Keywords: فسفودی استراز 10A; Schizophrenia; Systems pharmacology; Drug treatment; PANSS Total; Combination therapy; Information bandwidth; CNS; Central Nervous Systems; DA; Dopamine; GPCR; G-Protein coupled receptor; GPe; Globus Pallidus Externa; GPi; Globus Pallidus interna; MSN; Me
مقالات ISI فسفودی استراز 10A (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: فسفودی استراز 10A; α-MSH; α-melanocyte-stimulating hormone; BAIBA; β-aminoisobutyric acid; ATGL; adipose triglyceride lipase; AR-beta3; adrenergic receptor beta 3; BMP; bone morphogenetic protein; BAT; brown adipose tissue; CPT1; carnitine palmitoyltransferase 1; CD36; c
Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening
Keywords: فسفودی استراز 10A; Phosphodiesterase 10A; Schizophrenia; Antipsychotic drugs; Ligand and structure-based pharmacophore; Virtual screening; Molecular docking; Structure-Activity-Relationship;
Chiral resolution of serial potent and selective Ï1 ligands and biological evaluation of (â)-[18F]TZ3108 in rodent and the nonhuman primate brain
Keywords: فسفودی استراز 10A; calcd; calculated; CH2Cl2; dichloromethane; CNS; central nervous system; DMSO; dimethyl sulfoxide; [3H]DTG; [3H]ditolylguanidine; DTTA; di-p-toluoyl tartaric acid; EBP; emopamil binding protein; ee; enantiomeric excess; EOB; end of bombardment; EtOH; etha
The phosphodiesterase 10A selective inhibitor, TAK-063, induces c-Fos expression in both direct and indirect pathway medium spiny neurons and sub-regions of the medial prefrontal cortex in rats
Keywords: فسفودی استراز 10A; ACC; anterior cingulate cortex; AI; anterior insular cortex; BOLD; blood oxygenation level dependent; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; dlPFC; dorsolateral prefrontal cortex; dmCpu; dorsomedial caudate-putamen; DP
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Keywords: فسفودی استراز 10A; Schizophrenia; Antipsychotic activity; Cognitive improvement; Phosphodiesterase 10A; Fragment-based drug discovery; Pyrazolopyrimidine; Rational design; Positron emission tomography
Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
Keywords: فسفودی استراز 10A; Phosphodiesterase 10A; PDE10A; Inhibitors; Schizophrenia; SBDD;
Discovery of [11C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors
Keywords: فسفودی استراز 10A; PDE10A; Positron emission tomography; PET tracer; Phosphodiesterase 10A; Imaging; Schizophrenia; Huntington's disease;
Pharmacological evaluation of a novel phosphodiesterase 10A inhibitor in models of antipsychotic activity and cognition
Keywords: فسفودی استراز 10A; Phosphodiesterase 10A; EEG; Striatum; Microdialysis;
A comparative study of binding affinities for 6,7-dimethoxy-4-pyrrolidylquinazolines as phosphodiesterase 10A inhibitors using the linear interaction energy method
Keywords: فسفودی استراز 10A; Phosphodiesterase 10A; Schizophrenia; Pyrrolidylquinazoline; Binding affinity; Linear interaction energy; Virtual screening and applicability domain
Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors
Keywords: فسفودی استراز 10A; Benzimidazole analogues; Cinnoline analogues; Phosphodiesterase 10A; PET;
Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice
Keywords: فسفودی استراز 10A; Type 1 cannabinoid receptor; Phosphodiesterase 10A; Huntington disease; Small-animal PET; R6/2 mice;
Novel triazines as potent and selective phosphodiesterase 10A inhibitors
Keywords: فسفودی استراز 10A; PDE10A; phosphodiesterase 10A; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanine monophosphate; MSN; medium spiny neuron; MK-801; dizocilpine maleate; MED; minimal effective dose; PDE; cyclic nucleotide phosphodiesterase; LMA; locomotor activity;
The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices
Keywords: فسفودی استراز 10A; Striatum; PDE10A; ERK; Dopamine; Estrogen; Gender; cAMP; 3â²,5â²-cyclic adenosine monophosphate; cGMP; Guanosine 3â²,5â²-cyclic mononucleotide; MSNs; medium spiny neurons; PDE10A; phosphodiesterase 10A; p-ERK; phosphorylated extracellular-signal-regul
Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain
Keywords: فسفودی استراز 10A; AMP; adenosine monophosphate; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; cGMP; cyclic guanosine monophosphate; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; GMP; guanosine monophosphate; HD; Huntington disease; LDA; lithium
PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: A key step in parkinsonism physiopathology
Keywords: فسفودی استراز 10A; cAMP; adenosine 3â², 5â²-cyclic monophosphate; cGMP; guanosine 3â²,5â²-cyclic monophosphate; PDE; 3â²,5â²-cyclic nucleotide phosphodiesterases; MSN; medium spiny neurons; PDE10A; phosphodiesterase 10A; PDE1B; phosphodiesterase 1B; 6-OHDA; 6-hydroxyd
Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation
Keywords: فسفودی استراز 10A; PDE10A; PET; Radiotracer; CNS; Phosphodiesterase 10A; C-11; Papaverine
Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis
Keywords: فسفودی استراز 10A; Phosphodiesterase; Phosphodiesterase 10A; Conditioned avoidance response; Basal ganglia; Schizophrenia