کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2484810 1114338 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Issues, challenges, and opportunities in model-based drug development for monoclonal antibodies
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Issues, challenges, and opportunities in model-based drug development for monoclonal antibodies
چکیده انگلیسی

Over the last two decades, there has been a simultaneous explosion in the levels of activity and capability in both monoclonal antibody (mAb) drug development and in the use of quantitative pharmacologic models to facilitate drug development. Both of these topics are currently areas of great interest to academia, the pharmaceutical and biotechnology industries, and to regulatory authorities. In this article, we summarize convergence of these two areas and discuss some of the current and historical applications of the use of mathematical-model-based techniques to facilitate the discovery and development of mAb therapeutics. We also consider some of the current issues and limitations in model-based antibody discovery/development and highlight areas of further opportunity. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2898–2908, 2013

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 9, September 2013, Pages 2898–2908
نویسندگان
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