Keywords: Cochlea; Immunity; Macrophage; Inflammation; TLR; Toll-like receptor; RIG-I; Retinoic acid inducible gene-I; MDA5; Melanoma differentiation-associated gene 5; TGF-β; Transforming growth factor beta; MHC-II; major histocompatibility complex II; ICAM-1; In
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Keywords: ROI; reactive oxygen intermediates; VEGF; vascular endothelial growth factor; Arg-1; Arginase-1; HO-1; Heme Oxygenase-1; SRXN1; Sulphiredoxin-1; iNOS; inducible nitric oxide synthase; Th1; T-helper cells1; IFN-γ; interferon gamma; IL-4; interleukin-4; Th
Keywords: Zika virus; Type I interferon; RIG-I; MDA5; RIG-I signaling; Flavivirus; Viral antagonism; Innate immunity; JAK/STAT signaling; Antibody; T cells;
Keywords: Immunosenescence; Monocyte; Dendritic cell; Aging; RIG-I; Inflammasomes;
Keywords: Plasmacytoid dendritic cells; rhinovirus; IFN-α; asthma; IgE; omalizumab; FcεRα; IRF; Interferon regulatory factor; pDC; Plasmacytoid dendritic cell; PROSE; Preventative Omalizumab or Step-Up Therapy for Fall Exacerbations; RIG-I; Retinoic acid-induc
Keywords: PRR; pattern recognition receptor; PAMP; pathogen-associated molecular pattern; DAMP; danger-associated molecular pattern; NLRP3; NOD-, LRR- and pyrin domain-containing 3; TLR; toll-like receptor; CLR; C-type lectin receptor; NLR; NOD-like receptor; RIG-I
Keywords: LPS; lipopolysaccharide; TLR; Toll-like receptor; NKT cells; natural killer T cells; NOD; nucleotide-binding oligomerization domain-containing protein; SNP; single nucleotide polymorphism; MDSC; myeloid-derived suppressor cell; PSA; polysaccharide A; RI
Keywords: α-HL; α-hemolysin; AIM2; absent in melanoma; ASC; apoptosis-associated speck-likeprotein containing a CARD; BIR; baculoviral inhibitor of apoptosis repeat; CARD; caspase activation and recruitment domain; Caspase; cysteine aspartic acid-specific proteas
Keywords: DAMP; damage associated molecular pattern; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MyD88; myeloid differentiation primary response gene 88; NF-κB; nuclear factor kappa B; NLR; nucleotide-binding domain and leucine-rich repeat; NO
Keywords: AD; atopic dermatitis; AMP; antimicrobial peptide; CAPS; cryopyrin-associated periodic syndrome; CPA; carboxypeptidase A; CTMC; connective tissue mast cell; dsRNA; double-stranded RNA; GF; germ-free; HSV; herpes simplex virus; Ig; immunoglobulin; IL; inte
Keywords: MG; myasthenia gravis; EBV; Epstein-Barr virus; TLR; Toll-like receptor; GC; germinal center; IFN; interferon; AChR; acetylcholine receptor; EBER; EBV-encoded small RNA; LCM; laser-capture microdissection; IRF8; interferon regulatory factor 8; LMP1; Eps
Keywords: AIM2; Absent in Melanoma 2; AOSD; adult-onset Still's disease; AS; ankylosing spondylitis; ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; CAPS; cryopyrin-associated periodic syndrome; CARD; caspase-recruitment domain
Keywords: Clarithromycin (PubChem CID: 84029); poly I:C (PubChem CID: 32744); Pam3CSK4 (PubChem CID: 130704); CAM; clarithromycin; CARD; caspase activation and recruitment domain; CCL5; chemokine (C-C motif) ligand 5; CF; cystic fibrosis; COPD; chronic obstructive
Keywords: ACP5; Acid phosphatase 5; ADAR1; Adenosine deaminase RNA-specific 1; AGS; Aicardi-Goutières syndrome; ALRs; AIM2-like receptors; AIM2; Absent in melanoma 2; ASC; Apoptosis-associated speck-like protein containing a CARD; CANDLE; Chronic atypical neutroph
Keywords: Ubiquitin; RIG-I; STING; Post-translational modification; Innat
Keywords: Influenza viruses; Innate immunity; Interferon; RIG-I;
Keywords: AIM2; absent in melanoma 2; AP-1; activating protein-1; APOBEC; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; AZT; azidothymidine; CCCR5; C-C chemokine receptor type 5; CDK1; cyclin-dependent kinase 1; CXCR4; C-X-C chemokine receptor t
Keywords: Ag; antigen; APC; antigen-presenting cells; AIV; avian influenza virus; BM; bone marrow; BALT; bronchus-associated lymphoid tissue; CG; chicken galectin; cLL; chicken lung lectin; CLR; C-type lectin receptors; DC; dendritic cells; DC-SIGN; DC-specific int
Keywords: RIG-I; pathway; TLR8; Lymph node; Duck; Chicken; Major Histocompatibility Complex;
Positive regulatory role of c-Src-mediated TRIM25 tyrosine phosphorylation on RIG-I ubiquitination and RIG-I-mediated antiviral signaling pathway
Keywords: RIG-I; TRIM25; Interferon; Tyrosine phosphorylation; c-Src; Ubiquitination;
Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells
Keywords: APCs; antigen presenting cells; BM-DCs; bone marrow-derived DCs; DCs; dendritic cells; DAMPs; danger associated molecular patterns; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence-activated cell sorting; GAPDH; glyceraldehyde-3-phosphate dehy
Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases
Keywords: ARS; aminoacyl-tRNA synthetase; TLR; toll-like receptor; RIG-I; retinoic acid-inducible gene-I; MAVS; mitochondrial antiviral signaling protein; IFN; interferon; ITCH; E3 ubiquitin-protein ligase Itchy homolog; MSC; multi-tRNA synthetase complex; AIMP; AR
The mechanisms of Ag85A DNA vaccine activates RNA sensors through new signal transduction
Keywords: DC; dendrite cells; BMDCs; bone-marrow dendrite cells; APC; antigen presenting cell; PRR; pattern recognition receptor; PAMPs; pathogen-associated molecular patterns; RIG-I; retinoic acid-inducible gene I; Mda-5; melanoma differentiation associated gene-5
The role of type I interferons in innate and adaptive immunity against viruses in Atlantic salmon
Keywords: Adjuvant; DNA vaccine; Fish; IFN; ISG; TLR; CRFB; class II cytokine receptor family member; HE; hemagglutininesterase; IFN; interferon; IFN-I; type I IFN; IFNAR; mammalian type I IFN receptor; IPNV; infectious pancreatic necrosis virus; IPS-1; interferon
Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver
Keywords: PRR; Virus Immune Evasion; PAMP; Ex Vivo; CHB; chronic hepatitis B; CTRL; uninfected control; dsRNA; double-stranded RNA; HBcAg; HBV core protein; HBeAg; hepatitis B e antigen; HBsAg; HBV surface protein; HBV; hepatitis B virus; IFN; interferon; ISG; in
Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases
Keywords: ALS; amyotrophiclateral sclerosis; AP-1; activator protein 1; APC; antigen-presenting cell; APC/C; anaphase promoting complex/cyclosome; CLR; C-type lectin receptor; CRL; Cullin RING ligase; ERK; extracellular signalregulated kinase; FANC; Fanconi anemia
Rig-I is involved in inflammation through the IPS-1/TRAF6 pathway in astrocytes under chemical hypoxia
Keywords: RIG-I; retinoic acid-inducible gene I; IPS-1; interferon-β promoter stimulator-1; TRAF; TNF receptor-associated factor; PRRs; pattern recognition receptors; TLRs; toll-like receptors; NLRs; NOD-like receptors; RLRs; RIG-like receptors; MDA5; melanoma dif
Identification of a novel porcine OASL variant exhibiting antiviral activity
Keywords: JEV; Japanese encephalitis virus; IFNs; interferons; ISGs; IFN-stimulated genes; OAS; 2',5'-oligoadenylate synthetase; PRRs; pattern-recognition receptors; RNase L; ribonuclease L; RIG-I; retinoic acid-inducible gene I; MDA5; melanoma differentiation-
Regulation and biological roles of the multifaceted miRNA-23b (MIR23B)
Keywords: miRNAs; MicroRNAs; C9orf3; Chromosome 9 Open Reading Frame 3; pri-miRNAs; primary miRNA; pre-miRNAs; precursor miRNAs; miRISC; miRNA-induced silencing complex; ECs; endothelial cells; VSMCs; vascular smooth muscle cells; ACTA2; smooth muscle α-actin; MYH
Lethal influenza A virus preferentially activates TLR3 and triggers a severe inflammatory response
Keywords: Lethal avian influenza A virus; TLR3; RIG-I; Inflammatory response;
Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; NS; nonstructural protein; TIR; toll/interleukin 1 receptor; TRIF; (TIR)-domain-containing adapter-inducing interferon-β; IIR; innate immune response; RIG-I; retinoic acid inducible gene; MAVS; mitoc
Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations: AÂ randomized controlled study
Keywords: Asthma; viral infection; inflammation; Toll-like receptor 3; ACQ7; Asthma Control Questionnaire 7; AE; Adverse event; AUC; Area under the curve; CCSS; Cold and Chest Symptom Scale; CSAS; Cold Symptom Assessment Score; Feno; Fraction of exhaled nitric oxid
Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes
Keywords: Exosomes; Escape; Virology; Rab27a; DMV; double-membrane vesicle; dsRNA; double-stranded RNA; EVs; extracellular vesicles; gt; genotype; HAV; hepatitis A virus; HCV; hepatitis C virus; HCVcc; cell culture derived HCV; IFIT1 or 3; interferon-induced protei
HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon
Keywords: Coinfection; Interferon-stimulated Gene; PRR; RIG-I; APOBEC; apolipoprotein B mRNA editing enzyme catalytic subunit; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; circDNA; circular DNA; GFP-IRF3; green fluorescent protein-interferon
Human microglia and astrocytes express cGAS-STING viral sensing components
Keywords: AMP; adenosine monophosphate; ATCC; American type tissue collection; ANOVA; analysis of variance; BDNA; B-form DNA; CNS; central nervous system; cDNA; complementary DNA; cGAS; cyclic GMP-AMP synthase; DAI; DNA-dependent activator of interferon-regulatory
5â²-Triphosphate siRNA targeting MDR1 reverses multi-drug resistance and activates RIG-I-induced immune-stimulatory and apoptotic effects against human myeloid leukaemia cells
Keywords: siRNA; RIG-I; DDX58; MDR1; CXCL10; leukaemia; apoptosis;
Research reportInterferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid
Keywords: IFN; interferon; IFI; IFN-induced protein; ISG; IFN-stimulated gene; poly IC; polyinosinic-polycytidylic acid; RIG-I; retinoic acid-inducible gene-I; TLR3; Toll-like receptor 3; STAT1; signal transducer and activator of transcription 1; Astrocytes; TLR3;
4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell
Keywords: 4(3H)-Quinazolone; Innate immune signal; RIG-I; Respiratory syncytial virus;
Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells
Keywords: HCV; Innate immunity; RIG-I; Interferon; Human iPS cells;
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cells
Keywords: IFNγ; interferon gamma; RIG-I; retinoic acid (RA)-inducible gene-I; SFM; serum free media; ChIP; chromatin immunoprecipitation; NFκB; nuclear factor kappa B; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; PRMT-1; protein
Original ArticleRole of cellular metabolism in regulating type I interferon responses: Implications for tumour immunology and treatment
Keywords: Type I interferons; Immunometabolism; Antiviral immune responses; Inflammation; Cancer; IFN; interferon; ISG; interferon stimulated genes; PD-L1; program death-ligand 1; TLR; Toll-like receptor; RIG; retinoic acid-inducible gene-like helicases; RLR; RIG-I
CK2 induced RIG-I drives metabolic adaptations in IFNγ-treated glioma cells
Keywords: IFNγ; interferon gamma; RIG-I; retinoic acid (RA)-inducible gene-I; CK2; casein kinase 2; SFM; serum free media; TIGAR; TP53 induced glycolysis and apoptosis regulator; G6PD; glucose 6 phosphate dehydrogenase; DCFDA; dichlorodihydrofluorescein diacetate;
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
Early gene activation initiates neuroinflammation prior to VSV neuroinvasion: Impact on antiviral responses and sleep
Keywords: REM sleep; rapid eye movement; NREM sleep; non-rapid eye movement sleep; IFN-I; type I interferon; PI; post infection; TLRs; Toll like receptors; RIG-I; retinoic acid inducible gene-I; ICV; intracerebroventricular; NLRP3; nucleotide-binding oligomerizatio
Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure
Keywords: IFN I; type I interferon(s); IFI16; interferon-inducible protein 16; cGAMP; cyclic GMP-AMP; cGAS; cGAMP synthase; STING; stimulator of interferon genes; TBK1; TANK-binding kinase 1; IRF3; interferon regulatory factor 3; ISG; interferon-stimulated genes; P
The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy
Keywords: 5â²PP; 5â²-diphosphate; 5â²ppp; 5â²triphosphorylated; Bcl2; B-cell lymphoma-2; BIRC3; baculoviral IAP repeat-containing 3; CARDs; caspase activation and recruitment domains; CRC; colorectal cancer; CTD; C-terminal domain; CTLs; cytotoxic T lymphocytes
Molecular cloning, characterization, and expression of duck 2â²-5â²-oligoadenylate synthetase-like gene
Keywords: OASs; 2â²-5â²-oligoadenylate synthetases; OASL; 2â²-5â²-Oligoadenylate synthetase-like protein; duOASL; duck 2â²-5â²-oligoadenylate synthetase-like protein; DTMUV; Duck Tembusu virus; NTase; nucleotidyltransferase; UBL; ubiquitin-like; IFN; interfer
Zebrafish STAT6 negatively regulates IFNÏ1 production by attenuating the kinase activity of TANK-binding kinase 1
Keywords: STAT6; Negative regulator; Interferon; TBK1; Zebrafish; CIP; calf intestinal phosphatase; CPE; cytopathic effect; EPC; epithelioma papulosum cyprini; GAS; interferon gamma activated sequence; IFN; interferon; IRF; IFN regulatory factor; IRF3; interferon r
Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells
Keywords: 7-AAD; 7-aminoactinomycin-D; AMA; Antimycin-A; IFN; interferon; IRF; interferon regulatory factor; MAVS; mitochondrial antiviral-signaling; mtROS; mitochondrial reactive oxygen species; pDCs; plasmacytoid dendritic cells; PI3K; phosphatidylinositol-3-kina
Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism
Keywords: Influenza A virus; Duox2; RIG-I; MDA5; Acute viral lung infection;