Cross-sensitization of histamine-independent itch in mouse primary sensory neurons

► MrgprC11 agonist BAM8-22 cross-sensitized scratching evoked by PAR-2 agonist. ► MrgprA3 agonist chloroquine cross-sensitized BAM8-22-evoked scratching. ► Histamine cross-sensitized chloroquine- and BAM8-22-evoked scratching. ► PAR-2 agonist cross-sensitized chloroquine-evoked scratching and DRG cell responses. ► PAR-2 is a peripheral target to reduce sensitization associated with chronic itch.