Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes - Role of insulin and IGF-I receptors

► In preadipocytes IR, IGF-IR and insulin/IGF-I hybrid receptors were detected. ► Insulin and IGF-I activate their cognate receptors and IGF-I also hybrid receptors. ► IGF-II activates IR, IGF-IR and insulin/IGF-I hybrid receptors. ► Insulin and IGF-I are partial agonists to each other's receptors.