Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 24, Issue 16, 15 August 2016, Pages 3447-3455

Masato Yoshikawa, Takenori Hitaka, Tomoaki Hasui, Makoto Fushimi, Jun Kunitomo, Hironori Kokubo, Hideyuki Oki, Kosuke Nakashima, Takahiko Taniguchi,