Aryltetralin-lignan formation in two different cell suspension cultures of Linum album: Deoxypodophyllotoxin 6-hydroxylase, a key enzyme for the formation of 6-methoxypodophyllotoxin

Suspension cultures initiated from two different Linum album seedlings accumulate either podophyllotoxin or 6-methoxypodophyllotoxin as main lignans due to the different activity of the enzyme deoxypodophyllotin 6-hydroxylase. Data about the enzyme activity during a subculture period on the enzyme characteristics as well as concerning the biosynthetic pathway are discussed.