Role and regulation of PI3K in sperm capacitation and the acrosome reaction
Keywords: Spermatozoa; Capacitation; Acrosome reaction; PI3K; PKA; PKC
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Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxylase
Keywords: AADase, acetoacetate decarboxylase; CaAAD, Clostridium acetobutylicum AADase; CvAAD, Chromobacterium violaceum AADase; LPB equation, linear Poisson–Boltzmann (LPB) equation; MC method, Monte Carlo method; PDB, protein data bankLysine; pKa; Acetoacetate de
Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel
Keywords: TRPV4; PKA; PKC; Phosphorylation; Sensitization; Hyperalgesia
Titin-based regulations of diastolic and systolic functions of mammalian cardiac muscle
Keywords: SL; sarcomere length; PKA; protein kinase A; Myocardium; Sarcomere; Connectin; Ca2+;
Mechanism of hCG-induced spermiation in the toad Rhinella arenarum (Amphibia, Anura)
Keywords: Spermiation; Toad; PKA; hCG; Na+/K+ ATPase
Bisubstrate fluorescent probes and biosensors in binding assays for HTS of protein kinase inhibitors
Keywords: ARC; adenosine analogue-oligoarginine conjugate; CHO; Chinese Hamster Ovary; EFC; enzyme fragment complementation technology; FA; fluorescence anisotropy; FITC; Fluorescein isothiocyanate; FRET; Förster-resonance energy transfer; GST; glutathione S-tra
Fast high-throughput method for the determination of acidity constants by capillary electrophoresis. II. Acidic internal standards
Keywords: Acidity constant; Capillary electrophoresis; pKa; Internal standard; High throughput method
Beta-2 adrenergic receptor mediated ERK activation is regulated by interaction with MAGI-3
Keywords: βARs; beta-adrenergic receptors; PKA; protein kinase A; CT; carboxyl terminus; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular signal-regulated kinase; GPCRs; G-protein-coupled receptors; GST; glutathione S-transferase; His; hexahistidin
A generalized numerical approach to steady-state enzyme kinetics: Applications to protein kinase inhibition
Keywords: DYNAFIT; Protein Kinase; Inhibition; p56lck tyrosine kinase; PKA; Bisubstrate analog; Enzyme kinetics; Theory; Steady state approximation;
Synergism of theophylline and anticholinergics to inhibit haloperidol-induced catalepsy: A potential treatment for extrapyramidal syndromes
Keywords: AC; adenylyl cyclase; ACh; acetylcholine; A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; ANOVA; analysis of variance; BENZ; benztropine; CDT; cumulative descent time; CNS; central nervous system; DMSO; dimethylsulphoxyde; DPCPX; 8-cyclopentyl-1
Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner
Keywords: Morphine; PGE2; PKA; CGRP release; DRG neurons; Opioid-induced hyperalgesia; Gs protein signaling
Cyclic AMP Inhibits IL-1β Plus IFNγ-Induced NF-κB Translocation in Hepatocytes by a PKA Independent Mechanism
Keywords: cyclic AMP; IKK; NF-κB; hepatocyte; PKA
Status epilepticus alters hippocampal PKAβ and PKAγ expression in mice
Keywords: PKA; Mouse; Hippocampus; Status epilepticus
Shrinking and development of lipid droplets in adipocytes during catecholamine-induced lipolysis
Keywords: ATGL; adipose triglyceride lipase; BSA; bovine serum albumin; DIC; differential interference contrast; FFA; free fatty acid; HSL; hormone-sensitive lipase; LD; lipid droplet; PBS; phosphate-buffered saline; PKA; protein kinase A; SVC; stromal-vascular cel
Calculation of pKa values of carboxylic acids: Application to bilirubin
Keywords: Bilirubin; Bilitranslocase; pKa; Membrane transport; Abinitio;
Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic β-cells
Keywords: cAMP; Epac; Exendin-4; Pancreatic β-cell; PKA; TxNIP
Depolarization induces acetylation of histone H2B in the hippocampus
Keywords: histone acetylation; CaM kinase; ERK; DNA methyltransferase; aCSF; artificial cerebrospinal fluid; CaMK; calcium/calmodulin-dependent kinase; CS; cutting saline; DNMT; DNA methyltransferase; ERK; extracellular signal regulated kinase; HDAC; histone deacet
Research ArticlePancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation
Keywords: PDX-1; Pancreatic Duodenal Homeobox-1; NRC; normal rat cultured cholangiocytes; BDL; bile duct ligation; cAMP; cyclic adenosine 3â²,5â²-monophosphate; FBS; fetal bovine serum; PKA; protein kinase A; PI3K; phosphatidyl-inositol-3-kinase; PCNA; proliferat
Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152
Keywords: cochlea; high content analysis; neurite; regeneration; Rho kinase; spiral ganglion; BDNF; brain derived neurotrophic factor; BMP4; bone morphogenetic protein 4; DMEM/F12; Dulbecco's modified Eagles medium/Hams F12(1:1); H-1152; (S)-(+)-2-Methyl-1-[(4-meth
New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-1 (GLP-1)
Keywords: cAMP; cat/TCF; Diabetes; Epac; GLP-1; PKA; Wnt;
An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1
Keywords: BKCa; big conductance Ca2+-activated K+-channel (KCa1.1); Clotrimazole; 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole; CsA; Cyclosporin A; DC-EBIO; 5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one; DMEM; Dulbecco's modified Eagle medium; ER; endopla
Phosphorylation of contractile proteins in response to α- and β-adrenergic stimulation in neonatal cardiomyocytes
Keywords: cAMP; cyclic AMP; cTnI; cardiac troponin I; DMEM; Dulbecco's modified eagle medium; F; fluorescence; iso; isoproterenol; MyBP-C; myosin binding protein-C; MyBP-C-P1; monophosphorylated MyBP-C; RCM; neonatal rat cardiomyocyte; PKA; protein kinase A; PLB;
Solubility and pKa of select pharmaceuticals in water, ethanol, and 1-octanol
Keywords: Experimental solubility; pKa; Drugs + water, ethanol, 1-octanol; Thermodynamic correlation
Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis
Keywords: Drug-induced phospholipidosis; Cationic amphiphilic drug; Principal component analysis; Phospholipid vesicle; Rat liver microsome; Phospholipase A2; pKa; Partition coefficient
Effects of extraction procedures on metal binding properties of extracellular polymeric substances (EPS) from anaerobic granular sludges
Keywords: Extracellular polymeric substances; Extraction method; Binding properties; pKa; Pb; Cd
pKa modeling and prediction of a series of pH indicators through genetic algorithm-least square support vector regression
Keywords: pKa; pH indicators; Quantitative structure–property relationships; Support vector machines; GA-LSSVR
Combined effect of polarity and pH on the chromatographic behavior of some angiotensin II receptor antagonists and optimization of their determination in pharmaceutical dosage forms
Keywords: Angiotensin II receptor antagonist; Chromatographic retention modelling; LC; Polarity parameter; pKa; Method validation
Nucleophile activation in PD…(D/E)xK metallonucleases: An experimental and computational pKa study
Keywords: Metallonuclease; pKa; Mechanism
Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells
Keywords: SH-SY5Y; NMDA receptor; L-type calcium channel; T-type calcium channel; PKA; PKC
Gibbs energies of formation of chlorinated benzoic acids and benzoates and application to their reductive dechlorination
Keywords: Enthalpy of formation; Gas-phase acidity; pKa; Gibbs energy; Chlorinated benzoic acids; Chlorinated benzoates;
The interplay between chromogranin A-derived peptides and cardiac natriuretic peptides in cardioprotection against catecholamine-evoked stress
Keywords: CgA; chromogranin A; CAs; catecholamines; NPs; natriuretic Peptides; VS-1; vasostatin 1; Cts; catestatin; rCgA1-64; rat CgA1-64; hrSTACgA1-78; human recombinant STACgA1-78; VSs; vasostatins; ET-1; endothelin 1; HPA; hypothalamus-pituitary-adrenal
Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes
Keywords: SR; sarcoplasmic reticulum; RyR; ryanodine receptor; SERCA; sarcoplasmic reticulum Ca2+ ATPase; ATP; adenosine triphosphate; PLB; phospholamban; HCM; hypertrophic cardiomyopathy; FHC; familial hypertrophic cardiomyopathy; DCM; dilated cardiomyopathy; MYH7
Elevated extracellular calcium increases fibroblast growth factor-2 gene and protein expression levels via a cAMP/PKA dependent pathway in cementoblasts
Keywords: Extracellular calcium; Cementoblast; FGF-2; PKA; cAMP
Long-term potentiation of neuronal excitation in the central nucleus of the rat amygdala revealed by imaging with a voltage-sensitive dye
Keywords: Pain; Plasticity; PKA; Optical imaging
(d)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Iα
Keywords: cGMP; cyclic guanosine 3â²,5â²-mono-phosphate; i.p.; intraperitoneal; i.v.; intravenous; Ki; inhibition constant; MAP; mean arterial blood pressure; Km; Michaelis-Menten constant; MPP; membrane-permeable peptides; PKA; cAMP-dependent protein kinase; P
Protein kinase A-mediated phosphorylation of the RASSF1A tumour suppressor at Serine 203 and regulation of RASSF1A function
Keywords: RASSF1A; Tumour suppressor; PKA; Phosphorylation; Apoptosis;
Adenylate Cyclase 1 modulates peripheral nerve branching patterns
Keywords: AC1; adenylate cyclase 1; DRG; dorsal root ganglia; LGN; lateral geniculate nucleus; LMC; lateral motor column; LMCl; lateral motor column lateral; LMCm; lateral motor column medial; MMC; medial motor column; MMCl; medial motor column lateral; MMCm; media
Protolytic fluorescein species evaluated using chemometry and DFT studies
Keywords: Fluorescein; Xanthene; pKa; Principal component analysis; Density functional theory; Chemometry
Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway
Keywords: Succinate; Cardiomyocytes; Calcium; PKA;
Proton transfer function of carbonic anhydrase: Insights from QM/MM simulations
Keywords: Carbonic anhydrase; Proton transfer; pKa; QM/MM; Electric field gradient; Grotthus; Proton hole
The effect of midazolam on mouse Leydig cell steroidogenesis and apoptosis
Keywords: Midazolam (Dormicum®); Leydig cell; Steroidogenesis; PBR; StAR; P450scc; 3β-HSD; PKA; PKC; Flumazenil (Anexate®); Cell death
Determination of pKa values of some antihypertensive drugs by liquid chromatography and simultaneous assay of lercanidipine and enalapril in their binary mixtures
Keywords: Enalapril; Lercanidipine; Ramipril; pKa; Liquid chromatography; Determination
Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex
Keywords: electron microscopy; dendritic spines; D1; D5; protein phosphatase-1; dopamine; AC; adenylyl cyclase; ANOVA; analysis of variance; CaM; calmodulin; cAMP; cyclic AMP; Cdk5; cyclin-dependent kinase 5; DAB; 3,3â²-diaminobenzidine; DARPP-32; dopamine- and cA
Pro-inflammatory responses in human monocytes are β1-adrenergic receptor subtype dependent
Keywords: ARs; adrenergic receptors; Bmax; maximal specific binding of radioligand; CGP 20712A; [1-(2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate, 2-hydroxy-5-(2-(hydroxy-3-(4-((1-m
Localised Ca channel phosphorylation modulates the distribution of L-type Ca current in cardiac myocytes
Keywords: T-tubules; Phosphorylation; L-type Ca channel; Myocytes; PKA; CaMKII;
Acute Ca2+-dependent desensitization of 5-HT1A receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons
Keywords: calcium current; desensitization; 5-hydroxytryptamine; PKA; phosphatase; serotoninAC, adenylyl cyclase; AR, agonist ratio; BAPTA, ethylenedioxybis(o-phenylenenitrilo) tetraacetic acid; cAMP, cyclic adenosine monophosphate; DMSO, dimethyl sulfoxide; DP-5-C
Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK
Keywords: PGE2; PKA; ERK; CREB; Brain tumors
DFT studies of β-elimination reactions in water solution with different bases: Theory vs experiment
Keywords: Elimination reaction; DFT; pKa; Transition state;
A Novel Prodrug Strategy for β-Dicarbonyl Carbon Acids: Syntheses and Evaluation of the Physicochemical Characteristics of C-Phosphoryloxymethyl (POM) and Phosphoryloxymethyloxymethyl (POMOM) Prodrug Derivatives
Keywords: β-dicarbonyl carbon acids; phosphate prodrug derivatives; in vitro bioconversion; pKa; pH-rate profile;
Differential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retina
Keywords: PKA; immunohistochemistry; PDE; CNG; Rap; H89; BCA; bicinchoninic acid; cAMP; cyclic AMP; cDNA; complimentary DNA; cGMP; cyclic guanosine monophosphate; ChAT; choline acetalytransferase; CNB; cyclic nucleotide binding site; CNG; cyclic nucleotide gated ch