Keywords: هفت ترامبنر; mast cells; degranulation; Mas-related G protein-coupled receptor X2; IL-33; adhesion G protein-coupled receptor E2; tryptase; allergy; mastocytosis; ADGRE2; Adhesion G protein-coupled receptor E2; CPA3; Carboxypeptidase 3; CTMC; Connective tissue m
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Signaling via G proteins mediates tumorigenic effects of GPR87
Keywords: هفت ترامبنر; 7TM; seven transmembrane; AC; adenylate cyclase; BSA; bovine serum albumin; cAMP; cyclic adenosine monophosphate; CREB; cAMP response element-binding protein; CSC; cancer stem cells; CysLTs; cysteinyl-leukotrienes; ELISA; Enzyme-linked immunosorbent assay
GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα12/13/RhoA Signaling
Keywords: هفت ترامبنر; aGPCR; adhesion G protein-coupled receptor; CTF; C-terminal fragment; GPCR; G protein-coupled receptor; GPR56; G protein-coupled receptor 56; GPS; GPCR proteolysis site; mAb; monoclonal antibody; NTF; N-terminal fragment; 7TM; seven transmembrane; WT; wi
Molecular insights into allosteric modulation of Class C G protein-coupled receptors
Keywords: هفت ترامبنر; GABAB; γ-aminobutyric acid receptor B; BMD; bone mass and density; CaSR; calcium-sensing receptor; CHO; Chinese hamster ovary; CRD; cysteine-rich domain; ER; endoplasmic reticulum; Ca2+o; extracellular calcium; pERK1/2; extracellular signal-regulated kin
A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain
Keywords: هفت ترامبنر; GPCR; G-protein-coupled receptor; Hx8; Helix-8; TM7; seven transmembrane; GPCR signaling; GPCR-PDZ interaction; Biased molecular dynamics; Steered molecular dynamics simulation; Palmitoylation and depalmitoylation; Membrane insertion GPCR-membrane int
The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration
Keywords: هفت ترامبنر; 7TM; seven transmembrane; ADGR; adhesion G protein-coupled receptor; ADGRG2; adhesion G protein-coupled receptor subfamily G member 2; DNM2; dynamin 2; GAIN; GPCR Autoproteolysis Inducing; GPCR; G protein-coupled receptor; GPS; GPCR Proteolytic Site; GSHR
N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization
Keywords: هفت ترامبنر; BSA; bovine serum albumin; CRD; cysteine-rich domain; dFBS; dialyzed fetal bovine serum; DPBS; Dulbecco's Phosphate-Buffered Saline; DTT; dithiothreitol; ECD; extracellular domain; ELISA; Enzyme-Linked Immunosorbent Assay; ER; endoplasmic reticulum; EtO
Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands
Keywords: هفت ترامبنر; 7-TM; seven transmembrane; A2AR; adenosine A2A receptor; A3R; adenosine A3 receptor; BSA; bovine serum albumin; cAMP; cyclic adenosine-5â²-monophosphate; CHO; Chinese Hamster Ovary; CHOhLHr_luc; human LH receptor and luciferase reporter gene transfected