Keywords: Platelets; TCIPA; Breast cancer cells; P2Y12 receptor; Phospholipase C; Calcium signaling; Rap1;
مقالات ISI (ترجمه نشده)
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Keywords: ABCC8; ATP Binding Cassette Subfamily C Member 8; CAPN10; calpain 10; Cdkal1; Cdk5 regulatory associated protein 1-like 1; DM; diabetes mellitus; GLIS3; GLIS Family Zinc Finger 3; HMGA1; high mobility group A1; HNF1A; hepatocyte nuclear factor 1A; HNF1Î
Keywords: ACTB; actin-β; ACTG1; actin-γ1; ADA; American Diabetes Association; Ascl1; achaete-scute homolog 1; BMPR2; bone morphogenetic protein receptor type 2; CCNG2; cyclin G2; CNS; central nervous system; CRKL; CRK-like proto-oncogene adaptor protein; CSNK2A2;
Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis
Keywords: RA-GEF-2; Rap1; Small GTPases; Spermatogenesis; Male infertility;
Rap1 promotes proliferation and migration of vascular smooth muscle cell via the ERK pathway
Keywords: Vascular smooth muscle cell; Rap1; Rap1-GAP; Proliferation; Migration;
Comparative genomics and proteomic analyses between lethal and nonlethal strains of Plasmodium berghei
Keywords: Plasmodium; Comparative genomics; Proteomics; RAP1; RAP2/3;
Correlation between telomerase and mTOR pathway in cancer stem cells
Keywords: CSCs; cancer stem cells; mTOR; mammalian target of rapamycin; PI3K; phosphoinositide 3-kinase; AKT; serine/threonine kinase 1; hTERT; human telomerase reverse transcriptase; TERC; telomerase RNA component; GBM; glioblastoma multiforme; TRF1; telomeric rep
High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype
Keywords: TPP1; protein encoded by adrenocortical dysplasia gene; Acd; adrenocortical dysplasia gene; acd; adrenocortical dysplasia mutation; p53; transformation related protein 53; DNA; Deoxyribonucleic acid; DC; Dyskeratosis congenita; HHS; Hoyeraal-Hreidarsson s
MicroRNA-149 is associated with clinical outcome in human neuroblastoma and modulates cancer cell proliferation through Rap1 independent of MYCN amplification
Keywords: Neuroblastoma; miR-149; Overall survival; Rap1; Proliferation; Epigenetics;
Regulated expression of the lncRNA TERRA and its impact on telomere biology
Keywords: TERRA; telomere repeat-containing RNA; TRF1/2; telomeric repeat-binding factors 1 and 2; POT1; protection of telomeres 1; TIN2; TRF1-interacting nuclear factor 2; TPP1; adrenocortical dysplasia protein homologue (also called ACD, PTOP, PIP1 & TINT1); RAP1
Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression
Keywords: Rap1; Small GTPase; Rapgef2; Radial glial cells; Adherence junction; ERK; AJ; adherens junction; RGC; radial glial cell; ERK; extracellular signal-regulated kinase; GEF; guanine nucleotide exchange factor; cKO; conditional knockout; ECM; ectopic cortical
The axon guidance function of Rap1 small GTPase is independent of PlexA RasGAP activity in Drosophila
Keywords: Rap1; Plexin A; Semaphorin-1a; Ras1; RasGAP; Axon guidance;
The small GTPase Rap1 is a modulator of Hedgehog signaling
Keywords: Hedgehog; Signal transduction; Morphogenesis; GTPase; Rap1;
Epac activation sensitizes rat sensory neurons through activation of Ras
Keywords: Peripheral sensitization; Calcitonin gene-related peptide (CGRP); Excitability; Exchange proteins activated by cAMP (Epacs); Ras; Rap1; Sensory neurons;
ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity
Keywords: ZSCAN4; TRF1; Cancer; Telomeres; Telomerase; ALT pathway; ALT; alternative lengthening of telomeres; BIFC; bimolecular fluorescence complementation; Co-IP; co-immunoprecipitation; ESC; embryonic stem cells; GST; glutathione S-transferase; PinX1; PIN2/TERF
The structure and conformational switching of Rap1B
Keywords: G protein; Protein crystallography; Mutant; Conformation change; Rap1; GppNHp; guanosine 5â²[β,γ-imido]triphosphate;
PLCε mediated sustained signaling pathways
Keywords: G-protein coupled receptors (GPCRs); Phospholipase C-ε (PLCε); Phosphatidylinositol4,5-bisphosphate (PIP2); Inositol 1,4,5-trisphosphate (IP3); Diacylglycerol (DAG); Protein kinase D(PKD); RhoA; Rap1; Ras; Golgi;
Research ArticleChronic replicative stress induced by CCl4 in TRF1 knockout mice recapitulates the origin of large liver cell changes
Keywords: TRF1 and TRF2; Telomeric repeat binding factors 1 and 2; TIN2; tTRF1-interacting protein 2; POT1; Protection of telomeres 1; TPP1; POT1-TIN2 organizing protein; RAP1; Repressor activator protein 1; LLCC; Large liver cell changes; SLCC; Small liver cell ch
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members
Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z
Cdk5 regulates Rap1 activity
Keywords: Signal transduction; Cyclin-dependent kinase 5; Rap1; C3G; Neurones;
PRL-3 activates NF-κB signaling pathway by interacting with RAP1
Keywords: PRL-3; phosphatase of regenerating liver-3; RAP1; repressor/activator protein 1; PTP; protein tyrosine phosphatases; PRL-3; RAP1; NF-κB; Cancer;
Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP (Epac)
Keywords: Epac; Decidualization; IGF-binding protein-1; Rap1;
Human placental multipotent mesenchymal stromal cells modulate trophoblast migration via Rap1 activation
Keywords: Hepatocyte growth factor; Integrin β1; Placental multipotent mesenchymal stromal cells; Protein kinase A; Rap1;
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways
Keywords: Rolipram; PDE; Glioblastoma; cAMP; PKA; Epac1; Rap1;
Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response
Keywords: Rap1; ras; Raf1; CD3+; PMA; CD3/CD28; Inflammation; Cytokines;
Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis
Keywords: Autoimmunity; T lymphocyte; Tolerance; Experimental autoimmune encephalitis; Rap1;
Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages
Keywords: DHE; dihydroethidium; DMEM; Dulbecco's modified Eagle medium; Epac; exchange protein directly activated by cAMP; ERK; extracellular signal-regulated kinases; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; GAP; GTPase activating proteins; GDI;
Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila
Keywords: Rap1; DE-cadherin; Canoe; Thickvein; Ras; Wing vein;
C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity
Keywords: C3G; Platelet; Transgenic mice; Granulocyte; Neutrophil; Rap1
Solution structure of Rap1 BRCT domain from Saccharomyces cerevisiae reveals a novel fold
Keywords: NMR; Rap1; BRCT domain
Rap1 GTPases: An emerging role in the cardiovasculature
Keywords: Rap1; cAMP; Epac
Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt
Keywords: Statin; Toxicity; Mitochondrion; Akt; Rap1;
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control
Keywords: Endothelial barrier function; Adherens Junction; Rap1; Epac1; PDZ-GEF;
Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma
Keywords: Galanin; GALR2; Proliferation; Apoptosis; Rap1;
RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures
Keywords: Anterior commissure; Corpus callosum; Rap1; Guanine nucleotide exchange factor; Conditional knockout mice; Midline glia;
PKA and Epac synergistically inhibit smooth muscle cell proliferation
Keywords: Epac; PKA; Rap1; cAMP; Proliferation; Vascular smooth muscle cell;
Pamidronate inhibits antiapoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells
Keywords: Bcl-2; Pamidronate; Bisphosphonate; Prostate cancer; Mevalonate pathway; Rap1
BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion
Keywords: BAG, Bcl-2-associated athanogene; PDZGEF2, PDZ domain containing guanine nucleotide exchange factor 2Hsp70; Molecular chaperone; Rap1; Guanine nucleotide exchange factor; WW domain; Cell adhesion
RalGDS family members couple Ras to Ral signalling and that's not all
Keywords: RalGDS family; Guanine nucleotide exchange factor; Ras effectors; Ras family; Rap1; Ral
Rap1, a mercenary among the Ras-like GTPases
Keywords: Ras-like GTPases; Rap1; Morphogenesis; Cytoskeleton; Cell adhesion; Polarity; Genetics;
Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1
Keywords: Allantois; Angiogenesis; RA-GEF-1; Rap1; Vascular plexus; Yolk sac
Cell–cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors
Keywords: Rap1; Junction; Cell–cell contact; Barrier function; E-cadherin; Actin; C3G; PDZ-GEF; Epac1
Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: Involvement of Epac1 and PKA
Keywords: Rheumatoid arthritis; Inflammation; Prostaglandin E2; Rap1; Exchange protein directly activated by cAMP; Protein kinase A
GSK3β modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner
Keywords: PACAP; GSK3β; Rap1; Caveolae; PC12; Neurite outgrowth;
Regulation of Dictyostelium morphogenesis by RapGAP3
Keywords: Dictyostelium; Rap1; RapGAP; Morphogenesis; Cell adhesion;
Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila
Keywords: Rap1; Adhesion; Cadherin; Planar cell polarity; Canoe; Wing vein; Ommatidia
MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1
Keywords: Rap2; Rap1; Ras; Small G protein; MINK; TNIK; Mitogen-activated protein kinase kinase kinase kinase; TANC1; Postsynaptic scaffold protein
Expression of Babesia bovis rhoptry-associated protein 1 (RAP1) in Brucella abortus S19
Keywords: Brucella abortus S19; Babesia bovis; RAP1
The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions
Keywords: Rap1; PDZ-GEF2; Adherens junction; E-cadherin;
Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcγ-receptor-mediated phagocytosis in alveolar macrophages
Keywords: Phagocytosis; Prostaglandin E2; Exchange protein activated by cAMP; cAMP; Rap1; Microtubules; Immunofluorescence; Fcγ receptors