دانلود مقالات ISI درباره Presenilin-1 + ترجمه فارسی

دارچین، چشم انداز امیدوار کننده به بیماری آلزایمر

Cinnamon, a promising prospect towards Alzheimer's disease

Keywords: AD; Alzheimer's disease; PPs; polyphenols; EGCG; epigallocatechin gallate; NFTs; neurofibrillary tangles; ACh; acetylcholine; Aβ; amyloid-beta; APP; amyloid precursor protein; PS-1; presenilin-1; PS-2; presenilin-2; AChE; acetylcholine esterase; Cdk5;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

داروهای دقیق برای بیماری آلزایمر

Precision pharmacology for Alzheimer's disease

Keywords: Aβ1-42; 42-amino acid-long Aβ peptide; AD; Alzheimer's disease; ADAPT; Alzheimer's Disease Anti-Inflammatory Prevention Trial; ADAS-Cog; Alzheimer's Disease Assessment Scale-Cognitive Subscale; ADCS-ADL; Alzheimer's Disease Cooperative Study Activ

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

بررسی سیستماتیک بیماری آلزایمر خانوادگی: تفاوت در ارائه ویژگی های بالینی در میان سه ژن جهش یافته و تفاوت های قومی بالقوه

A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences

Keywords: amyloid precursor protein; autosomal dominant; familial Alzheimer's disease; presenilin-1; presenilin-2

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

تغییرات لیپید غشایی و اثرات درمانی که به وسیله اسید هیدروکسی سدوکاواگزازنیک روی بیماری آلزایمر تأثیر می گذارد

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; PS1; presenilin-1; Aβ; amyloid-β peptide; GFP; green fluorescent protein; WT; wild type; LC/MS; liquid chromatography/mass spectrometry; PC; phosphatidylcholine; PE; phosphatidylethanolamine; PS;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

سولفید هیدروژن پیشرفت بیماری آلزایمر تجربی را با هدف قرار دادن مکانیسم های مختلف پاتوفیزیولوژیک کاهش می دهد

Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms

Keywords: Aβ; amyloid β; AD; Alzheimer's disease; APP; amyloid precursor protein; ERK1/2; extracellular signal-regulated kinases; H2S; hydrogen sulfide; JNK; c-jun N-terminal kinases; MAPK; mitogen-activated protein kinases; MDA; malondialdehyde; NaHS; sodium h

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Chronic benzodiazepine suppresses translocator protein and elevates amyloid β in mice

Keywords: AD; Alzheimer's disease; Aβ; amyloid β; cBZD; chronic benzodiazepine; MMS; mitochondrial membrane swelling; TSPO; translocator protein; PS1; presenilin-1; ROS; reactive O2 species;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Functional significance of O-GlcNAc modification in regulating neuronal properties

Keywords: PTM; post-translational modification; OGT; O-GlcNAc transferase; OGA; O-GlcNAcase; O-GlcNAc; O-linked β-N-acetylglucosamine; UDP-GlcNAc; uridine diphosphate N-acetylglucosamine; GalNAc; N-acetylgalactosamine; Gal; galactose; PSD; postsynaptic density; NF

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway

Keywords: Dioscin; Hepatocyte proliferation; γ-secretase; Liver regeneration; Notch1/Jagged1 signal pathway; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BrdU; 5-bromo-2-deoxy-uridine; CDK2; cyclin D-cyclin dependent kinase 2; CDK4; cyclin D-cyc

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function

Keywords: βGal; β-Galactosidase; Aβ; amyloid-β; Abl; Abelson murine leukemia viral oncogene homolog; AD; Alzheimer's disease; AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; BLA; basolateral amygdala; CaMKI

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology

Keywords: Aβ; Amyloid β-peptide; Ac; acetyl; AD; Alzheimer's disease; APP; Amyloid precursor protein; RAW264.7; Murine macrophage cells; Bel-7402; Human Hepatocellular Carcinoma cell line; BMSCs; Bone marrow stromal cells; ChAT; Choline acetyltransferase; DPPH;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10

Keywords: Aβ; amyloid-beta peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; CoQ10; Coenzyme Q10; DCF; 2′,7′-dichlorofluorescein; DIC; differential interference contrast; H2DCFDA; 2′-7′-dichlorofluorescin diacetate; HBSS; Hank's Balanced Sa

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Rebamipide reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells

Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; ASPD; amylospheroids; BCA; bicinchoninic acid; BACE1; β-site APP-cleaving enzyme-1; BDNF; brain-derived neurotrophic factor; BSA; bov

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Featured ArticleCharacterizing familial corticobasal syndrome due to Alzheimer's disease pathology and PSEN1 mutations

Keywords: Alzheimer's disease; Corticobasal degeneration; Presenilin-1; Volumetric MRI; SPECT;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells

Keywords: AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; APP; amyloid precursor protein; ATG; autophagy-related gene; AVs; autophagic vacuoles; Aβ; β-amyloid peptide; DPA; dehydropachymic acid; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GSK-3; Gl

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition

Keywords: Presenilin-1; γ-Secretase activity; SNAI1; Chemoresistance; E-cadherin; EMT;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin

Keywords: Accreta; Trophoblast; Myometrium; Invasion; E-cadherin; Presenilin-1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Ischemic conditions and β-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells

Keywords: CNS; central nervous system; AD; Alzheimer's disease; RBE4; rat brain endothelial cell line; OGD; oxygen and glucose deprivation; ogR; oxygen and glucose Restoration; BACE1; amyloid precursor protein (APP) β-secretase; PSEN1; presenilin-1; Aβ; amyloid p

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway

Keywords: ATG4d; autophagy-related gene 4d; ATG6; autophagy-related gene 6; ATG12; autophagy-related gene 12; BAX; BCL-2 Associated X Protein; BCL-2; B-cell lymphoma-2; BW; body weight; Bet; piglets born to sows supplemented with betaine diets; CCND2; cyclin D2; Co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1

Keywords: PS1; presenilin 1; APP; amyloid precursor protein; AD; Alzheimer's disease; NTF; N-terminal Fragment; CTF; C-terminal Fragment; TM; transmembrane domain; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPE; 1-palmitoyl-2-oleoyl-sn-glycero-3-pho

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Research ReportOpposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo

Keywords: Alzheimer׳s disease; Dopamine; BDNF; Amyloid protein precursor; Presenilin-1; Transgenic mice;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Methods to monitor monocytes-mediated amyloid-beta uptake and phagocytosis in the context of adjuvanted immunotherapies

Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; APP; amyloid precursor protein; AS01B; adjuvant system 01B; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle medium; DPBS; Dulbecco's Phosphate Buffered Saline; EOAD; early-onset AD; Fig.; figure; FMOs

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Clinical and molecular studies reveal a PSEN1 mutation (L153V) in a Peruvian family with early-onset Alzheimer's disease

Keywords: Presenilin-1; Peruvian; Early-onset Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; BBB; blood-brain barrier; BSA; bovine serum albumin; GSK-3β; glycogen synthase kinase-3β; GST; glutathione S-transferase; ICV; intracerebroventricularly; NFTs; neurofibrillary tangles; Nrf2; nuclear factor-E

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation

Keywords: SP-B; Surfactant protein B; SP-C; Surfactant protein C; NRG-1; Neuregulin-1; TACE; Tumor necrosis factor alpha converting enzyme; DSPC; Disaturated phosphatidyl choline; ErbB receptor; Gamma secretase; Presenilin-1; Neonatal lung; Type II cell; Surfactant

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Decisive role of Reelin signaling during early stages of Alzheimer's disease

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; AON; anterior olfactory nucleus; ApoER2; apolipoprotein E receptor 2; APP; amyloid precursor protein; Dab-1; Disabled-1; GWA; genome-wide association; LTP; long term potentiation; MCI; mild cognitive impairmen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes

Keywords: Alzheimer's disease; Fatty acids; Calcium; STAT3; BACE1; Presenilin-1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Tau protein kinases: Involvement in Alzheimer's disease

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Arg; Abl-related gene; SFK; Src family kinase; Aβ; β-amyloid; BBB; blood brain barrier; LD50; lethal dose 50; c-Abl; c-Abelson; Cables; c-Abl-binding adaptator protein; CaMKII; Ca2+/calmodulin-dep

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: A proteomics study

Keywords: AD; Alzheimer's disease; MCI; mild cognitive impairment; Aβ; amyloid β-peptide; FAD; familial Alzheimer's disease; NFT; intracellular neurofibrillary tangles; APP; amyloid precursor protein; PS-1; presenilin-1; PS-2; presenilin-2; AO; antisense oligonuc

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2013 سفارش ترجمه

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Keywords: AD; Alzheimer's disease; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor; aPKC; atypical protein kinase C; APP; amyloid-β precursor protein; ATG; AuTophaGy-related; BDNF; brain-derived neurotrophic factor; C/EBP; C

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

Keywords: acyl-SG; S-acyl glutathione; AD; Alzheimer disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BODIPY; 4,4-difluoro-3a,4a-diaza-s-indacene; ChAT; choline acetyltransferase; CM-H2DCFDA; 2′,7′-dichlorodihydrofluorescein diacetate, acetyl e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

Keywords: Stem cells; Amyloid; Presenilin-1; Brain

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh × PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

Keywords: Oxidative stress; Amyloid β-peptide; Alzheimer's disease; Presenilin-1; Redox proteomics; Protein carbonyls

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Transient activation of Notch signaling in the injured adult brain

Keywords: Notch1; Hes1; Presenilin-1; Cryo-injury; BrdU; CNS

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein

Keywords: AD; Alzheimer disease; APP; amyloid precursor protein; DRM; detergent-resistant membrane subdomain; LRP; low-density lipoprotein receptor-related protein; PS-1; presenilin-1; ROS; reactive oxygen species; TMA-DPH; 1-(4-trimethylammoniumphenyl)-6-phenyl-1,

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

A novel behavioral paradigm for assessing the concept of nests in mice

Keywords: Nest; Concept; NMDA receptor; Presenilin-1; Knockout; Cre/loxP; Forebrain

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Muscarinic activation attenuates abnormal processing of β-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells

Keywords: β-Amyloid peptide; β-Amyloid precursor protein; β-Site APP-cleaving enzyme 1; Presenilin-1; Retinal ganglion cells; Hypoxia

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

A new and simple approach for genotyping Alzheimer's disease presenilin-1 mutant knock-in mice

Keywords: Presenilin-1; Genotyping; SSCP; Knock-in; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice

Keywords: Alzheimer's disease; Presenilin-1; Acetylcholinesterase; Cholinergic innervation; Aβ peptide; Transgenic mouse

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Sodium selenite inhibits γ-secretase activity through activation of ERK

Keywords: Alzheimer's disease; Amyloid-β; MEK1; Nicastrin; Presenilin-1; C99; Phosphorylation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

Keywords: Calcium; Mouse; Gamma secretase; Neurodegenerative disease; Ion channel gating; Presenilin-1; Alzheimer's disease; Sporadic AD; Familial AD; FAD; FTD

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

The R269H mutation in presenilin-1 presenting as late-onset autosomal dominant Alzheimer's disease

Keywords: Alzheimer's disease; Genetics; Presenilin-1; R269H

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population

Keywords: Presenilin-1; E318G mutation; Familial Alzheimer's Disease; Genetics; Amyloid beta-protein; Neurodegenerative disease; Skin biopsy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its β-catenin-binding region

Keywords: Presenilin-1; β-Catenin; D257A; Endothelial progenitor cells; OP9 cells; Flk-1; E-cadherin;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Chinese Presenilin-1 V97L mutation enhanced Aβ42 levels in SH-SY5Y neuroblastoma cells

Keywords: Familial Alzheimer's disease; Presenilin-1; Mutation; SH-SY5Y; β-Amyloid peptide

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Presenilin-1 is an unprimed glycogen synthase kinase-3β substrate

Keywords: PS-1, presenilin-1; NTF, N-terminal fragment; CTF, C-terminal fragment; APP, β-amyloid precursor protein; GSK-3β, glycogen synthase kinase-3βAlzheimer’s disease; Glycogen synthase kinase 3β; Presenilin-1; Phosphorylation; Gamma-secretase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Differences in regional brain atrophy in genetic forms of Alzheimer's disease

Keywords: Alzheimer's disease; Atrophy; Genetic mutations; Presenilin-1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation

Keywords: Presenilin-1; Nicastrin; Skeletal muscle; Denervation; Myonucleus

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Enhanced accumulation of tau in doubly transgenic mice expressing mutant βAPP and presenilin-1

Keywords: Alzheimer's disease; Doubly transgenic mouse; Presenilin-1; Tau; Aβ; Tg2576;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42

Keywords: Alzheimer's disease; Beta amyloid-protein; Presenilin-1; Age of onset; Pathogenesis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه

Aberrant accentuation of neurofibrillary degeneration in the hippocampus of Alzheimer's disease with amyloid precursor protein 717 and presenilin-1 gene mutations

Keywords: Alzheimer's disease; Amyloid precursor protein; Apolipoprotein; Neurofibrillary tangles; Presenilin-1;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه