Keywords: Aβ; Beta-amyloid; AD; Alzheimer's disease; APPs; Secreted amyloid precursor protein; BDNF; Brain-derived neurotrophic factor; CNS; Central Nervous System; DS; Down syndrome; DSCAM; Down syndrome Cell Adhesion Molecule; DYRK1A; Dual-specificity Tyrosine P
مقالات ISI (ترجمه نشده)
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Keywords: AD; Alzheimer Disease; DS; Down Syndrome; Aβ; amyloid-β; HSA21; Chromosome 21; APP; Amyloid precursor protein; BACE1/2; β-site APP cleaving enzyme 1/2; βCTF; β carboxyl-terminal fragment; PSEN1; presenilin 1; APPL1; adaptor protein containing pleckst
Keywords: OS; oxidative stress; CNS; central nervous system; ROS; reactive oxygen species; SOD; superoxide dismutase; CAT; catalase; Cu; copper; Zn; zinc; Mn; manganese; Fe; iron; Ni; nickel; DA; dopamine; PHOX; NADPH oxidase; Nrf2; nuclear factor erythroid 2-relat
Keywords: DS; Down Syndrome; Cu/ZnSOD; Cu/Zn superoxide dismutase; MnSOD; Mn superoxide dismutase; GPx; glutathione peroxidase; TL; telomere length; ROS; reactive oxygen species; DHR; dihydrorhodamine; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Trx1; thioredo
Mitochondria as pharmacological targets in Down syndrome
Keywords: AD; Alzheimer's disease; AGO; Argonaute proteins; AMPK; AMP-activated protein kinase; ANTs; adenine nucleotide translocators; AK; adenylate kinase; APP; amyloid-β precursor protein; ASD; autism spectrum disorder; CAT; catalase; CNS; central nervous syste
Molecular cloning, transcriptional profiling, and subcellular localization of signal transducer and activator of transcription 2 (STAT2) ortholog from rock bream, Oplegnathus fasciatus
Keywords: STAT2; signal transducer and activator of transcription 2; JAK; Janus kinase; IL-10; interleukin-10; TYK2; tyrosine kinase 2; IFN; interferon; ISGF3; IFN-stimulated gene factor 3; ISG; IFN-stimulated gene; CREB; cyclic AMP-response element-binding protein
MicroRNA-34a targets regulator of calcineurin 1 to modulate endothelial inflammation after fetal cardiac bypass in goat placenta
Keywords: MicroRNAs; Placental insufficiency; Endothelial cells; Inflammation; Fetus; Cardiopulmonary bypass; miRNA; microRNA; miR-34a; miRNA-34a; mRNA; messenger RNA; 3'-untranslated regions (UTRs); untranslated region; RCAN1; regulator of calcineurin 1; NFATC1;
Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction
Keywords: PDTC; pyrrolidine dithiocarbamate; RCAN1; regulator of calcineurin 1; NF-κB; nuclear factor-κB; NFAT; nuclear factors of activated T cells; PDTC; Calcineurin; RCAN1; Inflammation;
Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model
Keywords: AR; aspect ratio; BrdU; bromodeoxyuridine; CaN; calcineurin; DAPI; 4',6-diamidino-2-phenylindole; DCX; doublecortin; Drp1; dynamin-related protein 1; DS; Down syndrome; L-Opa; long Opa1; Mdivi-1; mitochondrial division inhibitor 1; Mnf2; mitofusin 2; NPCs
RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation
Keywords: RCAN1; Salmonella; Colitis; Inflammation; JNK activation;
Quercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression
Keywords: Calcineurin; Quercetin; RCAN1; NFAT; LxVP-motif; Cyclosporine A; Cytokine expression;
Protein degradation in a LAMP-2-deficient B-lymphoblastoid cell line from a patient with Danon disease
Keywords: Danon disease; LAMP-2; Autophagy; Ubiquitin proteasome; Chaperone-mediated autophagy; Alpha-synuclein; IkappaB; Rcan1; glyceraldehyde-3-phosphate dehydrogenase;
PKA regulates calcineurin function through the phosphorylation of RCAN1: Identification of a novel phosphorylation site
Keywords: Calcineurin; RCAN1; Phosphorylation; PKA; InflammationRCAN1, regulator of calcineurin 1; PKA, protein kinase A; NFAT, nuclear factors of activated T cells
RCAN 1 and 3 proteins regulate thymic positive selection
Keywords: Thymocyte positive selection; RCAN1; RCAN3; Calcineurin; NFATc; RAF kinase; BM; bone marrow; CIC; calcipressin (renamed as RCAN) inhibitor of calcineurin; CN; calcineurin; DP; double positive; DN; double negative; mAb; monoclonal antibody; NFATc; cytosoli
Enzymatic and thermodynamic analysis of calcineurin inhibition by RCAN1
Keywords: Calcineurin activity; RCAN1; Isothermal titration calorimetry;
Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7
Keywords: APP; RCAN1; Apoptosis; Proteasome; Down syndrome; Alzheimer's disease;
Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion
Keywords: Circadian rhythms; Ischemia-reperfusion; Signal transduction; Calcineurin; Rcan1; Cardioprotection;
Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome
Keywords: 2-DE; two-dimensional gel electrophoresis; BrdU; bromodeoxyuridine; CACYBP; calcyclin-binding protein; DAB; 3,3â²-diaminobenzidine; DAVID; Database for Annotation, Visualization, and Integrated Discovery; DS; Down syndrome; E14.5; embryonic day 14.5; GE;
Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease
Keywords: RCAN1; regulator of calcineurin 1; GSK-3β; glycogen synthase kinase-3β; ANT; (mitochondrial) adenine nucleotide transporter; mtPTP; mitochondrial permeability transition pore; RCAN1; Neurodegeneration; Oxidative stress; Alzheimer disease; Mitochondria;
The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7
Keywords: RCAN1; DSCR1; STAT2; Proteasome; FBW7; Inflammation; Interferon-α;
A fluorescent polarization-based assay for the identification of disruptors of the RCAN1–calcineurin A protein complex
Keywords: RCAN1; Calcineurin A; NFAT; Immunosuppression; Fluorescence polarization assay; Millipolarization units
Basic-Liver, Pancreas, and Biliary TractRegulator of Calcineurin 1 Controls Growth Plasticity of Adult Pancreas
Keywords: Regulator of Calcineurin 1; Rcan1; Nuclear Factor of Activated T Cells; NFAT; Calcineurin; Pancreas; Growth; BrdU; bromodeoxyuridine; CCK; cholecystokinin; ChIP; chromatin immunoprecipitation; CN; calcineurin; ER; estrogen receptor; GFP; green fluorescent
Upregulation of DSCR1 (RCAN1 or Adapt78) in the peri-infarct cortex after experimental stroke
Keywords: DSCR1; RCAN1; Adapt78; Stroke; Interleukin-1β; Tumor necrosis factor α; Inflammation
Regulation of vascular function by RCAN1 (ADAPT78)
Keywords: Calcineurin; RCAN1; Adapt78; Vascular; Endothelial cells; Isoform 1; Isoform 4; Calcium
Brain expression of the calcineurin inhibitor RCAN1 (Adapt78)
Keywords: Calcineurin; RCAN1; Adapt78; Isoform 1; Isoform 4; Brain expression; Calcium