دانلود مقالات ISI درباره S-Adenosyl-L-Homocysteine + ترجمه فارسی

درمان سرطان ریه با هدف متدی سازی هیستون: فرصت ها و چالش ها

Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges

Keywords: Histone methylation; Histone demethylation; Lung cancer; Histone methyltransferase; Histone demethylase; Inhibitors; ALK; anaplastic lymphoma kinase; DUSP3; dual-specificity phosphatase 3; Elk1; ETS-domain containing protein; EMT; epithelial-to-mesenchyma

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

ابزارهای جدید در جعبه ابزارهای نوکلئوزید مهار کننده های تولید انسانی ویروس آنفولانتیک تلقی شده

New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors

Keywords: 7DCMA; 7-deaza-2′-C-methyladenosine; DENV; dengue virus; EV-A71; enterovirus A71; MTase; methyltransferase; NS5; non-structural protein 5; RAFI; rigid amphipathic fusion inhibitor; RdRp; RNA-dependent RNA polymerase; SAH; S-adenosyl-l-homocysteine; TBEV

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

بینش عملکردی از ساختارهای با وضوح بالا از پروتئین موسیر آرژینین متیل ترانسفراز 6

Functional insights from high resolution structures of mouse protein arginine methyltransferase 6

Keywords: PRMT; protein arginine methyltransferase; SAM; S-adenosyl-l-methionine; SAH; S-adenosyl-l-homocysteine; SFG; sinefungin; PDB; Protein Data Bank; rmsd; root square mean deviation; ESI-MS; electrospray ionization mass spectrometry; LC-MS/MS; liquid chroma

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

اثرات ژنوتوکسیک، اپیزیونیک و ترانسکتومیک تاموکسیفن در کبد موش

Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver

Keywords: NAFLD; Non-alcoholic fatty liver disease; dG-TAM; (E)-α-(deoxyguanosin-N2-yl)-tamoxifen; dG-DesMeTAM; (E)-α-(deoxyguanosin-N2-yl)-N-desmethyltamoxifen; ALT; alanine transaminase; AST; aspartate transaminase; LDH; lactate dehydrogenase; α-SMA; α-smooth

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

ارزیابی هلیکاز ویروس دنگی و متیل ترانسفراز به عنوان هدف برای کشف مواد مخدر مبتنی بر قطعه

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

Keywords: DENV; Dengue virus; NS; non-structural protein; MTase; methyltransferase; Hel; helicase; AdoMet; S-adenosyl-l-methionine; AdoHcy; S-adenosyl-l-homocysteine; FBDD; fragment-based drug discovery; FBS; fragment-based screening; FBS-X; FBS by X-ray crystallog

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

یک جهش فعال در محل پروتئین اسید چرب اشرشیا کولی، سیکلوپروپان اسید چرب باعث ایجاد اسیدهای چرب غیر طبیعی می شود که از بین می رود. مکانیسم واکنش آنزیمی

An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction

Keywords: Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; Fatty acid methyl ester; Enzyme mechanism; AdoHcy; S-adenosyl-l-homocysteine; AdoMet; S-adenosyl-l-methionine; CS; cyclopropane synthase; CFAS; cyclopropane fatty acid synthase; CMAS; cyclo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

تغییرات اپیگنتیک توسط فیتوشیمیایی جیره: پیامدهای تغذیه فردی

Epigenetic modifications by dietary phytochemicals: Implications for personalized nutrition

Keywords: Epigenetics; Phytochemicals; DNA-methylation; Histone-modification; miRNA; Carcinogenesis; Akt; v-akt murine thymoma viral oncogene homolog 1; AP-1; Activator Protein-1; Bax; BCL2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; Bcl-xL; B-cell lymphoma-

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2013 سفارش ترجمه

Dynamic regulation of six histone H3 lysine (K) methyltransferases in response to prolonged anoxia exposure in a freshwater turtle

Keywords: K; lysine; R; arginine; H3K4me1; monomethylated histone H3 lysine 4; H3K27me1; monomethylated histone H3 lysine 27; H3K9me3; trimethylated histone H3 lysine 9; HP1; heterochromatin protein 1; HKMT; histone lysine methyltransferases; SAM; S-adenosyl-L-meth

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

An asymmetric dimeric structure of TrmJ tRNA methyltransferase from Zymomonas mobilis with a flexible C-terminal dimer

Keywords: TrmJ; Methyltransferase; tRNA methylation; CTD; C-terminal domain; EcTrmJ; TrmJ from E. coli; HiTrmJ; TrmJ from H. influenza; NTD; N-terminal domain; rms; root-mean-square; SAH; S-adenosyl-l-homocysteine; SAM; S-adenosyl methionine; Trm; tRNA methyltans

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies

Keywords: DNMT; DNA methyltransferase; 5azadC; 5-aza-2′-deoxycytidine; 5azaC; 5-azacytidine; SAM; S-adenosyl-l-methionine; SAH; S-adenosyl-l-homocysteine; DNMTi; DNMT inhibitors; HDACi; histone deacetylase inhibitors; CpGs; 5′-CpG-3′ dinucleotides; CGis; CpG

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

S-adenosyl-L-homocysteine hydrolase from a hyperthermophile (Thermotoga maritima) is expressed in Escherichia coli in inactive form - Biochemical and structural studies

Keywords: Ado; adenosine; ADP; atomic displacement parameter; AMP; adenosine 5′-monophosphate; Hcy; L-homocysteine; DLS; dynamic light scattering; FPLC; fast protein liquid chromatography; HEPES; (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid); iTmSAHase; in

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

Keywords: Phenyl [(phenylcarbamoyl)amino]benzene-1-sulfonate derivatives; N-Phenyl-[(phenylcarbamoyl)amino]benzene-1-sulfonamide derivatives; Fragment-linking strategy; Dengue virus; NS5 methyltransferase inhibitors; Antiviral activity; DENV; dengue virus; NS; non-

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Crystal structure of Rv2258c from Mycobacterium tuberculosis H37Rv, an S-adenosyl-l-methionine-dependent methyltransferase

Keywords: MTase; methyltransferase; SAM; S-adenosyl-l-methionine; SAH; S-adenosyl-l-homocysteine; SFG; sinefungin; r.m.s.; root mean square; TB; tuberculosis; Rv2258c; Mycobacterium tuberculosis; Small-molecule methyltransferase; Sinefungin; S-adenosyl-l-homocystei

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Crystal structure of pentapeptide-independent chemotaxis receptor methyltransferase (CheR) reveals idiosyncratic structural determinants for receptor recognition

Keywords: MCPRs; methyl-accepting chemotactic protein receptors; SAH; S-adenosyl-l-homocysteine; PICheR; pentapeptide-independent CheR; PDCheR; pentapeptide-dependent CheR; Chemotaxis; Methyltransferase; Methylation; Isothermal titration calorimetry;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics

Keywords: PRMT1; protein arginine methyltransferase 1; MMA; monomethylarginine; ADMA; asymmetric dimethylarginine; SDMA; symmetric dimethylarginine; AdoMet; S-adenosylmethionine; AdoHcy; S-adenosyl-l-homocysteine; GGRGG; Gly-Gly-Arg-Gly-Gly; NAC; near-attack confor

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase

Keywords: H2S; hydrogen sulfide; NO; nitric oxide; CO; carbon monoxide; CcOX; cytochrome c oxidase; CBS; cystathionine β-synthase; AdoMet; S-adenosyl-l-methionine; CGL; cystathionine γ-lyase; PLP; pyridoxal 5′-phosphate; MST; 3-mercaptopyruvate sulfurtransferas

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2016 سفارش ترجمه

Functional roles in S-adenosyl-l-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase

Keywords: Ala; alanine; Arg; arginine; Asn; asparagine; Asp; aspartic acid; ESI-MS; electrospray ionization mass spectrometry; IMAC; immobilized metal ion affinity chromatography; IPTG; isopropyl β-D-1-thiogalactopyranoside; ITC; isothermal titration calorimetry;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Metabolomics of adherent mammalian cells by capillary electrophoresis-mass spectrometry: HT-29 cells as case study

Keywords: CHO; chinese hamster ovary; PBS; phosphate-buffered saline; CE-TOF MS; capillary electrophoresis-time-of-flight mass spectrometry; DFMO; difluoromethylornithine; GABA; γ-aminoisobutyric acid; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium brom

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2015 سفارش ترجمه

Crystal structure and activity of protein L-isoaspartyl-O-methyltransferase from Vibrio cholerae, and the effect of AdoHcy binding

Keywords: AdoHcy binding; Crystal structure; Enzyme activity; Methyltransferase; Protein repair; PIMT; protein L-isoaspartyl-O-methyltransferase; AdoMet; S-adenosylmethionine; AdoHcy; S-adenosyl-L-homocysteine; PEG; polyethylene glycol; DHBS; 3,5-dichloro-2-hydroxy

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2015 سفارش ترجمه

Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats

Keywords: AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; SAXS, small-angle X-ray scatteringProtein arginine methyltransferase; S-adenosyl-l-homocysteine; X-ray crystallography

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Using S-adenosyl-l-homocysteine capture compounds to characterize S-adenosyl-l-methionine and S-adenosyl-l-homocysteine binding proteins

Keywords: Capture compound; Fluorescence anisotropy; S-Adenosyl-l-homocysteine; S-Adenosyl-l-methionine;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Intrauterine growth restriction leads to changes in sulfur amino acid metabolism, but not global DNA methylation, in Yucatan miniature piglets

Keywords: BHMT; betaine-homocysteine methyltransferase; CBS; cystathionine β-synthase; CGL; cystathionine γ-lyase; MAT; methionine adenosyltransferase; MS; methionine synthase; MTHFR; methylenetetrahydrofolate reductase; SAH; S-adenosyl-l-homocysteine; SAM; S-ade

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Isolation and characterization of a gene encoding a S-adenosyl-l-methionine-dependent halide/thiol methyltransferase (HTMT) from the marine diatom Phaeodactylum tricornutum: Biogenic mechanism of CH3I emissions in oceans

Keywords: HMT; halide ion methyltransferase; TMT; thiol methyltransferase; HTMT; halide/thiol methyltransferase; SAM; S-adenosyl-l-methionine; SAH; S-adenosyl-l-homocysteine; DMS; dimethyl sulfide; Phaeodactylum tricornutum; Methyl halides; Methyl iodide; S-Adenosy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of human catechol-O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee

Keywords: 2-OH-E2; 2-hydroxyestradiol; 4-OH-E2; 4-hydroxyestradiol; COMT; catechol-O-methyltransferase; AdoMet; S-adenosyl-l-methionine; AdoHcy; S-adenosyl-l-homocysteine; CAPE; caffeic acid phenethyl ester; Coffee polyphenols; Catechol estrogens; 2-Hydroxyestradio

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Alpha anomer of 5-aza-2′-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

Keywords: GIC50; concentration which causes 50% growth inhibition; hTERT; human telomerase reverse transcriptase; CTCF; CCCTC binding factor; 5-azadCyd; 5-aza-2′-deoxycytidine; 5-azaCyd; 5-azacytidine; HAT; histone acetyltransferase; SAH; S-adenosyl-l-homocystein

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues

Keywords: DNA methyltransferase; S-Adenosyl-l-homocysteine; Activation; Inhibition

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

The complex regulatory function of the ligand-binding domain of the inositol 1,4,5-trisphosphate receptor

Keywords: AHCY; S-adenosyl-l-homocysteine hydrolase; CaBP; Ca2+-binding protein; CaM; calmodulin; ER; endoplasmic reticulum; EVH; Ena/VASP homology; IICR; IP3-induced Ca2+ release; IP3; inositol 1,4,5-trisphosphate receptor; IP3R1; type 1 IP3 receptor; IP3R2; type

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-l-homocysteine hydrolase from Trypanosoma cruzi

Keywords: 2× YT; 2× yeast extract tryptone; Ado; adenosine; AdoHcy; S-adenosyl-l-homocysteine; DTT; dl-Dithiothreitol; EDTA; ethylenediaminetetraacetic acid; FPLC; fast protein liquid chromatography; Hcy; l-homocysteine; HPLC; high performance liquid chromatograp

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Aryltetralin-lignan formation in two different cell suspension cultures of Linum album: Deoxypodophyllotoxin 6-hydroxylase, a key enzyme for the formation of 6-methoxypodophyllotoxin

Keywords: ABT; 1-aminobenzotriazole; CAD; cinnamyl alcohol-dehydrogenase; C4H; cinnamic acid 4-hydroxylase; clot; clotrimazole; cyt c; cytochrome c; DOP (1); deoxypodophyllotoxin; DOP6H; deoxypodophyllotoxin 6-hydroxylase; DOP7H; deoxypodophyllotoxin 7-hydroxylase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Mutational analyses of Plasmodium falciparum and human S-adenosylhomocysteine hydrolases

Keywords: SAH; S-adenosylhomocysteine; SAHH; S-adenoshylhomocysteine hydrolase; Pf; Plasmodium falciparum; Hs; Homo sapiens; NAM; noraristeromycin; 2FNAM; 2-Fluoro noraristeromycin; S-adenosyl-l-homocysteine; Plasmodium falciparum; Site-directed mutagenesis; Nucleo

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: Structure-activity relationship and molecular-modeling studies

Keywords: EGCG; (-)-epigallocatechin-3-gallate; ECG; (-)-epicatechin-3-gallate; EGC; (-)-epigallocatechin; EC; (-)-epicatechin; EGCG-7-Gluc; (-)-EGCG-7-O-glucuronide (and similar abbreviations for other glucuronidates); 4′-MeEGC; 4′-O-methyl-EGC; 4″

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Expression and activity of l-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors

Keywords: Disorders of the nervous system; Neuro-oncology; AdoHcy; S-adenosyl-l-homocysteine; AdoMet; S-adenosyl-l-methionine; BSA; bovine serum albumin; DSIP-isoD; delta-sleep-inducing peptide; ECL; enhanced chemiluminescence; GAPDH; glyceraldehyde-3-phosphate deh

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active

Keywords: AdoHcy; S-adenosyl-l-homocysteine; AdoMet; S-adenosyl-l-methionine; βME; β-mercaptoethanol; AUC; analytical ultracentrifugation; DTT; dithiothreitol; EDTA; ethylene-diamine tetraacetic acid; GSH; reduced glutathione; GSSG; oxidized glutathione; PAGE; po

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه