Keywords: گیرنده پروتئاز فعال; ADP; adenosine diphosphate; APC; activated protein C; AT-III; antithrombin III; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CLP; cecal ligation - perforation; DIC; disseminated intravascular coagulation; LPS; lipopolysaccharide; IL-
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Keywords: گیرنده پروتئاز فعال; ATII; alveolar epithelial type II; AIIt; annexin A2 heterotetramer; APC; activated protein C; BALF; broncho-alveolar lavage fluid; DAD; diffuse alveolar damage; EGF; epidermal growth factor; ECM; extracellular matrix; FAK; focal adhesion kinase; FV; facto
Keywords: گیرنده پروتئاز فعال; Fungi; innate immunity; adaptive immunity; airway; ABPM; Allergic bronchopulmonary mycosis; AFRS; Allergic fungal rhinosinusitis; AHR; Airway hyperreactivity; CLR; C-type lectin receptor; CRS; Chronic rhinosinusitis; DC; Dendritic cell; DC-SIGN; Dendritic
Keywords: گیرنده پروتئاز فعال; AA; arachidonic acid; ADP; adenosine diphosphate; CALR; calreticulin; ET; essential thrombocythemia; HRPR; high on-treatment residual platelet reactivity; JAK; janus kinase; MEA; multiple electrode aggregometry; MPL; myeloproliferative leukemia virus onco
Keywords: گیرنده پروتئاز فعال; AD; atopic dermatitis; CCL; chemokine (C-C motif) ligand; CXCL; chemokine (C-X-C motif) ligand; CXCR; chemokine (C-X-C motif) receptor; DEG; differentially expressed gene; FC; fold changes; KLK; kallikrein; MRGPR; Mas-related G-protein coupled receptor; N
Keywords: گیرنده پروتئاز فعال; BMP; bone morphogenetic protein; CTGF; connective tissue growth factor; ECM; extracellular matrix; EMT; epithelial-mesenchymal transformation; Glut1; glucose transporter 1; GPCR; G protein-coupled receptor; KS; Kaposi's sarcoma; LATS; large tumor suppress
Keywords: گیرنده پروتئاز فعال; LAMP; lysosomal-associated membrane protein; PAR; protease-activated receptor; PBS; phosphate buffered saline; siRNA; small interfering RNA;
Keywords: گیرنده پروتئاز فعال; DAPI; 4â²,6-diamidino-2-phenylindole; DN; double negative; FSC-A; forward-scattered light area; FSC-H; forward-scattered light height; Lck-Cre::F2rl1w/w; Lck-Cre positive wildtype mice; F2rl1fl/fl; Lck-Cre negative PAR2 floxed mice; Lck-Cre::F2rl1fl/fl;
Keywords: گیرنده پروتئاز فعال; Itch; Sensory nerves; Pruritogens; Protease-activated receptor; Endothelin-1; Signal transduction; Neuropeptide receptor; Translational medicine;
Keywords: گیرنده پروتئاز فعال; TIA; transient ischemic attack; RCT; randomized controlled trials; MI; myocardial infarction; DAPT; dual antiplatelet therapy; PAR; protease-activated receptor; DDIs; drug-drug interactions; PD; pharmacodynamics; PK; pharmacokinetics; TX; thromboxane; AA;
Keywords: گیرنده پروتئاز فعال; AAR; area at risk; AP; agonist peptide; Cat.G; cathepsin G; cTnI; cardiac troponin I; EGFR; epidermal growth factor receptor; IA; infarct area; IR; ischemia-reperfusion; KO; knockout; LAD; left anterior descending; LV; left ventricular; MPO; myeloperoxi
Keywords: گیرنده پروتئاز فعال; Kallikrein-related peptidase; KLK; Cancer; Function; Protease; Carcinogenesis; AR; androgen receptor; B2R; kinin receptor B2; BMP; bone morphogenic protein; CDH; cadherin; DHT; dihydrotestosterone; DNA; deoxyribonucleic Acid; Dsg; desmoglein; ECM; extrace
Keywords: گیرنده پروتئاز فعال; ACC/AHA; American College of Cardiology/American Heart Association; ACS; acute coronary syndrome; ADP; adenosine diphosphate; AF; atrial fibrillation; BRIGHT; Bivalirudin in Acute Myocardial Infarction vs Heparin and GPI Plus Heparin Trial; CAD; coronary
Keywords: گیرنده پروتئاز فعال; ASM; airway smooth muscle; AHR; airway hyperresponsiveness; β2AR; beta 2 adrenergic receptor; BTR; bitter taste receptor; CysLT1R; cysteinyl leukotriene receptor 1; CaSR; calcium sensing receptor; EP; prostanoid EP receptor; GPCR; G protein-coupled recep
Keywords: گیرنده پروتئاز فعال; Thrombin; Protease-activated receptor; Hippocampus; Pilocarpine; Epileptogenesis; Status epilepticus
Keywords: گیرنده پروتئاز فعال; Protease-activated receptor; Gingiva; Chronic periodontitis; Immunohistochemistry; Reverse transcriptase polymerase chain reaction
Keywords: گیرنده پروتئاز فعال; Protease-activated receptor-2; Serine protease; Cancer; G protein-coupled receptor; Angiogenesis; PAR; Protease-activated receptor; PLC; phospholipase C; PKC; protein kinase C; MAPK; mitogen-activated kinase; TF-FVIIa; tissue factor and factor VIIa; EGFR;
Keywords: گیرنده پروتئاز فعال; Asthma; epithelium; dendritic cells; TH2; AAM; Alternatively activated macrophage; BEC; Bronchial epithelial cell; cDC; Conventional dendritic cell; DC; Dendritic cell; FCP; Fibrinogen cleavage product; HDM; House dust mite; HM-GB1; High-mobility group bo
Keywords: گیرنده پروتئاز فعال; ADP; adenosine 5â²-diphosphate; AA; arachidonic acid; CLA; conjugated linoleic acid; COX-1; cyclooxygenase-1; CVD; cardiovascular disease; DHA; docosahexaenoic acid; EFSA; European Food Safety Authority; EPA; eicosapentaenoic acid; GP; glycoprotein; ICAM
Keywords: گیرنده پروتئاز فعال; ARC; arachidonate-regulated Ca2+ entry channels; BBB; blood-brain barrier; BCEC; bovine brain capillary endothelial cells; BK; bradykinin; CaM; calmodulin; CaMKII; Ca2+/calmodulin-dependent kinase II; cGMP; cyclic guanosine monophosphate; CRAC; Ca2+ rel
Evidence for functional PAR-4 thrombin receptor expression in cardiac fibroblasts and its regulation by high glucose
Keywords: گیرنده پروتئاز فعال; Thrombin; Protease-activated receptor; Cardiac; Fibroblast; Diabetes; High glucose;
Protease-activated receptor 2 (PAR2) upregulates granulocyte colony stimulating factor (G-CSF) expression in breast cancer cells
Keywords: گیرنده پروتئاز فعال; Protease-activated receptor; Granulocyte colony stimulating factor; Breast cancer; TCGA; ENMD-1068;
Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch
Keywords: گیرنده پروتئاز فعال; Mrgpr; mas-related G-protein coupled receptor; PAR; protease-activated receptor;
Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke
Keywords: گیرنده پروتئاز فعال; 5α-DHP; 5α-dihydroprogestrone; ABC; ATP-binding cassette; AF6; ALL-1-fused gene from chromosome 6; ALL; acute lymphoblastic leukemia; AMPAR; amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor; Ang-1; angiopoietin-1; AP-1; activator protein-1; BBB;
The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D
Keywords: گیرنده پروتئاز فعال; Allergy; asthma; Staphylococcus aureus; sensitization; serine protease; AECII; Airway epithelial cell type II; APC; Allophycocyanin; BALF; Bronchoalveolar lavage fluid; DC; Dendritic cells; DMEM; Dulbecco modified Eagle medium; FACS; Fluorescence-activate
Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells
Keywords: گیرنده پروتئاز فعال; Protease-Activated Receptor; PAR1; PAR2; GPCR; Calcium mobilization; Parmodulin; ML161; Vorapaxar; RWJ-58259; Negative allosteric modulator;
Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node
Keywords: گیرنده پروتئاز فعال; Atrial fibrillation; Factor Xa; Late sodium current; Pulmonary vein; Protease-activated receptor;
Factor Xa inhibition by rivaroxaban regulates fibrogenesis in human atrial fibroblasts with modulation of nitric oxide synthesis and calcium homeostasis
Keywords: گیرنده پروتئاز فعال; Fibroblasts; Fibrosis; Rivaroxaban; Protease-activated receptor; Atrial fibrillation; Stroke;
The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction
Keywords: گیرنده پروتئاز فعال; Cardiac remodeling; Coagulation; Factor Xa; Myocardial infarction; Protease-activated receptor; Rivaroxaban;
Differential regulation of IL-23 production in M1 macrophages by TIR8/SIGIRR through TLR4- or TLR7/8-mediated signaling
Keywords: گیرنده پروتئاز فعال; Granulocyte-macrophage colony-stimulating factor; IL-12p40; IL-23; Interferon regulatory factor 5; Single immunoglobulin interleukin-1 receptor-related molecule; ELISA; enzyme-linked immunosorbent assay; GMâCSF; granulocytemacrophage colony-stimulatin
Full Length ArticleDirect thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice
Keywords: گیرنده پروتئاز فعال; Cardiac fibrosis; Direct thrombin inhibitor; Protease-activated receptor; Thrombin;
Differential roles of kallikrein-related peptidase 6 in malignant transformation and ÎNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma
Keywords: گیرنده پروتئاز فعال; Oral cancer; Kallikrein-related peptidase 6; Malignant transformation; Epithelial-to-mesenchymal transition (EMT); ÎNp63; Oral squamous cell carcinoma (OSCC); Protease-activated receptor; Metastasis; Prognosis; DMEM; dulbecco's modified Eagle medium; E
Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro
Keywords: گیرنده پروتئاز فعال; AD; Alzheimer's disease; AP; activating peptide; BBB; blood-brain barrier; BMEC; brain microvascular endothelial cell; DMEM; Dulbecco's modified Eagle's medium; EDTA; ethylenediaminetetraacetic acid; ERK; extracellular signal-regulated kinase; FBS
Antiplatelet Agents for the Treatment and Prevention of Coronary Atherothrombosis
Keywords: گیرنده پروتئاز فعال; aspirin; cangrelor; clopidogrel; prasugrel; ticagrelor; vorapaxar; ACS; acute coronary syndromes; CABG; coronary artery bypass graft; CAD; coronary artery disease; COX; cyclooxygenase; DAPT; dual antiplatelet therapy; ICH; intracranial hemorrhage; MI; myo
Original ArticleImmunology/InfectionInvolvement of TRPV4 in Serotonin-Evoked Scratching
Keywords: گیرنده پروتئاز فعال; DRG; dorsal root ganglion; 5-HT; 5-hydroxytryptamine (serotonin); Mrgpr; Mas-related G-protein-coupled receptor; PAR; protease-activated receptor; TRP; transient receptor potential; TRPV1; transient receptor potential vanilloid type-1; TRPV4; transient
Complement MASP-1 enhances adhesion between endothelial cells and neutrophils by up-regulating Eâselectin expression
Keywords: گیرنده پروتئاز فعال; HUVEC; human umbilical vein endothelial cell; MBL; mannan-binding lectin; MASP; mannan-binding lectin-associated serine protease; PAR; protease-activated receptor; Adhesion; Complement; Endothelial cell; Neutrophil; Inflammation; MASP-1;
Inhibition of coagulation proteases Xa and IIa decreases ischemia-reperfusion injuries in a preclinical renal transplantation model
Keywords: گیرنده پروتئاز فعال; α-SMA; α-smooth muscle actin; DCD; donors deceased after cardiac death; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HAEC; human aortic endothelial cell; HES; hematoxylin-eosin-s
Protease-activated receptor 1 and 2 contribute to angiotensin II-induced activation of adventitial fibroblasts from rat aorta
Keywords: گیرنده پروتئاز فعال; Protease-activated receptor; Angiotensin II; Adventitial fibroblast; Adventitial remodeling;
Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion
Keywords: گیرنده پروتئاز فعال; Cysteine protease; Papain; Basophil; IL-3; CD123; Ab; antibody; BMB; bone marrow-derived basophil; IL-3R; IL-3 receptor; LC-MS; liquid chromatography-mass spectrometry; MFI; mean fluorescence intensity; PAR; protease-activated receptor; rIL-3; recombinant
Clinical implication of protease-activated receptor-2 in idiopathic pulmonary fibrosis
Keywords: گیرنده پروتئاز فعال; Honeycombing; Idiopathic pulmonary fibrosis; Mortality; Protease-activated receptor
Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines
Keywords: گیرنده پروتئاز فعال; Glioblastoma; Protease-activated receptor; Mitogen-activated protein kinase; Vascular endothelial growth factor; Angiogenesis;
Cross-sensitization of histamine-independent itch in mouse primary sensory neurons
Keywords: گیرنده پروتئاز فعال; 5-HT; 5-hydroxytrmptamine; AITC; allyl isothiocyanate; ANOVA; analysis of variance; BAM8-22; bovine adrenal medulla peptide 8-22; CQ; chloroquine; DRG; dorsal root ganglion; Mrgpr; Mas-related G protein-coupled receptor; PAR; protease-activated receptor;
High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2
Keywords: گیرنده پروتئاز فعال; Mast cell; Stem cell factor; Protease-activated receptor; Renal cell carcinoma; Hemodialysis
Protease-activated receptor 1 (PAR1) coupling to Gq/11 but not to Gi/o or G12/13 is mediated by discrete amino acids within the receptor second intracellular loop
Keywords: گیرنده پروتئاز فعال; BBB; blood-brain barrier; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; ECL; enhanced chemiluminescence; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptor; GRK2; G protein-coupled receptor kinase-2; InsP
The role of dendritic cells in asthma
Keywords: گیرنده پروتئاز فعال; Dendritic cells; asthma; allergen; TH2 inflammation; BALF; Bronchoalveolar lavage fluid; BDCA; Blood dendritic cell antigen; cDC; Conventional dendritic cell; DC; Dendritic cell; HDM; House dust mite; IDO; Indoleamine 2,3-dioxygenase; ILT7; Immunoglobulin
Proteases involved in cartilage matrix degradation in osteoarthritis
Keywords: گیرنده پروتئاز فعال; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; APC; activated protein C; CITED2; cAMP-responsive element-binding protein/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2; ECM; extracellular matrix; ERK;
Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity
Keywords: گیرنده پروتئاز فعال; Chemokines; basophils; chemotaxis; TH2; allergens; APC; Antigen-presenting cell; BM; Bone marrow; BMB; Bone marrow-derived basophil; DC; Dendritic cell; FITC; Fluorescein isothiocyanate; Jak; Janus kinase; LN; Lymph node; MC; Mast cell; OVA; Ovalbumin;
Decreased expression of protease-activated receptor 4 in human gastric cancer
Keywords: گیرنده پروتئاز فعال; Protease-activated receptor; Gastric cancer; Real-time PCR; Immunohistochemistry; Methylation;
Conformationally restricted analogs of the direct thrombin inhibitor FM 19
Keywords: گیرنده پروتئاز فعال; DTI; direct thrombin inhibitor; HOBt; hydroxybenzotriazole; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uroniumhexafluorophosphate; DIEA; N,N-diisopropylethylamine; Oic; (2S,3aS,7aS)-octahydroindole-2-carboxylic acid; Phe(p-Me); p-methyl phenylalanine
Activity of Protease-Activated Receptors in the Human Submucous Plexus
Keywords: گیرنده پروتئاز فعال; Enteric Nervous System; Irritable Bowel Syndrome; Inflammatory Bowel Disease; Mucosal Secretion; AP; activating peptide; [Ca]i; intracellular Ca2+ concentration; PAR; protease-activated receptor; RP; reversed peptide; T/G/N; tissue/ganglia/neurons; TTX; t