Keywords: مدل فیزیولوژیکی; clinical pharmacokinetics; distribution; hepatic clearance; in vitro-in vivo correlations (IVIVC); metabolic clearance; oral absorption; physiological model; preclinical pharmacokinetics; protein binding; simulations;
مقالات ISI مدل فیزیولوژیکی (ترجمه نشده)
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Keywords: مدل فیزیولوژیکی; Mathematical model; Physiological model; Control-theoretic model; Plasma volume; Blood volume; In-silico evaluation; Pre-clinical evaluation; Physiological closed-loop control; Circulatory resuscitation;
Keywords: مدل فیزیولوژیکی; pharmacokinetics; physiological model; inhibition; bioavailability; DCA; dichloroacetic acid; GSTZ1-1; glutathione transferase zeta 1; GI; gastrointestinal; IIV; inter-individual variability; pcVPC; prediction-corrected visual predictive check;
Keywords: مدل فیزیولوژیکی; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: مدل فیزیولوژیکی; skin; injectables; injectors; physiological model; biocompatibility; monoclonal antibody; subcutaneous; parenteral; device; pain;
Keywords: مدل فیزیولوژیکی; Epilepsy; Effective connectivity; Dynamic causal modeling; Physiological model; Power spectral density; EM algorithm
Keywords: مدل فیزیولوژیکی; ADME; bioavailability; biopharmaceutics classification system (BCS); clinical pharmacokinetics; clearance; formulation; oral absorption; physiological model; preclinical pharmacokinetics; solubility
Keywords: مدل فیزیولوژیکی; physiological model; absorption; bioequivalence; bioavailability; clinical trial simulation; modified release
Keywords: مدل فیزیولوژیکی; bioavailability; compartment model; distribution; drug interactions; fluvoxamine; hepatic blood level; hepatic clearance; pharmacokinetics; physiological model; simulation;
Keywords: مدل فیزیولوژیکی; degradation product; pharmacokinetics; physiological model; population pharmacokinetics; Monte Carlo; stability
Keywords: مدل فیزیولوژیکی; Type 1 diabetes mellitus; Blood glucose prediction; Therapy parameters; Physiological model; Blood glucose control;
Keywords: مدل فیزیولوژیکی; omega-3 fatty acids; antidepressants; fluoxetine; forced swimming test; depression; drug effects; drug-like properties; pharmacodynamic; preclinical pharmacokinetic; physiological model;
Keywords: مدل فیزیولوژیکی; mouse models; immunogenicity risk; protein aggregation; tolerance; ADA; stability; immunology; oxidation; physiological model; particle size;
Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification
Keywords: مدل فیزیولوژیکی; in silico modeling; disposition; pharmacokinetic/pharmacodynamic models; pharmacokinetics; physiological model;
Exploration of PBPK Model-Calculation of Drug Time Course in Tissue Using IV Bolus Drug Plasma Concentration-Time Profile and the Physiological Parameters of the Organ
Keywords: مدل فیزیولوژیکی; tissue partitioning; partition coefficient; physiological model; well-stirred model; distribution; linear pharmacokinetics;
Utilizing Physiologically Based Pharmacokinetic Modeling to Inform Formulation and Clinical Development for a Compound with pH-Dependent Solubility
Keywords: مدل فیزیولوژیکی; absorption; disposition; pharmacokinetics; ADME; physiological model;
Application and Validation of an Advanced Gastrointestinal In Vitro Model for the Evaluation of Drug Product Performance in Pharmaceutical Development
Keywords: مدل فیزیولوژیکی; dissolution; solubility; bioavailability; in vitro/in vivo correlations (IVIVC); intestinal absorption; physiological model; TNO TIMâ1; formulation; poorly soluble drugs;
A Mechanistic Physiologically Based Pharmacokinetic-Enzyme Turnover Model Involving both Intestine and Liver to Predict CYP3A Induction-Mediated Drug-Drug Interactions
Keywords: مدل فیزیولوژیکی; cytochrome P450; CYP3A; physiological model; enzyme turnover model; induction; drug interaction; dynamic simulation; pharmacokinetics; in vitro-in vivo prediction;
Issues, challenges, and opportunities in model-based drug development for monoclonal antibodies
Keywords: مدل فیزیولوژیکی; pharmacokinetics/pharmacodynamics; computational biology; physiological model; pharmacokinetics; pharmacodynamics; allometry; nonlinear pharmacokinetics; antibody; PK/PD
Prediction of Drug Terminal Half-Life and Terminal Volume of Distribution After Intravenous Dosing Based on Drug Clearance, Steady-State Volume of Distribution, and Physiological Parameters of the Body
Keywords: مدل فیزیولوژیکی; terminal half-life and volume of distribution; steady-state volume of distribution; clearance; residence time; blood-plasma ratio; physiological model; blood flow; elimination; prediction of human pharmacokinetics;
Development of a Hybrid Physiologically Based Pharmacokinetic Model with DrugâSpecific Scaling Factors in Rat to Improve Prediction of Human Pharmacokinetics
Keywords: مدل فیزیولوژیکی; ADME; in vitroâin vivo extrapolation (IVIVE); metabolic clearance; modeling and simulation; PBPK modeling; pharmacokinetics; physiological model; prediction of human pharmacokinetics; simulations; translational research;
Modeling the environmental response of leaf net photosynthesis in Pinus pinea L. natural regeneration
Keywords: مدل فیزیولوژیکی; Non-rectangular hyperbola model; Net assimilation rate; Physiological model; Leaf respiration; Ecological niche
Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics
Keywords: مدل فیزیولوژیکی; total body clearance; hepatic clearance; physiological model; lung metabolism; distribution; elimination; venous blood; arterial blood;
Microdosing: A Critical Assessment of Human Data
Keywords: مدل فیزیولوژیکی; pharmacokinetics; bioavailability; biopharmaceutical drug disposition classification system (BDDCS); oral absorption; PET; physiological model;
Comparative Pharmacokinetics Studies of Immediate- and Modified-Release Formulations of Glipizide in Pigs and Dogs
Keywords: مدل فیزیولوژیکی; absorption; bioavailability; controlled release; pharmacokinetics/pharmacodynamics model; physiological model; dissolution; in vitro/in vivo correlation (IVIVC);
Determination of Hepatic Clearance with the Account of Drug-Protein Binding Kinetics
Keywords: مدل فیزیولوژیکی; protein binding kinetics; hepatic clearance; wellâstirred model; parallel tube model; dissociation; drug ionization; extracellular and intracellular water distribution; physiological model; pharmacokinetics;
Prediction of Concentration-Time Profile and its Inter-Individual Variability following the Dermal Drug Absorption
Keywords: مدل فیزیولوژیکی; transdermal drug delivery; mathematical model; ADME (absorption; distribution; metabolism; excretion); in vitro-in vivo extrapolation (IVIVE); physiological model; physiologically based pharmacokinetic (PBPK) models; inter-individual variability; Simcyp
Physiologically Based Pharmacokinetic Tissue Compartment Model Selection in Drug Development and Risk Assessment
Keywords: مدل فیزیولوژیکی; pharmacokinetics; physiological model; well stirred model; tissue partition; in silico modeling; physicochemical; singular perturbation; asymptotic matching; flow-limited; compartmental modeling;
Tissue lipids and drug distribution: Dog versus rat
Keywords: مدل فیزیولوژیکی; dog; tissue constituents; in silico modeling; pharmacokinetics; phospholipids; tissue partition; physiological model; physicochemical properties; partition coefficients; PBPK modeling;
Dermal Clearance Model for Epidermal Bioavailability Calculations
Keywords: مدل فیزیولوژیکی; absorption; clearance; dermis; distribution; lymphatic transport; mathematical model; physiological model; protein binding; skin; transdermal;
Application of pharmacokinetics-pharmacodynamics/clinical response modeling and simulation for biologics drug development
Keywords: مدل فیزیولوژیکی; ADME; pharmacokinetics; pharmacodynamics; pharmacokinetic/pharmacodynamic models; physiological model;
Drug Delivery Trends in Clinical Trials and Translational Medicine: Evaluation of Pharmacokinetic Properties in Special Populations
Keywords: مدل فیزیولوژیکی; pharmacokinetics; pharmacokinetics/pharmacodynamics; physiological model; population pharmacokinetics/pharmacodynamics; pediatric; elderly; inclusions; ADME; clinical pharmacokinetics
Customized In Silico Population Mimics Actual Population in Docetaxel Population Pharmacokinetic Analysis
Keywords: مدل فیزیولوژیکی; population pharmacokinetics; pharmacokinetic/pharmacodynamic models; cancer chemotherapy; physiological model; simulations;
The Use of 13C–Erythromycin as an in vivo Probe to Evaluate CYP3A-mediated Drug Interactions in Rats
Keywords: مدل فیزیولوژیکی; cytochrome P450; drug interactions; inhibition; induction; pulmonary; infrared spectroscopy; physiological model
Lengthening of Cardiac Repolarization in Isolated Guinea Pigs Hearts by Sequential or Concomitant Administration of Two IKr Blockers
Keywords: مدل فیزیولوژیکی; drug targeting; drug interaction; In vitro/in vivo correlations (IVIVC); pharmacodynamics; physiological model;
Model-based Decision support in Diabetes Care
Keywords: مدل فیزیولوژیکی; Model-based control system design; Physiological model; System identification; Decision-support system; Clinical trials; Diabetes health care
Preclinical Prediction of Human Brain Target Site Concentrations: Considerations in Extrapolating to the Clinical Setting
Keywords: مدل فیزیولوژیکی; extrapolation; central nervous system (CNS); blood–brain barrier (BBB); blood–cerebrospinal fluid barrier (BCSFB); brain extracellular fluid (ECF); cerebrospinal fluid (CSF); transporters; pharmacokinetics (PK); mathematical model; physiological model
The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation
Keywords: مدل فیزیولوژیکی; hepatic clearance; well-stirred model; parallel tube model; dispersion model; drug ionization; extra- and intracellular water distribution; physiological model; PBPK equation; hepatic uptake and efflux; metabolic elimination; pharmacokinetics;
A three-compartment model of the C-peptide-insulin dynamic during the DIST test
Keywords: مدل فیزیولوژیکی; Insulin sensitivity tests; Compartmental model; Physiological model;
Physiologically based pharmacokinetic model for T84.66: A monoclonal anti-CEA antibody
Keywords: مدل فیزیولوژیکی; pharmacokinetics; physiological model; PBPK; T84.66 anti-CEA antibody; tumor associated antigen; carcinoembryonic antigen (CEA); target mediated disposition; mathematical model; preclinical pharmacokinetics;
A Physiologically Based Pharmacokinetic (PBPK) Model for Predicting the Efficacy of Drug Overdose Treatment With Liposomes in Man
Keywords: مدل فیزیولوژیکی; liposomes; pharmacokinetic/pharmacodynamic models; physiological model; tissue partition; pharmacokinetics; drug transport; dynamic simulation; toxicokinetics; simulations;
Physiologically Based Predictions of the Impact of Inhibition of Intestinal and Hepatic Metabolism on Human Pharmacokinetics of CYP3A Substrates
Keywords: مدل فیزیولوژیکی; physiological model; pharmacokinetics; oral absorption; first-pass effect; cytochrome P450; drug interactions; inhibition;
Fed and fasted gastric pH and gastric residence time in conscious beagle dogs
Keywords: مدل فیزیولوژیکی; gastrointestinal; intestinal absorption; food effect; physiological model; preclinical pharmacokinetics;
Do grooming behaviours affect visual properties of feathers in male domestic canaries, Serinus canaria?
Keywords: مدل فیزیولوژیکی; domestic canary; grooming behaviour; physiological model; plumage coloration; Serinus canaria; visual signal
Physiological modeling and derivation of the rat to human toxicokinetic uncertainty factor for the carbamate pesticide aldicarb
Keywords: مدل فیزیولوژیکی; Aldicarb; Physiological model; Risk assessment; Uncertainty factors
The benefits of using Guyton's model in a hypotensive control system
Keywords: مدل فیزیولوژیکی; Blood pressure; Fuzzy control; Physiological model; Medical systems; Medical applications;
Enhanced parameter estimation methods for noisy SPECT data
Keywords: مدل فیزیولوژیکی; Parameter estimation; Physiological model; Quantitative analysis; Computed tomography; Monte Carlo simulation
Prediction of Drug Tissue to Plasma Concentration Ratios Using a Measured Volume of Distribution in Combination With Lipophilicity
Keywords: مدل فیزیولوژیکی; physiochemical properties; tissue partition; computational ADME; pharmacokinetics; physiological model; distribution; preclinical pharmacokinetics; log P; clinical pharmacokinetics; ADME;
Simulation Modelling of Human Intestinal Absorption using Caco-2 Permeability and Kinetic Solubility Data for Early Drug Discovery
Keywords: مدل فیزیولوژیکی; mathematical model; Caco-2 cells; gastrointestinal transit; in silico modeling; in vitro/in vivo correlations (IVIVC); intestinal absorption; pharmacokinetics; physiological model; solubility; nonlinear pharmacokinetics;
Human physiological models of insomnia
Keywords: مدل فیزیولوژیکی; Primary insomnia; Physiological model; Sleep-wake homeostat; Circadian clock; Stress response