دانلود مقالات ISI درباره Pka + ترجمه فارسی

Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling

Keywords: ACTH; adrenocorticotropic hormone; cAMP; cyclic 3′,5′-adenosine monophosphate; AGRP; agouti-related protein; CTX; cholera toxin; ER; endoplasmic reticulum; ERK-1/2; extracellular signal-regulated kinases; FSK; forskolin; GPCR; G protein-coupled recept

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells

Keywords: PACAP; pituitary adenylate cyclase-activating polypeptide; PAC1; PACAP type 1 receptor; ic3; third intracellular loop; VIP; vasoactive intestinal polypeptide; STC1; stanniocalcin 1; GPCR; G protein-coupled receptor; AC; adenylate cyclase; PKA; protein kin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Biorelevant pKa (37 °C) predicted from the 2D structure of the molecule and its pKa at 25 °C

Keywords: Ionization constant; pKa; Abraham's descriptors; Biorelevant media; Linear free energy relationships

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes

Keywords: AKAP; A kinase anchoring protein; βAR; beta adrenergic receptor; cAMP; cyclic adenosine monophosphate; Cav-3; caveolin-3; PKA; protein kinase A; CGP; CGP20712A; Epac2; exchange protein activated by cAMP; EPR; E-type prostaglandin receptor; FRET; fluoresc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Activity and function of rabbit muscle-specific creatine kinase at low temperature by mutation at gly268 to asn268

Keywords: CK; creatine kinase; PCr; phosphocreatine; Cr; creatine; M-CK; muscle-specific creatine kinase; RM-CK; rabbit muscle-specific creatine kinase; M1-CK (M2-CK M3-CK); carp muscle-specific creatine kinase subisoform 1 (2, 3); DTT; 1,4-dithio-DL-threitol; dADP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Several agents and pathways regulate lipolysis in adipocytes

Keywords: Lipolysis; Adipose tissue; Intracellular signalling pathways; Hormone-sensitive lipase; Adipose triglyceride lipase; Antilipolysis; ACTH; adrenocorticotrophin hormone; AdPLA; adipose-specific phospholipase A2; Ang II; angiotensin II; ANP; atrial natriuret

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

CoPK32 is a novel stress-responsive protein kinase in the mushroom Coprinopsis cinerea

Keywords: CaMK; Ca2+/calmodulin-dependent protein kinase; MAPK; mitogen-activated protein kinase; MAPKAPK; mitogen-activated protein kinase-activated protein kinase; MBP; myelin basic protein; PKA; cAMP-dependent protein kinase; Basidiomycetes; Coprinopsis cinerea

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia

Keywords: G protein-coupled receptor kinase 2; PKA; PKCε; Allodynia; Chronic pain;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Adrenocorticotropin hormone (ACTH) effects on MAPK phosphorylation in human fasciculata cells and in embryonic kidney 293 cells expressing human melanocortin 2 receptor (MC2R) and MC2R accessory protein (MRAP)β

Keywords: DAPI; 4′,6′-diamino-2-phenylindole dihydrochloride; ACTH; adrenocorticotropin hormone; Rp-cAMPS; adenosine-3-5-cyclic monophosphorothioate, Rp isomer; BFA; brefeldin A; Epac; exchange protein directly activated by cAMP; ERK; extracellular regulated re

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Characterization of the regulatory subunit of Yarrowia lipolytica cAMP-dependent protein kinase. Evidences of a monomeric protein

Keywords: Yarrowia lipolytica; PKA; Regulatory subunit; Autophosphorylation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Cooperativity and allostery in cAMP-dependent activation of Protein Kinase A: Monitoring conformations of intermediates by amide hydrogen/deuterium exchange

Keywords: BME; β-mercaptoethanol; cAMP; cyclic 3′5′adenosine monophosphate, C, catalytic subunit of cAMP-dependent protein kinase; R; regulatory subunit of cAMP-dependent protein kinase; PKA; cAMP-dependent protein kinase, Protein Kinase A; RIα(92-379); del

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Regulation of the immune response and inflammation by histamine and histamine receptors

Keywords: Histamine receptor; innate immunity; adaptive immunity; immune regulation; G protein-coupled receptor; review; cAMP; Cyclic adenosine monophosphate; DC; Dendritic cell; EPAC; Exchange protein directly activated by cyclic adenosine monophosphate 1; Foxp3

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Solubility and pKa determination of six structurally related phenothiazines

Keywords: Phenothiazine derivatives; Experimental solubility; pKa; Drugs + water, ethanol, 1-octanol solvents; Thermodynamic correlation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Ghrelin-induced activation of cAMP signal transduction and its negative regulation by endocannabinoids in the hippocampus

Keywords: CREB phosphorylation; NR1; PKA; Anandamide; 2-AG; CB1; TRPV; F-actin; Phalloidin; CA1; Immunohistochemistry

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and photophysical properties of 2,6-dicyano-p-phenylenediamine

Keywords: Solvatochromism; 2,6-Dicyano-p-phenylenediamine; Photophysical properties; pKa; pKa*

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

Keywords: Guanine nucleotide exchange factors; cAMP; PKA; CaMKII; Phosphodiesterase; Compartmentation; G protein-coupled receptor

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Nuclear β-adrenergic receptors modulate gene expression in adult rat heart

Keywords: AC; adenylyl cyclase; ATP; adenosine triphosphate; βAR; β-adrenergic receptor; CAMKII; Ca2+/calmodulin-dependent protein kinase II; DNA; deoxyribonucleic acid; DTT; dithiothreitol; ET-1; endothelin 1; ERK; extracellular signal-regulated kinase; GPCR; G

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89

Keywords: AKAPs; anchoring kinase cAMP proteins; BSA; bovine serum albumin; DMPK; myotonin protein kinase; KCN; potassium cyanide; PCP; pentachlorophenol; PDVF; poly (vinylidene difluoride); PKA; protein kinase cAMP dependent; PKC; protein kinase C; PKI; protein ki

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Autophagy as a therapeutic target in cardiovascular disease

Keywords: Heart failure; Cardiac hypertrophy; Remodeling; Autophagy; Plasticity; HDAC inhibitors; Hypertrophy; AMPK; IP3; mTOR; PKA; p53

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Increased synapsin expression and neurite sprouting in lamprey brain after spinal cord injury

Keywords: Petromyzon marinus; PKA; Phospho-synapsin; Synaptic vesicle; Synapsin; Synaptogyrin; Synaptoporin; VAMP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Serine phosphorylation regulates disabled-1 early isoform turnover independently of Reelin

Keywords: ApoER2; apolipoprotein E receptor 2; CsA; cyclosporine A; Cdk; cyclin dependent kinase; Dab1; Disabled-1; CHX; cycloheximide; CPTS; 3,4',4″,4-copper phthalocyanine tetrasulfonic acid, tetrasodium salt; CsA; cyclosporine A; ED; embryonic day; GSK3; glyco

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate

Keywords: inflammation; lipopolysaccharide; microglia; APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); chelerythrine chloride; 1,2-dimethoxy-N-methyl(1,3)benzo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Age-related β-adrenergic receptor-mediated vasorelaxation is changed by altering G protein receptor kinase 2 expression

Keywords: AKAP; A kinase anchoring protein; adeno; Adenovirus; β-AR; Beta-adrenergic receptor; BCA; Bicinchoninic acid; ED50; Effective dose 50% response; EV; Empty adenovirus vector; ECL; Enhanced chemiluminescence; FSK; Forskolin; GRK; G protein receptor kinase;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Cordyceps militaris extract stimulates Cl− secretion across human bronchial epithelia by both Ca2+- and cAMP-dependent pathways

Keywords: AC; adenylate cyclase; AM; acetoxymethylester; BAPTA; 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; CaCC; calcium-activated Cl− channel; cAMP; cyclic adenosine monophosphate; CFTR; cystic fibrosis transmembrane conductance regulator; CFT

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Transglutaminase 2 regulates early chondrogenesis and glycosaminoglycan synthesis

Keywords: Chondrocyte; Mesenchymal cells; Transglutaminase 2; Glycosaminoglycan; PKA; Cell differentiation

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

PKA and Epac synergistically inhibit smooth muscle cell proliferation

Keywords: Epac; PKA; Rap1; cAMP; Proliferation; Vascular smooth muscle cell;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats

Keywords: AC; adenylate cyclase; AKT; protein kinase B; cAMP; cyclic adenosine 3′,5′-monophosphate; CB; cytochalasin B; EFB-1; 2-(2-fluorobenzamido)benzoic acid ethyl ester; FMLP; formyl-l-methionyl-l-leucyl-l-phenylalanine; GPCR; G-protein-coupled receptor; IB

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

PKCθ activation in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors is needed for stimulation of numerous important cellular signaling cascades

Keywords: CCK; COOH-terminal octapeptide of cholecystokinin; TPA; 12-O-tetradecanoylphorbol-13-acetate; GI; gastrointestinal; CCK-JMV; CCK-JMV-180; IP; immunoprecipitation; Co-IP; co-immunoprecipitation; PKD; protein kinase D; GPCR; G protein-coupled receptor; PYK2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Cigarette smoking, cyclooxygenase-2 pathway and cancer

Keywords: AA; arachidonic acid; PLA2; phospholipase A2; COX; cyclooxygenase; PGE2; prostaglandin E2; TxA2; thromboxane A2; TxB2; thromboxane B2; PGI2; prostacyclin; PGES; prostaglandin E synthase; TxAS; thromboxane synthase; PGIS; prostacyclin synthase; GPCR; G-pro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Pain and analgesia: The dual effect of nitric oxide in the nociceptive system

Keywords: 7-NI; 7-nitroindazole; AA; arachidonic acid; Ach; acetylcholine; AG; aminoguanidine hemisulfate; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP; adenosine triphosphate; CFA; complete Freund's adjuvant; cGMP; cycl

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Cellular mechanisms of acute decrease of glutamate release induced by raloxifene in rat cerebral cortex

Keywords: Raloxifene; Glutamate release; Synaptosomes; Voltage-dependent Ca2+ channels; ERK; Synapsin I; 4-AP; 4-aminopyridine; [Ca2+]C; cytosolic free Ca2+ concentration; DiSC3(5); 3′,3′,3′-dipropylthiadicarbocyanine iodide; DL-TBOA; DL-threo-beta-benzyl-oxy

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular determinants and feedback circuits regulating type 2 CRH receptor signal integration

Keywords: CRH receptor; PKA; Ucn2; β-arrestin1; ERK1/2; AKAP;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Attention deficit induced by blockade of N-methyl d-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3

Keywords: NMDA receptor antagonist; LY379268; glutamate release; p-S133CREB; 5-choice serial reaction time task; attention; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; CPu; caudate-putamen; CREB; cAMP response element binding protein; FC; fro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

A Molecular Basis for Interactions Between Sleep and Memory

Keywords: cAMP; PKA; CREB; Learning; Memory; NREM; REM; Oscillation;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

NMR and amber analysis of the neamine pharmacophore for the design of novel aminoglycoside antibiotics

Keywords: Aminoglycoside; Neamine; NMR; AMBER; Molecular dynamics; Clustering; Exchange rate constants; pKa; Transition state analysis; Boltzmann’s distribution lawnea33/65/74, neamine at pD 3.3/6.5/7.4; nea65p/s, the primary/secondary neamine species at pD 6.5; ne

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Lipolysis - A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

Keywords: 2-AG; 2-arachidonoyl glycerol; ABHD1-15; α/β hydrolase domain containing protein 1-15; ARF1; ADP-ribosylation factor 1; ATGL; adipose triglyceride lipase; BAT; brown adipose tissue; BiFC; bimolecular fluorescence complementation; CDS; Chanarin-Dorfman

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas

Keywords: Cannabinoids; Cannabinoid receptors; Food intake; Obesity; Insulin secretion; Islets of Langerhans; β-cells; AC; adenylate cyclase; ACEA; N-(2-chloroethyl)5,8,11,14-eicosaetraenamide; AEA; N-arachidonoyl ethanolamine; 2-AG; 2-arachidonoyl glycerol; AM251

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Activation of cAMP Signaling Interferes with Stress-Induced p53 Accumulation in ALL-Derived Cells by Promoting the Interaction between p53 and HDM2

Keywords: BCP-ALL; B-cell precursor acute lymphoblastic leukemia; IR; ionizing radiation; Epac; exchange protein directly activated by cAMP; PKA; protein kinase A;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2

Keywords: AACOCF3; arachidonyl trifluoromethyl ketone; AC; adenylate cyclase; AGC; cAMP-dependent protein kinase A/protein kinase G/protein kinase C; BMM; bone marrow-derived macrophages; CAPE; caffeic acid phenethyl ester; COX; cyclooxygenase; cPLA2; cytosolic pho

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular mechanisms of human lipodystrophies: From adipocyte lipid droplet to oxidative stress and lipotoxicity

Keywords: AC; adenyl cyclase; AGPAT2; 1-acylglycerol-3-phosphate-O-acyltransferase 2; AT; adipose tissue; ATGL; adipose triglyceride lipase; BSCL; Berardinelli-Seip congenital lipodystrophy; C/EBP; CCAAT/enhancer binding protein; CGI-58; comparative gene identifica

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?

Keywords: BPV; bovine papillomavirus; BRAP2; BRCA1-associated protein 2; CAV; chicken anaemia virus; CBP; CREB binding protein; Cdk; cyclin dependent kinase; CK1; protein kinase CK1; CK2; protein kinase CK2; Crm1; chromosome region maintenance protein 1; CTD; C-ter

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats

Keywords: cocaine addiction; postmortem human brain; rat brain; Fas-FADD complex; PARP-1 cleavage; apoptotic signaling; AIF; apoptosis-inducing factor; Akt/PKB; v-akt murine thymoma viral oncogene homologue/protein kinase B; Bax; Bcl-2 associated X protein; Bcl-2

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?

Keywords: 2 DE; 2D gel electrophoresis; 2DPAGE; 2D polyacrylamide gel electrophoresis; AIF; Apoptosis inducing factor; Apaf-1; Apoptotic protease activating factor 1; APC; Antigen presenting cell; ASK-1; Apoptosis Signal-regulating Kinase 1; Bag; Bcl-2-associated a

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: A review

Keywords: 13C NMR; carbon nuclear magnetic resonance; 1H NMR; proton nuclear magnetic resonance; ADME; absorption distribution metabolism elimination; AID; adjuvant induced disease; AUC; plasma-time curve; BBB; blood-brain barrier; BMC; biopartitioning micellar

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Hypothalamic interaction with the mesolimbic DA system in the control of the maternal and sexual behaviors in rats

Keywords: 15HO; hysterectomy and ovariectomy on day 15 of pregnancy; BLA; basolateral amygdala; cAMP; cyclic AMP; CPP; conditioned place preference; CREB; cyclic AMP response element binding protein; DA; dopamine; E2; water soluble estradiol; E; estradiol; EB; estr

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2011 سفارش ترجمه

A new property of twitchin to restrict the “rolling” of mussel tropomyosin and decrease its affinity for actin during the actomyosin ATPase cycle

Keywords: Mollusc catch muscle; Twitchin; Ghost muscle fibers; ATPase cycle; Actomyosin intermediate states; Polarized fluorescence; S1; myosin subfragment-1; TM; tropomyosin; TN; troponin complex; IAF; 5-iodoacetamido fluorescein; DTT; dithiothreitol; PKA; cAMP-de

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability

Keywords: Neuronal nitric oxide synthase; Selective inhibitors; Increased membrane permeability; pKa

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of a sulfonamide series of CCR2 antagonists

Keywords: CCR2 antagonists; pKa; Sulfonamides

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes

Keywords: PKA; NOS1; Phospholamban; Phosphatase;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Keywords: Akt; Kinase; Selectivity; Oral; PKA

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه