PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: A key step in parkinsonism physiopathology

► Dopamine loss up- or down-regulates PDE10A respectively in n. accumbens and striatum. ► cAMP is up-regulated in striatum but down-regulated in n. accumbens by dopamine loss. ► cGMP is down-regulated both in the striatum and n. accumbens by dopamine loss. ► PDE10A up- and down-regulation parallels cAMP but not cGMP altered by dopamine loss.