Keywords: Anti-inflammatory cytokines; Decoy receptors; Inhibitory factors; Innate immunity; Resolution of inflammation; Stress hormones; Toll-like receptor signalling; ACTH; adrenocorticotropic hormone; AP1; activator protein 1; A2M; alpha-2-macroglobulin; CCP; co
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Keywords: γc; common gamma chain, CD132; IL; interleukin; sγc; soluble form of common gamma chain; JAK; Janus-activated kinase; STAT; signal transducer and activator of transcription; T-ALL; T-cell acute lymphocytic leukemia; B-ALL; B-cell acute lymphocytic leuke
Keywords: CASK; calcium/calmodulin-dependent serine protein kinase; COS-7; African green monkey kidney fibroblast-like cell line; Drp1; dynamin-related protein 1; FAK; focal adhesion kinase; hnRNPA2B1; heterogeneous nuclear ribonucleoprotein A2B1; K2P; potassium se
Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Keywords: Inflammation-associated cancer; Ubiquitin-proteasome system (UPS); Small ubiquitin-like modifier (SUMO); Tumor microenvironment; Cytokine profile; Transcription factors; 15d-PGJ2; 15-Deoxy-Delta-12,14-prostaglandin J2; AR; androgen receptor; Ala; alanine;
Ubiquitination/sumoylation: An alternative pathway to modify gene regulation directed by xenosensors
Keywords: Epigenetic regulation; Post-translational modifications; Nuclear receptors; Xenobiotics metabolism; AHR; aryl hydrocarbon receptor; AHRR; aryl hydrocarbon receptor repressor; ARNT; aryl hydrocarbon receptor nuclear translocator; CAR; constitutive androsta
STAT3: The art of multi-tasking of metabolic and immune functions in obesity
Keywords: Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti
The JAK/STAT signaling pathway and photobiomodulation in chronic wound healing
Keywords: AP; activator protein; ATP; adenosine triphosphate; Ca2+; calcium ions; cAMP; cyclic adenosine monophosphate; Cox; cytochrome c oxidase; Cu; copper; Cyto c; cytochrome c; DNA; deoxyribonucleic acid; ECM; extracellular matrix; EGF; epidermal growth factor;
The good and the bad faces of STAT1 in solid tumours
Keywords: BAD; Bcl2-associated agonist of cell death; Bcl; B-cell lymphoma; CD; cluster of differentiation; CDK; cyclin-dependent kinase; CTL; cytotoxic T lymphocyte; CUG; cancer upregulated gene; CXCL; C-X-C motive ligand; DC; dendritic cells; DAMP; danger-associa
Analysis of JAK-STAT signaling pathway genes and their microRNAs in the intestinal mucosa of genetically disparate chicken lines induced with necrotic enteritis
Keywords: JAK; Janus kinase; STAT; signal transducer and activator of transcription; SOCS; suppressor of cytokine signaling; IL; interleukin; RT; reverse transcription; TYK2; tyrosine kinase 2; SH2 (PTPN); src homology 2-containing tyrosine phosphatase 2; PIAS; pro
Sub-cellular localization specific SUMOylation in the heart
Keywords: AMPK; adenosine monophosphate-activated protein kinase; CAMKK; calcium-calmodulin-activated protein kinase kinase; CHIP; carboxyl terminus of HSP70-interacting protein; CVD; cardiovascular disease; cTnI; cardiac troponin I; d-flow; disturbed flow; DeSI; d
Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways
Keywords: SG; Sophoraflavanone G; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositi
TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours
Keywords: TRIM; tripartite motif; RING; really interesting new gene; NHL, NCL-1; HT2A and lin-41; LGMD; limb-girdle muscular dystrophy; XIAP; X-linked inhibitor of apoptosis; PIAS; protein inhibitor of activated STAT; NDRG2; N-myc downstream regulated gene 2; Abi2;
cDNA cloning and expression pattern analysis of protein inhibitor of activated STAT (PIAS) of the mud crab, Scylla paramamosain
Keywords: Scylla paramamosain; PIAS; cDNA Cloning; Expression pattern; Protein expression;
Systems biology of IL-6, IL-12 family cytokines
Keywords: Systems biology; Mathematical modeling; IL-6-type cytokines; Quantitative analyses; Epo; erythropoietin; gp; glycoprotein; hESC; human embryonic stem cells; EGF; epidermal growth factor; ERK; extracellular signal regulated kinase; HGF; hepatocyte growth f
The immune signaling pathways of Manduca sexta
Keywords: Insect immunity; RNA-Seq; Transcriptome; Gene annotation; Expression profiling; Atg; autophagy-related protein; aPKC; atypical protein kinase C; CF; control fat body; CH; control hemocytes; IF; induced fat body; IH; induced hemocytes; Deaf; deformed epide
A novel microRNA regulates osteoclast differentiation via targeting protein inhibitor of activated STAT3 (PIAS3)
Keywords: miRNAs; microRNAs; PIAS3; protein inhibitor of activated STAT3; M-CSF; macrophage colony stimulating factor; RANKL; receptor activator of nuclear factor-κB ligand; RANK; receptor activator of NF-κB; OPG; osteoprotegerin; MAPKs; mitogen-activated protein
NF-κB (p65) negatively regulates myocardin-induced cardiomyocyte hypertrophy through multiple mechanisms
Keywords: SRF; serum response factor; NF-κB; the nuclear factor κB; SUMOs; small ubiquitin-like modifiers; PIAS; protein inhibitors of activated STAT; Pc2; polycomb protein 2; TAD; the transactivation domain; miRNAs; microRNAs; DMEM/F12; Dulbecco's Modified Eagle
Identification of conserved and novel microRNAs in Manduca sexta and their possible roles in the expression regulation of immunity-related genes
Keywords: Posttranscriptional regulation; Illumina sequencing; Lepidoptera; Insect immunity; Target site prediction; Alk; anaplastic lymphoma kinase; AMP; antimicrobial peptides; ANKRD54; ankyrin repeat domain 54; Aop; anterior open; aPKC; atypical protein kinase C
Tuning NF-κB activity: A touch of COMMD proteins
Keywords: CFTR; cystic fibrosis transmembrane conductance regulator; COMMD; copper metabolism gene MURR1 domain-containing protein; CRL; Cullin RING ligase; CRM1; chromosome region maintenance 1/exportin 1; CYLD; cylindromatosis; DUB; deubiquitinating enzyme; ENaC;
Sumoylation regulates nuclear localization and function of zinc finger transcription factor ZIC3
Keywords: ZIC3; SUMO; PIAS; Nuclear import/export;
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis
Keywords: Signal transducer and activator of transcription 1; IFN-γ; progressive multifocal leukoencephalopathy; Histoplasma capsulatum; Coccidioides immitis; thrush; CMC; Chronic mucocutaneous candidiasis; CSF; Cerebrospinal fluid; CT; Computed tomography; DMA; M
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
Keywords: 53BP1; Tp53 binding protein 1; 9-1-1; RAD9-RAD1-HUS1 checkpoint clamp complex; a.a.; amino acid; ACF1; ATP-utilizing chromatin assembly and remodeling factor 1; ALC1; amplified in liver cancer 1; APLF/PALF; aprataxin and PNKP-like factor; Aprataxi
S-Adenosyl Methionine Improves Early Viral Responses and Interferon-Stimulated Gene Induction in Hepatitis C Nonresponders
Keywords: Interferon Signaling; Transcription Factor; Chronic Hepatitis; cEVR; complete early virological response; DMA; dimethyl arginine; ISG; interferon-stimulated gene; ISGF3; interferon-stimulated gene factor 3; JAK; Janus kinase; Mx1; myxovirus resistance pro
A PIAS-ed view of DNA double strand break repair focuses on SUMO
Keywords: SUMO; PIAS; DNA damage response; BRCA1; 53BP1
Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus
Keywords: PRRSV; Interferons; Immune evasion; Immune modulation; NF-κB; CBP degradation; IRF3; PIAS; Nucleocapsid; non-structural proteins; Arterivirus
Functional interaction of AIRE with PIAS1 in transcriptional regulation
Keywords: AIRE; PIAS; SUMO; Insulin promoter; Cystatin B (CSTB) promoter; SP100
PIASy-mediated repression of the Ets-1 is independent of its sumoylation
Keywords: Ets-1; Ets; PIASy; PIAS; SUMO; SUMO-1; SUMO-E3 ligase; Transcription; Repression
Controlling cytokine signaling by constitutive inhibitors
Keywords: Cytokines; JAK/STAT signalling; SOCS; SHP; PIAS; Inhibitors of signaling;
PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein
Keywords: RET finger protein; PIAS; SUMO; Nuclear localization; Transcription;
Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein
Keywords: Papillomavirus; E1; BPV E1; HPV11 E1; sumoylation; E3 ligase; RanBP2; PIAS; Miz1;