Keywords: پنومولیسین; AEs; adverse events; ELISA; enzyme-linked immunosorbent assay; SD; standard deviation; TEAEs; treatment emergent adverse events; TMB; 3,3â²,5,5â²-tetramethylbenzidine; EPT; end-point titre; MSD; mesoscale discovery; ECL; electrochemiluminescence; Ply; p
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Keywords: پنومولیسین; Streptococcus Pneumoniae; Pneumolysin; Shikonin; Virulence; Genotoxicit; Lethal pneumonia;
Keywords: پنومولیسین; Organ of Corti; Hair cells; Ototoxicity; Streptococcus pneumoniae; Pneumolysin;
Keywords: پنومولیسین; Meningitis; climate; Neisseria meningitidis; Streptococcus pneumoniae; pollution; dust; A600; Absorbance at 600Â nm; CFU; Colony-forming units; OPKA; Opsonophagocytic killing assay; PLY; Pneumolysin;
Keywords: پنومولیسین; Streptococcus pneumoniae; Nasopharyngeal carriage; Pneumolysin; Pneumococcal histidine triad protein D; Vaccine efficacy; Infant; AE; adverse event; ATP; according-to-protocol; CI; confidence interval; dPly; pneumolysin toxoid; ELISA; enzyme-linked immuno
Keywords: پنومولیسین; Apigenin; Pneumolysin; Molecular dynamics simulation; Binding free energy;
Keywords: پنومولیسین; Adhesins; Hydrogen peroxide; Platelets; Platelet-activating factor; Pneumococcus; Pneumolysin; Streptococcus pneumoniae; Thrombocytopenia; Thrombocytosis; Toll-like receptors;
Keywords: پنومولیسین; Pneumolysin; Cholesterol-dependent cytolysin; Cellular recognition; Molecular docking; X-ray structure;
Keywords: پنومولیسین; AEC; primary human airway epithelial cells; ALG-2; apoptosis-linked gene 2; ALIX; ALG-2 interacting protein X; BCA; bicinchoninic acid; CCD; charge-coupled device; CDC; cholesterol-dependent cytolysins; Chmp4B; charged multivesicular body protein 4B; ESCR
Keywords: پنومولیسین; Influenza virus; Streptococcus pneumoniae; Pneumolysin; Respiratory tract co-infection; Immunopathology; Alveolar macrophages; Inflammatory monocytes; Arginase I; iNOS; Protection;
Systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant Plym2
Keywords: پنومولیسین; Detoxified pneumolysin; Plym2; Pneumolysin; Bacterium-like particles (BLP); S. pneumoniae; Intranasal vaccine;
Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro
Keywords: پنومولیسین; Calcium; Platelet-activating factor; Pneumolysin; P-selectin (CD62P); Severe pneumococcal disease;
The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation
Keywords: پنومولیسین; SecA2; Streptococcus pneumoniae; Pneumolysin; Export; O-glycosidase; Biofilms;
Pneumolysin induces cellular senescence by increasing ROS production and activation of MAPK/NF-κB signal pathway in glial cells
Keywords: پنومولیسین; Pneumolysin; Cellular senescence; Glial cells; ROS; MAPK; NF-κB;
Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells
Keywords: پنومولیسین; Osteoblast; Pneumolysin; Autophagy; Sp1; ROS; AMPK; mTOR;
Apigenin protects mice from pneumococcal pneumonia by inhibiting the cytolytic activity of pneumolysin
Keywords: پنومولیسین; Streptococcus pneumoniae; Pneumolysin; Anti-virulence; Apigenin;
Nitric oxide participates in the toxicity of Bacillus thuringiensis Cry1Ab toxin to kill Manduca sexta larvae
Keywords: پنومولیسین; NO; nitric oxide; NOS; nitric oxide synthase; Bt; Bacillus thuringiensis; l-NAME; L-NG-nitroarginine methyl ester; SNP; sodium nitroprusside; LC50; 50% lethal concentration; DENV; dengue virus; MAPK; mitogen activated protein kinase; VVC; Vibrio vulnificu
Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization
Keywords: پنومولیسین; Surface display; Autotransporter Hbp; Intranasal vaccine; Salmonella outer membrane vesicles (OMV); Streptococcus pneumoniae colonization; aa; amino acid; AT; autotransporter; CFU; colony forming units; Hbp; Hemoglobin protease; i.n.; intranasal; OM; oute
Ca2Â +-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins
Keywords: پنومولیسین; PLY; pneumolysin; SLO; streptolysin O; TLR; toll-like receptor; PKC; protein kinase C α; HEK; human embryonic kidney 293; CCh; carbachol; AEC; airway epithelial cells; HBE; human bronchial epithelial 16HBE14o-; Anx; annexin; Plasma membrane; Calcium; Ann
Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model
Keywords: پنومولیسین; Streptococcus pneumoniae; Pneumolysin; Pneumococcal histidine triad D protein; Pneumococcal choline binding protein A; Infant vaccination;
Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: A phase I/II randomized clinical study
Keywords: پنومولیسین; 23PPV; 23-valent pneumococcal polysaccharide vaccine; AE; adverse event; anti-PD; NTHi protein D antibody; ATP; according to protocol; dPly; pneumolysin toxoid; ELISA; enzyme-linked immunosorbent assay; GMC; geometric mean concentration; GMT; geometric me
Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial
Keywords: پنومولیسین; Pneumococcal proteins; dPly; PhtD; Safety; Immunogenicity; Toddler vaccination; AE; adverse event; anti-PD; NTHi protein D antibody; ATP; according-to-protocol; CI; confidence interval; dPly; pneumolysin toxoid; ELISA; enzyme-linked immunosorbent assay; G
A fluorescent multiplexed bead-based immunoassay (FMIA) for quantitation of IgG against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis protein antigens
Keywords: پنومولیسین; AOM; acute otitis media; CAP; community-acquired pneumonia; CbpA; choline binding protein A; CV; coefficient of variation; EDC; 1-ethyl-3 (3-dimethylamino-propyl) carbodiimide-HCl; FMIA; fluorescent multiplexed bead-based immunoassay; MFI; Mean Fluorescen
ReviewReview: Current and new generation pneumococcal vaccines
Keywords: پنومولیسین; Pneumococcal conjugate vaccines; Pneumococcal polysaccharide vaccines; Pneumococcal choline binding protein A; Pneumococcal surface protein A; Pneumococcal surface protein C; Pneumolysin; Polyhistidine triad proteins; Recombinant protein vaccines; Strepto
Intercellular communication via the endo-lysosomal system: Translocation of granzymes through membrane barriers
Keywords: پنومولیسین; CL; Cytotoxic lymphocyte; NK; natural killer cell; CTL; cytolytic T lymphocyte; LAMP; lysosomal associated membrane protein; ER; endoplasmic reticulum; GAG; glycosaminoglycan; SNARE; n-ethylmaleimide-sensitive factor attachment protein receptor; GrB; Gran
A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae
Keywords: پنومولیسین; Streptococcus pneumoniae; Pneumonia; PhtD; Pneumolysin; Rhesus macaque; Vaccine;
Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4
Keywords: پنومولیسین; Chemokine; Streptococcus pneumoniae; Pneumolysin; CXCL8; Toll-like receptor 4;
Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae
Keywords: پنومولیسین; Mucosal adjuvant; Pneumolysin; Non-toxic;
Effect of recurrent invasive pneumococcal disease on serum anti-pneumolysin IgG titres in HIV infected adults
Keywords: پنومولیسین; HIV infection; Pneumococcal bacteraemia; Pneumolysin;
Is quantitative PCR for the pneumolysin (ply) gene useful for detection of pneumococcal lower respiratory tract infection?
Keywords: پنومولیسین; Bronchoalveolar lavage; PCR; pneumolysin; pneumonia; Streptococcus pneumoniae
Feasibility of real-time polymerase chain reaction in whole blood to identify Streptococcus pneumoniae in patients with community-acquired pneumonia
Keywords: پنومولیسین; Real-time PCR; Whole blood; S. pneumoniae; Autolysin; Pneumolysin
Oligomerisation of pneumolysin on cholesterol crystals: Similarities to the behaviour of polyene antibiotics
Keywords: پنومولیسین; Pneumolysin; Cholesterol crystals; Pore-forming toxin; Arc-shaped oligomers
Pneumolysin generates multiple conductance pores in the membrane of nucleated cells
Keywords: پنومولیسین; Pneumolysin; Patch–clamp; Pores; Conductance
Hyaluronidase augments pneumolysin-mediated injury to human ciliated epithelium
Keywords: پنومولیسین; Ciliary beat frequency; Human ciliated epithelium; Hyaluronidase; Pneumolysin; Structural integrity
Oriented immobilisation of anti-pneumolysin Fab through a histidine tag for electrochemical immunosensors
Keywords: پنومولیسین; Electrochemical immunosensor; Gold film; Histidine tag; Fab fragment; Pneumolysin
Streptococcus pneumoniae: The role of apoptosis in host defense and pathogenesis
Keywords: پنومولیسین; Streptococcus pneumoniae; Apoptosis; Pneumolysin; Pneumococcal cell wall; Disease
Detection of pneumolysin in human urine using an immunosensor on screen-printed carbon electrodes
Keywords: پنومولیسین; Immunosensor; Alkaline phosphatase; 3-Indoxyl phosphate; Screen-printed carbon electrode; Streptavidin–biotin reaction; Pneumolysin
Limited protection of TAT-Bcl-XL against pneumolysin-induced neuronal cell death
Keywords: پنومولیسین; Streptococcus pneumoniae; Pneumolysin; Bcl-XL; TAT; SH-SY5Y; Neuroprotection;
Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination
Keywords: پنومولیسین; Microglia; Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 9; TNF-α; Nitric oxide; Pneumolysin;