Keywords: RdRp، RNA پلیمراز وابسته به RNA; HDV, hepatitis delta virus; RNP, ribonucleoprotein; HBV, hepatitis B virus; HDAg, hepatitis delta antigen; RdRp, RNA-dependent RNA polymerase; ADAR, adenosine deaminase acting on RNA; ORF, open reading frame; S-HDAg, small-HDAg; L-HDAg, large-HDAg; DIPA,
مقالات ISI RdRp، RNA پلیمراز وابسته به RNA (ترجمه نشده)
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Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase
Keywords: RdRp، RNA پلیمراز وابسته به RNA; 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole; 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole; Dengue virus; NS5 RdRp inhibitors; Antiviral activityDENV, dengue virus; NS, non-structural protein; RdRp, RNA-dependent RNA polymerase
dsRNA interference on expression of a RNA-dependent RNA polymerase gene of Bombyx mori cytoplasmic polyhedrosis virus
Keywords: RdRp، RNA پلیمراز وابسته به RNA; BmCPV, Bombyx mori cytoplasmic polyhedrosis virus; RNA, ribonucleic acid; RNAi, RNA interference; dsRNA, double-stranded RNA; siRNA, small interfering RNA; RDRP, RNA-dependent RNA polymerase; BmCPV-RDRP, Bombyx mori cytoplasmic polyhedrosis virus RNA-depe
The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via suppression of its RNP expression
Keywords: RdRp، RNA پلیمراز وابسته به RNA; Influenza A virus; RNA polymerase; Ribonucleoprotein; PA subunit; InhibitorRNP, ribonucleoprotein complex; RdRp, RNA-dependent RNA polymerase; WSN, A/WSN/33 (H1N1); NT, A/NorthernTerritory/60/68 (H3N2); HK, A/HongKong/56/97 (H5N1); VN, A/Vietnam/1194/2004
Systemic RNA interference is not triggered by locally-induced RNA interference in a plant pathogenic fungus, Rosellinia necatrix
Keywords: RdRp، RNA پلیمراز وابسته به RNA; RNAi, RNA interference; RdRP, RNA-dependent RNA polymerase; siRNA, small interfering RNAAutonomously replicating vector; RNA interference; Rosellinia necatrix; Systemic RNAi
Identification of 23 novel conserved microRNAs in three rice cultivars
Keywords: RdRp، RNA پلیمراز وابسته به RNA; miRNAs, microRNAs; qPCR, quantitative real-time polymerase chain reaction; sRNA, small RNA; siRNAs, short interfering RNAs; pri-miRNA, primary RNA precursors; RDRP, RNA-dependent RNA polymerase; PAGE, polyacrylamide gel electrophoresis; CT, threshold cycl
Comparison of vRNA and cRNA based reporters for detection of influenza replication
Keywords: RdRp، RNA پلیمراز وابسته به RNA; cRNA, complementary RNA; hpi, hours post infection; Pol, polymerase; RdRp, RNA-dependent RNA polymerase; RNAi, RNA interference; siRNA, short interfering RNA; vRNA, virion genomic RNAInfluenza; vRNA; cRNA; RNA interference; Replication
Role of Motif B Loop in Allosteric Regulation of RNA-Dependent RNA Polymerization Activity
Keywords: RdRp، RNA پلیمراز وابسته به RNA; RdRP, RNA-dependent RNA polymerase; MD, molecular dynamics; RT, reverse transcriptase; dsRNA, double-stranded RNA; rNTP, ribonucleoside triphosphate; NNI, non-nucleoside inhibitorantiviral therapy; drug discovery; RNA viruses; RNA-dependent RNA polymerase
2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase
Keywords: RdRp، RNA پلیمراز وابسته به RNA; Antiviral agents; Hepatitis C; HCV NS5B polymerase; ThiazolidinonesAP, allosteric pocket; HCV, hepatitis C virus; NI, nucleoside inhibitor; NNI, non-nucleoside inhibitor; PP-I, palm pocket-I; RdRp, RNA-dependent RNA polymerase; SP, subpocket; TP, thumb po
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors
Keywords: RdRp، RNA پلیمراز وابسته به RNA; Hepatitis C virus; NS5B polymerase; Virtual screening; NS5B inhibitors; Thumb pocketAP, allosteric pocket; HCV, hepatitis C virus; NI, nucleoside inhibitor; NNI, non-nucleoside inhibitor; PP-1, palm pocket-1; RdRp, RNA-dependent RNA polymerase; SP, subpoc
Effect of the methyltransferase domain of Japanese encephalitis virus NS5 on the polymerase activity
Keywords: RdRp، RNA پلیمراز وابسته به RNA; DV, dengue virus; E. coli, Escherichia coli; JEV, Japanese encephalitis virus; KV, Kunjin virus; MTase, methyltransferase; nt, nucleotides; preM, pre-membrane; RdRp, RNA-dependent RNA polymerase; SAM, S-adenosyl-l-methionine; UTR, untranslated regions; WN
Detection of members of the Secoviridae in the Tallgrass Prairie Preserve, Osage County, Oklahoma, USA
Keywords: RdRp، RNA پلیمراز وابسته به RNA; ICTV, International Committee for the Taxonomy of Viruses; PVBE, Plant Virus Biodiversity and Ecology; TPP, Tallgrass Prairie Preserve; RdRp, RNA-dependent RNA polymerase; LCP, large coat protein; NJ, Neighbor Joining; ML, Maximum Likelihood; LG, Le and G
Reprint of: Core protein-mediated 5′–3′ annealing of the West Nile virus genomic RNA in vitro
Keywords: RdRp، RNA پلیمراز وابسته به RNA; CS, conserved sequence; DAR, downstream AUG region; DB, dumbbell-like structure; DENV, dengue virus; JEV, Japanese encephalitis virus; ORF, open reading frame; RdRp, RNA-dependent RNA polymerase; sfRNA, subgenomic flavivirus RNA; TBEV, tick-borne encephal
Endogenous RNA interference of chalcone synthase genes in soybean: Formation of double-stranded RNA of GmIRCHS transcripts and structure of the 5′ and 3′ ends of short interfering RNAs
Keywords: RdRp، RNA پلیمراز وابسته به RNA; AGO, Argonaute; CHS, chalcone synthase; DCL, Dicer-like enzyme; dsRNA, double-stranded RNA; FW, fresh weight; IR, inverted repeat; miRNA, microRNA; nt, nucleotides; PTGS, post-transcriptional gene silencing; RdRP, RNA-dependent RNA polymerase; RISC, RNA-i
An Objective Assessment of Conformational Variability in Complexes of Hepatitis C Virus Polymerase with Non-Nucleoside Inhibitors
Keywords: RdRp، RNA پلیمراز وابسته به RNA; HCV, hepatitis C virus; NS5B, nonstructural protein 5B; NS3, nonstructural protein 3; PDB, Protein Data Bank; esd, estimated standard deviation; RdRp, RNA-dependent RNA polymerase; NNI, non-nucleoside inhibitorhepatitis C virus; NS5B polymerase; non-nucle
Molecular Dynamics Simulations of Viral RNA Polymerases Link Conserved and Correlated Motions of Functional Elements to Fidelity
Keywords: RdRp، RNA پلیمراز وابسته به RNA; MD simulation; polymerase; poliovirus; conformational change; fidelityPV, poliovirus; CVB3, coxsackievirus B3; HRV16, human rhinovirus type 16; FMDV, foot-and-mouth disease virus; RdRp, RNA-dependent RNA polymerase; NTP, nucleoside triphosphate; MD, molec
Hijacking hepatitis C viral replication with a non-coding replicative RNA
Keywords: RdRp، RNA پلیمراز وابسته به RNA; HCV replication; Antiviral strategyHCV, hepatitis C virus; RdRp, RNA-dependent RNA polymerase; RC, replication complex; UTR, untranslated region
Effect of reaction conditions and 3AB on the mutation rate of poliovirus RNA-dependent RNA polymerase in a α-complementation assay
Keywords: RdRp، RNA پلیمراز وابسته به RNA; RDRP, RNA-dependent RNA polymerase; IPTG, isopropyl β-d-1-thiogalactopyranoside; X-Gal, bromo-chloro-indolyl-galactopyranoside; DTT, dithiothreitol; EDTA, ethylenediaminetetraacetic acid; GST, glutathione S-transferase; CIP, calf intestinal alkaline phosp
Strategies for development of dengue virus inhibitors
Keywords: RdRp، RNA پلیمراز وابسته به RNA; DENV, dengue virus; WNV, West Nile virus; YFV, yellow fever virus; HCV, hepatitis C virus; HTS, high-throughput screening; RdRp, RNA-dependent RNA polymerase; HIV, human immunodeficiency virus; HSV, herpes simplex virus; UTR, untranslated region; SAR, str
Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system
Keywords: RdRp، RNA پلیمراز وابسته به RNA; HCV, hepatitis C virus; RdRp, RNA-dependent RNA polymerase; CK, casein kinase; UTR, untranslated regionHepatitis; RNA polymerase; NS5A protein; Phosphorylation
Characterization of the siRNAs associated with peach latent mosaic viroid infection
Keywords: RdRp، RNA پلیمراز وابسته به RNA; DCL, Dicer-like; dsRNA, double-stranded RNA; ncRNA, non-coding RNA; PLMVd, peach latent mosaic viroid; PSTVd, potato spindle tuber viroid; PTGS, post-transcriptional gene silencing; RdRp, RNA-dependent RNA polymerase; RISC, RNA-induced silencing complex;
Binding of 2′-Amino-2′-Deoxycytidine-5′-Triphosphate to Norovirus Polymerase Induces Rearrangement of the Active Site
Keywords: RdRp، RNA پلیمراز وابسته به RNA; ACT, 2′-amino-2′-deoxy-cytidine-5′-triphosphate; NCT, 5-nitro-cytidine-5′-triphosphate; NV, norovirus; RdRP, RNA-dependent RNA polymerase; PDB, Protein Data Bankcalicivirus; positive-strand RNA virus; viral replication; enzyme inhibitor; antiviral
Infectious Bursal Disease Virus: Ribonucleoprotein Complexes of a Double-Stranded RNA Virus
Keywords: RdRp، RNA پلیمراز وابسته به RNA; BSA, bovine serum albumin; dsDNA/RNA, double-stranded DNA/RNA; IBDV, infectious bursal disease virus; IPNV, infectious pancreatic necrosis virus; ORF, open-reading frame; PBS, phosphate-buffered saline; RdRp, RNA-dependent RNA polymerase; RNP, ribonucleop
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step
Keywords: RdRp، RNA پلیمراز وابسته به RNA; HCV, hepatitis C virus; CMV, cytomegalovirus; HSV, herpes simplex virus; HBV, hepatitis B virus; dsRNA, double-stranded ribonucleic acid; ssRNA, single-stranded ribonucleic acid; RdRp, RNA-dependent RNA polymerase; WT, wild-type; GTP, guanosine triphospha
Role of host protein Ebp1 in influenza virus growth: Intracellular localization of Ebp1 in virus-infected and uninfected cells
Keywords: RdRp، RNA پلیمراز وابسته به RNA; Ebp1, ErbB3-binding protein 1; RdRp, RNA-dependent RNA polymerase; P proteins, PB1, PB2 and PA; SDS, sodium dodecyl sulfate; PAGE, polyacrylamide gel electrophoresis; ErbB3, epidermal receptor tyrosine kinase; HDAC2, histone deacetylase 2; Rb, retinoblast
Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B
Keywords: RdRp، RNA پلیمراز وابسته به RNA; HCV, Hepatitis C virus; RdRp, RNA-dependent RNA polymerase; ER, endoplasmic reticulum; M2PK, M2 type pyruvate kinase; LPK, L type pyruvate kinaseHepatitis C virus; NS5B; L type pyruvate kinase; M2 type pyruvate kinase
Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from Dengue virus as a target
Keywords: RdRp، RNA پلیمراز وابسته به RNA; DENV, Dengue virus; DHF, dengue hemorrhagic fever; DENV3, dengue virus serotype 3; NS3, non-structural protein 3; NS5, non-structural protein 5; NS2B, non structural protein 2B; NS2A, non-structural protein 2A; RdRp, RNA-dependent RNA polymerase; FL NS3,
A Turnip yellow mosaic virus infection system in Arabidopsis suspension cell culture
Keywords: RdRp، RNA پلیمراز وابسته به RNA; TYMV, Turnip yellow mosaic virus; CP, coat protein; sg, subgenomic; PCR, polymerase chain reaction; GUS, β-glucuronidase; PAGE, polyacrylamide gel electrophoresis; RdRp, RNA-dependent RNA polymerase; wt, wild-type; hpt, hour post-transfection; PTGS, post-
Stabilization of Poliovirus Polymerase by NTP Binding and Fingers–Thumb Interactions
Keywords: RdRp، RNA پلیمراز وابسته به RNA; polymerase; NTP binding; thermal stability; virus; RNAANS, 2-anilinonaphthalene-6-sulfonate; RdRP, RNA-dependent RNA polymerase
Mosaic Structure of Human Coronavirus NL63, One Thousand Years of Evolution
Keywords: RdRp، RNA پلیمراز وابسته به RNA; aa, amino acid residue(s); RdRp, RNA-dependent RNA polymerase; ACE, angiotensin converting enzymecoronavirus; HCoV-NL63; recombination; evolution; molecular clock
Crystal structure of the serine protease domain of Sesbania mosaic virus polyprotein and mutational analysis of residues forming the S1-binding pocket
Keywords: RdRp، RNA پلیمراز وابسته به RNA; SeMV, Sesbania mosaic virus; ss-RNA, single-stranded RNA; ORF, open reading frame; VPg, viral protein genome linked; RdRP, RNA-dependent RNA polymerase; MIRAS, multiple isomorphous replacement and anomalous scattering; IPTG, isopropyl thiogalactoside; PCM
Histidine Triad-like Motif of the Rotavirus NSP2 Octamer Mediates both RTPase and NTPase Activities
Keywords: RdRp، RNA پلیمراز وابسته به RNA; ds, double-stranded; ss, single-stranded; DLP, double-layered particle; RdRP, RNA-dependent RNA polymerase; NTPase, nucleoside-triphosphate phosphohydrolase; PKCI, protein kinase C-interacting protein; HIT, histidine triad; RTPase, RNA triphosphatase; VLS