Appraisal of sildenafil binding on the structure and promiscuous esterase activity of native and histidine-modified forms of carbonic anhydrase II
Keywords: هیدروفوبیت سطح پروتئین; hCA; human carbonic anhydrase; PDE5; phosphodiesterase-5; CD; circular dichroism; PSH; protein surface hydrophobicity; ANS; 1,8-anilinonaphtalene sulfonate; PDB; protein data bank; ED; erectile dysfunction; CAIs; CA inhibitors; DEPC; diethyl pyrocarbonate