کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480465 1551382 2015 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation
چکیده انگلیسی
Neuronal homeostasis depends on the proper functioning of quality control systems like autophagy. This mechanism is responsible of the clearance of misfolded proteins, aggregates and the turnover of organelles within the neuron. Autophagic dysfunction has been described in many neurodegenerative diseases. It can occur at several steps of the autophagic machinery and can contribute to the formation of intracellular aggregates and ultimately to neuronal death. Accordingly restoring autophagy activity in affected neurons can be an attractive therapeutic approach to fight neurodegeneration. In this review we summarize the present encouraging strategies that have been achieved with pharmacological and genetic treatments aimed to induce neuronal autophagy in experimental models of neurodegenerative diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 40, April 2015, Pages 115-126
نویسندگان
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