Keywords: متابولیت های واکنشی; Usnic acid; Liver failure; Reactive metabolites; Drug toxicity; Hepatotoxicity;
مقالات ISI متابولیت های واکنشی (ترجمه نشده)
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Keywords: متابولیت های واکنشی; Hepersensitivity; Severe cutaneous adverse reactions; Drug-induced liver injury; Human leukocyte antigen; Reactive metabolites; Hapten concept; p-i concept; Altered peptide repertory concept; APC; antigen presenting cell; BB; Bandrowski's base; DILI; drug
Keywords: متابولیت های واکنشی; Hepatotoxicity; Reactive metabolites; Mitochondria; Hepatocellular; Cholestasis;
Keywords: متابولیت های واکنشی; ADMET; absorption, distribution, metabolism, excretion, toxicity; AHR; aryl hydrocarbon receptor; AUC; area under the curve; BVU; (E)-5-(2-bromovinyl) uracil; CAR; constitutive androstane receptor; cMOAT; Canalicular multispecific organic anion transporte
Keywords: متابولیت های واکنشی; Pyrrolizidine alkaloids; Hepatotoxicity; Metabolic activation; Reactive metabolites; Hepatic sinusoidal endothelial cell damage; Pyrrole-protein adductsCYP, cytochrome P450; DABA, 4-(dimethylamino)benzaldehyde; DHPA, dehydropyrrolizidine alkaloid; DHR, de
Keywords: متابولیت های واکنشی; Electrochemistry; Oxidation; Mass spectrometry; Reactive metabolites
Keywords: متابولیت های واکنشی; Methyleugenol; Metabolic activation; Glutathione conjugates; Cysteine conjugates; Reactive metabolites; Mechanism actionME, methyleugenol; GSH, glutathione; GS-1′OME, 3′-(glutathione-S-yl)-1′-oxo-2′,3′-dihydromethyleugenol; GSTs, glutathione-S -transferas
Keywords: متابولیت های واکنشی; Type 2 diabetes mellitus; Reactive metabolites; Antioxidants; Polymorphisms; Oxidative stress
Keywords: متابولیت های واکنشی; Idiosyncratic hepatotoxicity; Oxidative stress; Reactive metabolites; Adverse drug reactions; Drug induced liver injury; DILI
Toxicité hépatique des inhibiteurs des tyrosines kinases : mécanismes en cause et conséquences pratiques
Keywords: متابولیت های واکنشی; hépatotoxicité; Inhibiteurs des tyrosines kinases; Métabolites réactifs; Recommandations de surveillance; Hepatotoxicity; Tyrosine kinase inhibitors; Reactive metabolites; Monitoring recommendations;
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
Keywords: متابولیت های واکنشی; Diabetic retinopathy; Reactive metabolites; TRPC cation channels; MethylGlyoxal; Vasoregression; Glyoxalase1; DR; Diabetic Retinopathy; GLO1; Glyoxalase 1; GSH; Glutathione; GSSG; Glutathione disulfide; HTA; Hemithioacetal; MEF; Mouse Embryonic Fibroblast
Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury
Keywords: متابولیت های واکنشی; AUC; area under receiver operating characteristic curve; BSO; L-buthionine-S,R-sulfoximine; BW; boxed warning; Cmax; therapeutic maximum plasma concentration; CYP; cytochrome P450; DILI; drug-induced liver injury; DMSO; dimethyl sulfoxide; FBS; fetal bovi
Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux
Keywords: متابولیت های واکنشی; Methylglyoxal; Reactive metabolites; Glucose metabolism; Nutrient signalling; Protein quality control system; Heat shock proteins;
Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2
Keywords: متابولیت های واکنشی; MBI; mechanism-based inhibition; RMs; reactive metabolites; CYPs; cytochrome P450 enzymes; GSH; reduced glutathione; HLMs; human liver microsomes; NADPH; β-nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt; MI complex; metabolite
Minimizing DILI risk in drug discovery — A screening tool for drug candidates
Keywords: متابولیت های واکنشی; Hepatotoxicity; Liver injury; DILI assessment; Reactive metabolites; BSEP inhibition; Cytotoxicity; Mitochondrial toxicity
Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen
Keywords: متابولیت های واکنشی; Cytochrome P450; Reactive metabolites; Adverse drug reactions; Bioinactivation; Glutathione-S-transferase P1-1; Polymorphism;
Mechanistic insights into the bioactivation of phenacetin to reactive metabolites: A DFT study
Keywords: متابولیت های واکنشی; Phenacetin; Carcinogenicity; Density functional theory; Reactive metabolites; Electrophilicity; Quinone imine;
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites
Keywords: متابولیت های واکنشی; DTNB; 5,5â²-dithiobis(2-nitrobenzoic acid); GSH; reduced glutathione; GTP; guanosine-5â²-triphosphate; HLM; human liver microsomes; NAC; N-acetyl-L-cysteine; NEM; N-ethyl-maleimide; MEM; minimal essential medium; MTT; (3-(4,5-dimethylthiazol-2-yl)-2,5-d
Bioactivation of bisphenol A and its analogs (BPF, BPAF, BPZ and DMBPA) in human liver microsomes
Keywords: متابولیت های واکنشی; BP; bisphenol; BPA; bisphenol A; BPF; bisphenol F; BPAF; bisphenol AF; BPZ; bisphenol Z; DMBPA; 3,3â²-dimethyl BPA; ER; estrogen receptor; ESI; electrospray ionization; GSH; reduced glutathione; HCA; hydroxycumyl alcohol; LC-MS/MS; liquid chromatograph
Molecular and cellular pharmacologyBioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase does not change its apoptotic stimuli properties in regard to sensitive and multidrug resistant leukaemia HL60 cells
Keywords: متابولیت های واکنشی; Mitoxantrone; NADPH cytochrome P450 reductase; Reactive metabolites; HL60 human promyelocytic leukaemia; Multidrug resistance; Apoptosis;
Application of exogenous mixture of glutathione and stable isotope labeled glutathione for trapping reactive metabolites in cryopreserved human hepatocytes. Detection of the glutathione conjugates using high resolution accurate mass spectrometry
Keywords: متابولیت های واکنشی; Glutathione conjugation; Troglitazone; Reactive metabolites; Stable isotope label; LC–HRAMS; Human hepatocytes
Mechanisms of Drug-induced Liver Injury
Keywords: متابولیت های واکنشی; Idiosyncratic drug-induced liver injury; Cell death; Reactive metabolites; Oxidative stress; Stress signaling; Mitochondria; Adaptive immunity; HLA associations;
Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors
Keywords: متابولیت های واکنشی; 11β-HSD1 inhibitors; Pharmacokinetics; Reactive metabolites;
LC–MS-based metabolomics in profiling of drug metabolism and bioactivation
Keywords: متابولیت های واکنشی; Metabolomics; Drug metabolism; Reactive metabolites; Multivariate data analysis
Assessment of drug–drug interactions caused by metabolism-dependent cytochrome P450 inhibition
Keywords: متابولیت های واکنشی; Metabolism-dependent inhibition; Mechanism-based inhibition; Reactive metabolites; Drug–drug interaction; Cytochrome P450; Reversibility
Overview of strategies for addressing BRIs in drug discovery: Impact on optimization and design
Keywords: متابولیت های واکنشی; CYP; cytochrome P450; DIT; drug-induced toxicity; GSH; reduced glutathione; LC-MS/MS; liquid chromatography-tandem mass spectrometry; PCB; protein covalent binding; Cytochrome P450 (CYP); Drug design; Reactive metabolites;
Sulfenic acids as reactive intermediates in xenobiotic metabolism
Keywords: متابولیت های واکنشی; Sulfenic acid; Xenobiotics; Metabolism; Cytochrome P450; Oxidation; Reactive metabolites
d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry
Keywords: متابولیت های واکنشی; Bioactivation; LC/MS liquid chromatography mass spectrometry; Reactive metabolites; Covalent binding; Peptide d-isomer and peptide adducts
Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity
Keywords: متابولیت های واکنشی; Troglitazone; Reactive metabolites; Hepatotoxicity; Glutathione; Human hepatocytes; Thiazolidinedione
Filling and mining the reactive metabolite target protein database
Keywords: متابولیت های واکنشی; Hepatotoxicity; Cytotoxicity; Reactive metabolites; Covalent binding; Post-translational modification
Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells
Keywords: متابولیت های واکنشی; Mitoxantrone; NADPH cytochrome P450 reductase; Reactive metabolites; HL60 human promyelocytic leukaemia; Multidrug resistance;
In vitro and animal models of drug-induced blood dyscrasias
Keywords: متابولیت های واکنشی; Idiosyncratic drug reactions; Reactive metabolites; Agranulocytosis; Aplastic anemia; Thrombocytopenia
Investigation of cysteinyl protein adducts of benzene diolepoxide
Keywords: متابولیت های واکنشی; Benzene; Reactive metabolites; Benzene diolepoxide; Protein adducts; Sulfhydryl groups;
Role of drug metabolism for breaking tolerance and the localization of drug hypersensitivity
Keywords: متابولیت های واکنشی; Reactive metabolites; Penicillamine; Nevirapine; Animal models;
Sporadic colorectal cancer - role of the commensal microbiota
Keywords: متابولیت های واکنشی; Colonic microbiota; Colorectal cancer; Inflammation; Carbohydrate expression; Reactive metabolites;
A semi-automated method for measuring the potential for protein covalent binding in drug discovery
Keywords: متابولیت های واکنشی; Covalent protein binding; Human; Idiosyncratic drug reactions; In vitro methods; Rat; Radiolabeled compounds; Reactive metabolites;
Drug-induced oxidative stress in rat liver from a toxicogenomics perspective
Keywords: متابولیت های واکنشی; Stat-3; signal transducers and activators of transcription-3; NFκB; nuclear factor κB; PPARα; peroxisome proliferator-activated receptor α; Nrf2; nuclear factor erythroid 2 related factor 2; MRP3; multidrug resistance-associated protein 3; mEphx/cEphx
An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics
Keywords: متابولیت های واکنشی; BSO; l-buthionine S,R-sulphoximine; CYP; cytochrome P450; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl-sulphoxide; GSH: reduced glutathione; MTT; 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide; PBS; phosphate buffered saline; M