LncRNA NEAT1 promotes autophagy in MPTP-induced Parkinson's disease through stabilizing PINK1 protein
Keywords: Parkinson's disease; NEAT1; PINK1; Autophagy;
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PINK1 p.K520RfsX3 mutation identified in a Chinese family with early-onset Parkinson's disease
Keywords: Parkinson's disease; Autosomal recessive early-onset Parkinson's disease; PINK1; Homozygous; Mutation;
PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes
Keywords: PINK1; Parkin; Mitochondria; Metabolic stress;
Mitochondrial quality control pathways: PINK1 acts as a gatekeeper
Keywords: Mitochondria; Quality control; Mitophagy; PINK1;
Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway
Keywords: IRI; ischemia/reperfusion injury; OGD/R; oxygen-glucosedeprivation/reoxygenation; H2; hydrogen; RAP; rapamycin; 3-MA; 3-methyladenine; MTT; 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ROS; reactive oxygen species; MMP; mitochondrial mem
PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction
Keywords: CCCP; PGAM5; DRP1; PINK1; Mitophagy; Mitochondrial dynamics;
Artesunate-induced mitophagy alters cellular redox status
Keywords: ACADVL; very long-chain specific acyl-CoA dehydrogenase; ACC; acetyl-CoA carboxylase 1; ATP; adenosine triphosphate, vacuolar-type H+-ATPase (V-ATPase); COX â
£; cytochrome c oxidase IV; CPS; carbamoyl-phosphate synthase; CQ; chloroquine; GSH; glutathione
Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility
Keywords: Organelle communication; Mitochondria-associated membranes; Nutrients; Microbiome; Innate immunity; Insulin sensitivity; Metabolic diseases; Ca2+; calcium; CLRs; C-type lectin receptors; CypD; cyclophilin D; DAMPs; Danger-Associated Molecular patterns; ER
Characterization of early-onset motor deficits in the Pink1â/â mouse model of Parkinson disease
Keywords: Parkinson disease; Mouse; Ultrasonic vocalization; Pink1;
ROS signalling in the biology of cancer
Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control
Keywords: ALT; Alanine aminotransferase; Drp1; dynamin-related protein 1; EDTA; ethylenediaminetetraacetic acid; GDH; glutamate dehydrogenase; H&E; hematoxylin&eosin; HO-1; heme oxygenase-1; H/R; hypoxia/reoxygenation; IL; interleukin; I/R; ischemia/reperfusion; LP
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants
Keywords: PINK1; DJ1; Human; Mouse; Neurons; Parkinson's disease; Mitochondria; Complexes; AO; with antioxidants; BNGE; blue native gel electrophoresis; CI; complex I; CIII; complex III; CIV; complex IV; DMEM; Dulbecco's Modified Eagle's Medium; FCS; fetal calf ser
Novel and functional ATG12 gene variants in sporadic Parkinson's disease
Keywords: PD; Parkinson's disease; ATG; autophagy-related gene; DSVs; DNA sequence variants; SNCA; alpha synuclein gene; LRRK2; leucine-rich repeat kinase 2; VPS35; vacuolar protein sorting 35; PINK1; PTEN-induced kinase 1; GBA; Glucocerebrosidase; CMA; chaperone-m
PINK1 alleviates myocardial hypoxia-reoxygenation injury by ameliorating mitochondrial dysfunction
Keywords: PINK1; Hypoxia-reoxygenation; Cardiomyocytes; TRAP-1;
Pink1/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury
Keywords: Pink1; Parkin; Mitophagy; Mitochondrial dysfunction; Cisplatin; AKI;
Involvement of PINK1/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging
Keywords: Advanced glycation end products; Cardiac senescence; Mitophagy; Receptor for advanced glycation end products; PINK1;
Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes
Keywords: Parkinson's disease; Non-motor symptoms; PINK1; Parkin; Drosophila; Learning; Memory; Circadian rhythms; Sleep; Electrophysiology; DD; Constant darkness; D/NI; Diurnal/nocturnal index; DA; Dopamine; DAM2; Drosophila Activity Monitor; l-LNv; Large ventral
ReviewParkin and PINK1 functions in oxidative stress and neurodegeneration
Keywords: PINK1; Parkin; Ubiquitin; Neurodegeneration; Oxidative stress; Mitophagy;
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease
Keywords: PINK1; α-Synuclein; Kinetin; Neurodegeneration; Parkinson's disease; Adeno-associated virus; AAV;
ReviewDysregulated microRNAs in neural system: Implication in pathogenesis and biomarker development in Parkinson's disease
Keywords: PD; Parkinson's disease; DA; dopaminergic; SN; substantia nigra; LRRK2; leucine repeat kinase 2; PINK1; PTEN-Induced Putative Kinase 1; ROS; reactive oxidative stress; AD; Alzheimer's disease; MPTP; methyl-4-phenyl-1,2,3,6-tetrahydropyridine; c/EBP-al
Expanding perspectives on the significance of mitophagy in cancer
Keywords: ALS; amyotrophic lateral sclerosis; AR; androgen receptor; ASC; apoptosis-associated speck-like protein containing a CARD; ATM; ataxia telangiectasia mutated; BCL-2; breakpoint cluster locus-2; BCL-XL; BCL2-like 1 long; BNIP3; BCL2 interacting protein 3;
Role of PARL-PINK1-Parkin pathway in adipocyte differentiation
Keywords: Adipogenesis; Parkin; Peroxisome proliferator-activated receptor-γ (PPARγ); Presenilin associated rhomboid-like protein (PARL); PTEN-induced kinase 1 (PINK1); C/EBPα/β; CCAAT-enhancer-binding protein-α/â β; DRP1; dynamin-related protein-1; FABP4;
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells
Keywords: Annexin V; FITC-conjugated annexinV; BCA; bicinchoninic acid; BNIP3; Bcl2/adenovirus E1B 19Â kDa protein-interacting protein 3; CBP; CREB-binding protein; CCCP; carbonyl cyanide m-chlorophenyl hydrazine; CHIP; chromatin immunoprecipitation; CHOP; CCAAT-en
An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle
Keywords: CAT; catalase; COX; cytochrome c oxidase; DJ7; Parkinson 7; DNM1L; dynamin-1-like protein; FIS1; mitochondrial fission protein 1; MFF; mitochondrial fission factor; MFN1; mitofusin-1; MFN2; mitofusin-2; mtDNA; mitochondrial DNA; mtNOD; C57BL/6NTac-mtNODLt
Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability
Keywords: OMM; outer mitochondrial membrane; DRP1; dynamin-related protein-1; MFN1; mitofusin 1; MFN2; mitofusin 2; mtDNA; mitochondrial DNA; PINK1; PTEN-induced putative kinase 1; PARK2; parkin; DOA; dominant optic atrophy; CMT2A; Charcot-Marie-Tooth neuropathy ty
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Keywords: AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;
Regulation of autophagy by mitochondrial phospholipids in health and diseases
Keywords: ALCAT1; lysocardiolipin acyltransferase 1; ALE1; lysophospholipid acyltransferase (yeast); AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATGL; adipose triglyceride lipase; AVT1; amino acid vacuolar transport; BNIP3; BCL2/adenovirus E1B
Expression and purification of the kinase domain of PINK1 in Pichia pastoris
Keywords: Heterologous expression; PINK1; Pichia pastoris; Parkinson's disease; Ubiquitin
Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson’s patients and genotype-phenotype correlations
Keywords: Parkinsonism; PARK loci; PRKN; PINK1; DJ1; SNCA
PINK1 alleviates palmitate induced insulin resistance in HepG2 cells by suppressing ROS mediated MAPK pathways
Keywords: PINK1; Insulin resistance; ROS; JNK; ERK; HepG2 cells;
Analysis of mitochondrial structure and function in the Drosophila larval musculature
Keywords: ATP; adenosine triphosphate; AEL; after egg laying; CMT2A; Charcot-Marie-Tooth Type 2A; ConA; concanavalin A; Drp1; dynamin-related protein; DOA; dominant optic atrophy; GFP; green fluorescent protein; IFM; indirect flight muscle; IMF; intermyofibrill
Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice
Keywords: PINK1; Electrophysiology; Endocannabinoid; Dopamine; Striatum; Parkinson's disease
Decorin as a multivalent therapeutic agent against cancer
Keywords: AMPKα; AMP-activated protein kinase, alpha; AP4; Activating enhancer binding protein 4; ATG; Autophagy-related gene; Bcl2; B-cell CLL/lymphoma 2; BRAF; Proto-oncogene B-Raf; ECM; Extracellular matrix; EGFR; Epidermal growth factor receptor; ERK; Extracel
Pexophagy and peroxisomal protein turnover in plants
Keywords: AAA; ATPase associated with diverse cellular activities; ATG; autophagy related; ER; endoplasmic reticulum; IAA; indole-3-acetic acid; IBA; indole-3-butyric acid; ICL; isocitrate lyase; LIR; LC3-interacting region; MLS; malate synthase; NBR1; Neighbor of
PPAR-γ activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction
Keywords: Deltamethrin; Rosiglitazone; Mitochondrial dysfunction; PINK1; Apoptosis;
Atp13a2 expression in the periaqueductal gray is decreased in the Pink1 -/- rat model of Parkinson disease
Keywords: Parkinson disease; Rat; Pink1; Periaqueductal gray; Ultrasonic vocalization; Alpha synuclein; Atp13a2; Gad1;
PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy
Keywords: PGC-1α; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; FoxO; forkhead box O; 4-HNE; 4-hydroxynonenal; Mul1; mitochondrial E3 ubiquitin protein ligase 1; PINK1; PTEN-induced putative kinase 1; Mfn2; mitofusin 2; mROS; mitochondrial
Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
Keywords: Parkin; PINK1; USP30; Mitophagy; Parkinson's Disease;
Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion
Keywords: BN-PAGE; blue native polyacrlamide gel electrophoresis; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; CM-H2DCFDA; chloromethyl derivative of 2â²,7â²-dichlorodihydrofluorescein diacetate; Drp1; dynamin related protein 1; DTT; 1,4-dithiothreitol; ER; e
Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism
Keywords: ARE; antioxidant response element; ATP; adenosine triphosphate; 5-hmC; hydroxymethylcytosine; ATG; AuTophaGy related; BNIP; Bcl-2/adenovirus E18 19-kDa-interacting protein; Drp1; dynamin related protein 1; EpRE; electrophile response element; eNOS; endoth
Autophagy machinery in the context of mammalian mitophagy
Keywords: PINK1; PTEN-induced putative kinase 1; CCCP; carbonyl cyanide m-chlorophenylhydrazone; OMM; outer mitochondrial membrane; ATG; autophagy-related; ULK1; unc-51 like kinase 1; FIP200; focal adhesion kinase family interacting protein of 200Â kDa; mTor; mecha
Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria
Keywords: PINK1; Parkin; Activation; E3; Ubiquitin;
Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans
Keywords: Caenorhabditis elegans; Heteroplasmy; Mitochondria; mtDNA; Parkin; PINK1;
Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury
Keywords: Transient global ischemia; Hippocampus; PINK1; Drp1;
Pyruvate stimulates mitophagy via PINK1 stabilization
Keywords: PDK4; Pyruvate; Mitophagy; PARK2; PINK1; LC3;
Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1–AMPK signaling and autophagy
Keywords: PTEN; Pink1; AMPK; Cardiac hypertrophy; Contractile function
Mitophagy and mitochondrial dynamics in Saccharomyces cerevisiae
Keywords: AIM; Atg8 family interacting motif; ALP; alkaline phosphatase; Ape1; aminopeptidase I; ATG; autophagy-related; CCCP; carbonyl cyanide m-chlorophenylhydrazone; CJ; crista junction; CM; cristae membrane; CMA; chaperone-mediated autophagy; Cvt; cytoplasm to
Differential submitochondrial localization of PINK1 as a molecular switch for mediating distinct mitochondrial signaling pathways
Keywords: Parkinson disease; PINK1; Parkin; TRAP1; Three-dimensional structured illumination microscopy;
GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
Keywords: 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3â²,5â²-cyclic adenosine monophosphate;