کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8712901 | 1587100 | 2018 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mast cells signal their importance in health and disease
ترجمه فارسی عنوان
سلول های مشتق از اهمیت خود در سلامت و بیماری ها خبر می دهند
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کلمات کلیدی
GPCRMCTCCPA3TregIL-33mastocytosisSCF7TMTLRCTMCMCTST2LMRGPRX2PD-L1MMCPD-1STAT3G protein–coupled receptor - G گیرنده پروتئینی همراه استsST2 - SST2Allergy - آلِرژیTryptase - تریپتازToll-like receptor - تیالآرConnective tissue mast cell - سلول مشتق شده بافت اتصالMucosal mast cell - سلول های مزانشیمی مخاطیStem Cell Factor - فاکتور سلول بنیادیDegranulation - قرمزی چشمprogrammed cell death ligand 1 - لیگاند مرگ سلولی برنامه ریزی شده 1Mast cells - ماست سل هاsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3Regulatory T - مقررات Tseven transmembrane - هفت ترامبنرprogrammed cell death protein 1 - پروتئین مرگ سلولی برنامه ریزی شده 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
FcεRI is the primary receptor in mast cells that mediates allergic reactions by inducing rapid release of mediators, an adaptive immune response that might have evolved as a host defense against parasites and venoms. Yet it is apparent that mast cells are also activated through non-IgE receptors, the significance of which is just beginning to be understood. This includes the Mas-related G protein-coupled receptor X2, which might contribute to reactions to diverse antimicrobials and polybasic compounds, and the adhesion G protein-coupled receptor E2, variants of which are associated with familial vibratory urticaria and are activated by mechanical vibration. Similarly, mast cells have long been recognized as the main repository for histamine, heparin, and proteases. Recent evidence also points to new functions, modes of delivery, and mechanisms of action of mast cell proteases that add new dimensions to the roles of mast cells in human biology. In addition, exposure of mast cells to environmental cues can quantitatively and qualitatively modulate their responses and thus their effect on allergic inflammation. Illustrating this paradigm, we summarize a number of recent studies implicating the injury/tissue damage cytokine IL-33 as a modulator of allergen-induced mast cell responses. We also discuss the discovery of markers associated with transformed mast cells and new potential directions in suppressing mast cell activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 142, Issue 2, August 2018, Pages 381-393
Journal: Journal of Allergy and Clinical Immunology - Volume 142, Issue 2, August 2018, Pages 381-393
نویسندگان
Ana PhD, Michael A. PhD, Dean D. MD,