Keywords: فعال سازی گیرنده; Receptor state affinity constants; Constitutive activity; Agonist bias; System bias; Monod-Wyman-Changeux model; Observed affinity; Efficacy; Receptor activation; Active state; Inactive state;
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Keywords: فعال سازی گیرنده; VEGF; vascular endothelial growth factor; VEGFR2; VEGF receptor 2; Nrp; Neuropilin; PlGF; placenta growth factor; PLCγ; phospholipase Cγ; VE-cadherin; vascular endothelial cadherin; TSAd; T-cell-specific adapter; HSPGs; heparan sulfate proteoglycans; Hs
Keywords: فعال سازی گیرنده; Growth factor; Signal transduction; Receptor tyrosine kinase; Receptor activation; Propeptide recognition;
Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline
Keywords: فعال سازی گیرنده; Muscarinic acetylcholine receptors; Membrane cholesterol; Xanomeline; Receptor activation; Molecular dynamics; Cholesterol (PubChem CID: 5997); Methyl beta-cyclodextrin (PubChem CID: 51051622); N-methyl scopolamine (PubChem CID: 5459110); Xanomeline (Pubc
Assessing the real-time activation of the cannabinoid CB1 receptor and the associated structural changes using a FRET biosensor
Keywords: فعال سازی گیرنده; CB1; cannabinoid type 1 receptor; FRET; fluorescence resonance energy transfer; GPCRs; G protein-coupled receptors; HD; Huntington's disease; TM; transmembrane; G-proteins; GTP binding-proteins; cAMP; cyclic adenosine monophosphate; ERK1/2; extracellula
Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family
Keywords: فعال سازی گیرنده; GPCR; Extracellular loop; Ligand-binding; Receptor activation; Signalling; Family B;
Persistent GnRH receptor activation in pituitary αT3-1 cells analyzed with a label-free technology
Keywords: فعال سازی گیرنده; Binding kinetics; Residence time; GnRH; Wash-out; Label-free; Receptor activation;
A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3
Keywords: فعال سازی گیرنده; Relaxin-3; RXFP3; GPCR; Receptor activation; Ligand binding;
Human G protein-coupled receptor studies in Saccharomyces cerevisiae
Keywords: فعال سازی گیرنده; Human G protein-coupled receptor; Saccharomyces cerevisiae; Yeast screening; Receptor activation;
GPCR crystal structures: Medicinal chemistry in the pocket
Keywords: فعال سازی گیرنده; GPCR; Medicinal chemistry; Crystal structure; Drug discovery; Receptor activation; Ligand–receptor interactions; Receptor selectivity
An aspartate in the second extracellular loop of the α1B adrenoceptor regulates agonist binding
Keywords: فعال سازی گیرنده; GPCR; α1B Adrenergic receptor; Receptor activation; Second extracellular loop;
Importance of recognition loops B and D in the activation of human 5-HT3 receptors by 5-HT and meta-chlorophenylbiguanide
Keywords: فعال سازی گیرنده; 5-HT; mCPBG; 5-HT3A receptor; 5-HT3AB receptor; Receptor activation; 5-HT; 5-hydroxytryptamine; mCPBG; meta-chlorophenylbiguanide; 5-HT3AR; 5-hydroxytryptamine type 3A receptor; 5-HT3ABR; 5-hydroxytryptamine type 3AB receptor; nAChR; nicotinic acetylcholi
Structural studies of GDNF family ligands with their receptors-Insights into ligand recognition and activation of receptor tyrosine kinase RET
Keywords: فعال سازی گیرنده; Receptor tyrosine kinase RET; GDNF family ligand; Ligand recognition; Receptor activation;
The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors
Keywords: فعال سازی گیرنده; Mutagenesis; G protein-coupled receptors; Receptor activation; Ligand binding site; Overlap extension mutagenesis; EL2 loop exchange;
A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction
Keywords: فعال سازی گیرنده; GLP-1; Exendin-4; Glucagon; GPCR; Receptor activation
Analysis by substituted cysteine scanning mutagenesis of the fourth transmembrane domain of the CXCR4 receptor in its inactive and active state
Keywords: فعال سازی گیرنده; CXCR4; G Protein-coupled receptor; Substituted-cysteine accessibility method; Binding pocket; Receptor activation
The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation
Keywords: فعال سازی گیرنده; G protein-coupled receptor; Adenosine A1 receptor; Receptor activation; S. cerevisiae; Extracellular loops;
Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation
Keywords: فعال سازی گیرنده; EGF, epidermal growth factor; EGFR, EGF receptor; RTK, receptor tyrosine kinase; SPR, surface plasmon resonanceEpidermal growth factor; Protein engineering; Receptor activation; Receptor tyrosine kinase; Kinetic binding rate
Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes - Role of insulin and IGF-I receptors
Keywords: فعال سازی گیرنده; Growth factors; Hybrid receptors; Receptor activation; DNA synthesis; Glucose metabolism;
Allostery in pharmacology: Thermodynamics, evolution and design
Keywords: فعال سازی گیرنده; Receptor activation; Ligand-gated ion channels; Homo/hetero/tropic cooperativity; Thermodynamic discrimination of efficacy; Conformational fluctuations; Statistical–energetic couplingGABAA, A-type γ-aminobutyric acid; KNF, Koshland, Némethy and Filmer; MW
Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides
Keywords: فعال سازی گیرنده; G protein-coupled receptor; Secretin receptor; Receptor activation; Cyclic peptide; Hexapeptide; Molecular modeling
The CB2 cannabinoid receptor regulates human sperm cell motility
Keywords: فعال سازی گیرنده; Cannabinoids; receptor activation; human sperm motility
Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling
Keywords: فعال سازی گیرنده; Gal-1; galectin-1; TLR; TOLL-like receptors; LPS; endotoxin lipopolysaccharide; WT; wild-type; TS; T. cruzi trans-sialidase; TSâAsp98-Glu; the catalytically inactive mutant TS; MAL-2; sialyl α-2,3-specific Maackia amurensis lectin; SNA; sialyl α-2,6-s
Insight into the structural mechanism of the bi-modal action of an NCAM mimetic, the C3 peptide
Keywords: فعال سازی گیرنده; Fibroblast growth factor receptor, FGFR; Neural cell adhesion molecule, NCAM; Mimetic peptide, C3; Receptor activation; Surface plasmon resonance, SPR
Spare interactions of highly potent [Arg14,Lys15]nociceptin for cooperative induction of ORL1 receptor activation
Keywords: فعال سازی گیرنده; EL2; The second extracellular loop; GPCR; G protein-coupled receptor; ORL1; Opioid receptor-like receptor 1; TM5; The fifth transmembrane domain; Binding site; Nociceptin; Receptor activation; Site-directed mutagenesis; Synergistic effect;
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation
Keywords: فعال سازی گیرنده; Cannabinoid; Cannabinoid receptor; CB1; G-protein-coupled receptor; Ligand binding; Receptor activation