
Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates
Keywords: سمیت تولید مثل; EST; embryonic stem cell test; ECVAM; European Center for the Validation of Alternative Methods; PBPK; physiologically based pharmacokinetics; MIC; metabolically inapplicable candidate; PBS; phosphate buffered saline; DMSO; dimethyl sulfoxide; MD; maximum