-chain family member 2; ATPB; β-F1-ATPase; BSM; bronchial smooth muscle; CPT1A; carnitine palmitoyltransferase 1A; ER; estrogen receptor; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GLS; glutaminase; GLUT1; glu

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Keywords: AMPK; 5′ adenosine monophosphate-activated protein kinase; AR; adrenoceptor; CaMKK; calmodulin-dependent protein kinase kinase; CHO; Chinese hamster ovary; Comp C; compound C; DAG; diacylglycerol; IP3; inositol 1,4,5-trisphosphate; mTOR; mechanistic tar

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes

Keywords: Cytomegalovirus; Monocytes; Small-molecule inhibitor; HCMV; human cytomegalovirus; h; hour; EGF; epidermal growth factor; EGFR; EGF receptor; αvβ3; alpha v beta 3 integrin; gB; glycoprotein B; gH; glycoprotein H; PI3K; phosphoinositide 3-kinase; PTEN; p

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress

Keywords: βRicKO; β-cell-specific knockout of Rictor; GIIS; glucose-induced insulin secretion; HFD; high-fat diet; NCD; normal chow diet; mTOR; mechanistic target of rapamycin; mTORC2; mTOR complex 2; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; R

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease

Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation

Keywords: Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2017 سفارش ترجمه

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

Keywords: 4E-BP1; 4E binding protein; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATP; adenosine triphosphate; DEPTOR; DEP domain containing mTOR-interacting protein; CI; complexes I; CII; complex II; CIII; complex III; CIV; complex

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

Uroguanylin modulates (Na+ + K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways

Keywords: UGN; uroguanylin; PT; proximal tubule; GFR; glomerular flow rate; NHE3; Na+/H+ exchanger isoform 3; PKA; protein kinase A; PKG; protein kinase G; Gi; inhibitory G protein; PKB; protein kinase B; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

Keywords: mTOR; mammalian target of rapamycin; UVB; ultraviolet-B; NMSC; non-melanoma skin cancer; mTORC1; mTOR complex 1; mTOC2; mTOR complex 2; AKT/PKB; protein kinase B; SCC; squamous cell carcinoma; ERK; extracellular-signal-regulated kinases; MEK; mitogen-acti

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets

Keywords: (PKB); Protein kinase B; (T2D); type 2 diabetes; (FFA); free fatty acids; (IRS); insulin receptor substrate; (PI3K); phosphoinositide 3-kinase; (mTORC2); mTOR complex 2; (KO); knockout; (INS); rat insulinoma cells; (GOF); gain of function; (GSIS); glucose

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Protection of pancreatic β-cells against glucotoxicity by short-term treatment with GLP-1

Keywords: Glucagon-like peptide-1; Glucotoxiciy; FoxO-1; mTOR complex 2; Pancreatic β-cell; Type 2 diabetesATF, activating transcription factor; CHOP, C/EBP homologous protein; Epac, exchange protein activated by cAMP; FoxO-1, forkhead transcription factors of the

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy

Keywords: SPC; sphingosylphosphorylcholine; I/R; ischemia/reperfusion; MTOR; mammalian target of rapamycin; MTORC1; mTOR complex 1; MTORC2; mTOR complex 2; MI; myocardial infarction; PI3K; phosphatidylinositol 3-kinase; TSC2; tuberous sclerosis complex 2; HUVECs; h

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches

Keywords: PI3K; phosphatidylinositide 3-kinase; PIP2; phosphatidylinositol-4,5-bisphosphate; PIP3; phosphatidylinositol-3,4,5-trisphosphate; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; ASA; accessible surface area; ΔASA; lo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions

Keywords: Raptor; regulatory associated protein of mTOR; Rictor; rapamycin-insensitive companion of mTOR; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; m-TORC2; mTOR complex 2; Sp1; specific protein 1; MTH; mithramycin; RAPA; rapamycin; ChIP; chromat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; ATP; adenosine triphosphate; Bci3; Bax cannel inhibitor 3; cAMP; cyclic adenosine monophosphate; CMA; chaperone-mediated autophagy; DLB; dement

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2015 سفارش ترجمه

MYC and metabolism on the path to cancer

Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells

Keywords: MTT; 3-[4,5-Dimethylthylthiazol-2-yl]-2,5 diphenyltetrazolium bromide; FACS; fluorescence-activated cell sorting; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; 4E-BP1; 4E-binding protein; OD; optical density; IP; imm

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components

Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014

Keywords: 3-MA; 3-methyaldenine; 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; mTOR; mammalian target or rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; S6K; p70-S6 Kinase 1; LC3B; light chain 3B; Colorectal cancer; AZD-2014; mTOR complexes;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibitory effect of 14,15-EET on endothelial senescence through activation of mTOR complex 2/Akt signaling pathways

Keywords: EETs; epoxyeicosatrienoic acids; eNOS; endothelial nitric oxide synthase; mTOR; mammalian target of rapamycin; mTORC2; mTOR complex 2; RMAECs; rat mesenteric arterial endothelial cells; rTERT; rat telomerase reverse transcriptase; SA-β-gal; senescence-as

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production

Keywords: ABCG1; ATP binding cassette transporter G1; BP-C; Bodipy-cholesterol; BP-CE; Bodipy-cholesteryl oleate; CETP; cholesteryl ester transfer protein; DAF-2 DA; 4,5-diaminofluorescein diacetate; DiI; 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

PKI-587 and Sorafenib Targeting PI3K/AKT/mTOR and Ras/Raf/MAPK Pathways Synergistically Inhibit HCC Cell Proliferation

Keywords: epidermal growth factor; sorafenib; PKI-587; PI-103; rapamycin; mTOR complex 1; mTOR complex 2; negative feedback loop

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

Keywords: 4E-BP1; 4E binding protein 1; 5′UTR; 5′ untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5′-AMP-activated protein kinase; AMPK α1−/−; AMPK α1 subunit knockout; AMPKα1−/−α2−/−; A

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Energy metabolism in adult neural stem cell fate

Keywords: ACC; adenylate cyclase complex; AICAR; aminoimidazole carboxamide ribonucleotide; AMPK; AMP-activated protein kinase; Aspm; abnormal spindle-like microcephaly-associated; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2011 سفارش ترجمه