کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486554 | 1114386 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fed and fasted gastric pH and gastric residence time in conscious beagle dogs
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The gastric pH values are controversial in the literature. Some suggest the dog gastric pH is higher than human and dog gastric pH after fed with particular diet is uncertain. Gastric pH in 16 male beagle dogs was measured using Bravo® pH telemetry system. For the fed study, the dogs received 10 or 200Â g of dog dry food (5L18) 15Â min before dosing the Bravo® pH capsule, followed by a 50Â mL of water to aid in swallowing. It was surprising to find a small, but statistically significantly lower pH in the fed compared to the fasted stomach. The average gastric pH in fasted dogs was 2.05 and 1.08 and 1.26 for 10 and 200Â g fed dogs. The average gastric emptying time of the capsule was 1.4, 9.4 and 20Â h for fasted, 10Â g fed and 200Â g fed dogs, respectively. The inter-individual variability was higher in fasted dogs than in fed dogs. The results showed the gastric pH in each colony of dogs can be different from reported values in the literature. It emphasizes that the importance of measuring the pH in each colony when dogs are used to evaluate pharmacokinetics of pH sensitive drugs or formulations. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 7, July 2009, Pages 2494-2500
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 7, July 2009, Pages 2494-2500
نویسندگان
Kazuko Sagawa, Fasheng Li, Ryan Liese, Steven C. Sutton,