The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression
Keywords: MYB; Leukemia; Apoptosis; shRNA; DRAK2/STK17B;
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MAP kinase phosphatase-3 (MKP-3) is transcriptionally and post-translationally up-regulated by hCG and modulates cAMP-induced p21 expression in MA-10 Leydig cells
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole; DUSPs; dual specificity phosphatases; FGF; fibroblast growth factor; FOXO1; Forkhead box protein O1; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GnRH; gonadotropin releasing hormone; L19; ribosomal L19 protein;
p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells
Keywords: DH; Dbl homology; FCS; fetal calf serum; GEF; guanine nucleotide exchange factor; GST; glutathione S-transferase; PH; pleckstrin homology; RBD; Rho-binding domain; shRNA; short hairpin RNA; p63RhoGEF; RhoA; Rho-GEF; Cell migration; Lamellipodium; MDA-MB-2
Research ArticleActivated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion
Keywords: HSC; hepatic stellate cell; IFN; interferon; MDSC; myeloid derived suppressor cell; PGE2; prostaglandin E2; SCF; stem cell factor; siRNA; small interfering RNA; shRNA; small hairpin RNA; VEGF; vascular endothelial growth factor; Hepatic stellate cell; Mye
Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence
Keywords: OIS; oncogene-induced senescence; MEF; mouse embryonic fibroblast; ERK; extracellular signal-regulated kinase; MEK; mitogen-activated protein kinase kinase; PI3K; phosphatidylinositol 3-kinase; pRb; retinoblastoma tumor suppressor protein; SA-β-Gal; sene
FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway
Keywords: ANOVA; analysis of variance; bFGF; basic fibroblast growth factor; CsA; cyclosporin A; DMSO; dimethylsulfoxide; EGF; epidermal growth factor; eNOS; endothelial nitrogen oxide synthase; ERK; extracellular-regulated kinase; FKBP; FK506-binding protein; GAPD
HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain
Keywords: ALLN; N-acetyl-leucyl-leucyl-norleucinal; Brk; breast tumor kinase; CHX; cycloheximide; DMEM; Dulbecco's modified Eagle's medium; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Erk; extracellular signal-regulated kinase; FAK;
Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells
Keywords: BSA; bovine serum albumin; CMV; cytomegalovirus; DAPI; 4,6-diamidio-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; Dox; doxycycline; EBs; embryoid bodies; ES-FCS; ES-qualified fetal calf serum; Fndc5; fibronectin type III domain-containing
Proteomic-based identification of Apg-2 as a therapeutic target for chronic myeloid leukemia
Keywords: Chronic myeloid leukemia; BCR/ABL; H2O2; Apg-2; Proteomic; shRNA;
Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells
Keywords: TSA; Trichostatin A; HCC; hepatocellular carcinoma; lncRNA; long non-coding RNA; qRT-PCR; real-time quantitative reverse transcription PCR; HDAC; histone deacetylases; HDACi; histone deacetylase inhibitors; TUNEL; Terminal deoxynucleotidyltransferasedUTP
Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localization
Keywords: TG2; transglutaminase 2; HIF; hypoxia inducible factor; HRE; hypoxia response element; XRE; xenobiotic response element; OGD; oxygen glucose deprivation; NLS; nuclear localization signal; NES; nuclear export signal; CAT; catalytic; ChIP; chromatin immunop
The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles
Keywords: Metastasis; Bioreducible polymer; shRNA; Nanoparticles; Breast cancer;
Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK
Keywords: ADAM; a disintegrin and metalloproteinase domain; AP-1; activator protein-1; ARB; angiotensin receptor blockers; AT1; angiotensin II type 1 receptor; AT2; angiotensin II type II receptor; CF; cardiac fibroblasts; CMV; cytomegalovirus; CVD; cardiovascular
Research reportContribution of Rag1 to spatial memory ability in rats
Keywords: Recombination activating gene1; shRNA; Lentivirus; Hippocampus; RT-PCR; Morris water maze; Long-term potentiation;
3,3â²-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction
Keywords: AhR; aryl hydrocarbon receptor; CCK-8; Cell Counting Kit-8; DAI; disease activity index; DIM; 3,3â²-diindolylmethane; DSS; dextran sodium sulfate; EAE; experimental autoimmune encephalomyelitis; ERα; estrogen receptor α; FICZ; 6-formylindolo[3,2-b]carb
Regenerative Nanomedicine for Vision Restoration
Keywords: AAQ; acrylamide-azobenzene-quaternary ammonium; ChR2; channelrhodopsin-2; CNV; choroidal new vessel; ECM; extracellular matrix; GDNF; glial cell line-derived neurotrophic factor; HaloR; halorhodopsin; IOP; intraocular pressure; PCL; poly(ε-caprolactone
A Gene Expression Signature of Epithelial Tubulogenesis and a Role for ASPM in Pancreatic Tumor Progression
Keywords: Pancreatic Cancer; Tumor Progression; Prognostic Factor; Biomarker; ASPM; abnormal spindle-like microcephaly associated; C-index; concordance index; CSC; cancer stem cell; 3D; 3-dimensional; Dvl; dishevelled; HPDE; human pancreatic ductal epithelial; PDAC
Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids
Keywords: APL; acute promyelocytic leukaemia; As2O3; arsenic trioxide; CatL; Cathepsin L; Bax; BCL2-associated X protein; Bcl2; B-cell CLL/lymphoma2; ECM; extracellular matrix; GBM; glioblastoma multiforme; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxypheny
Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP)
Keywords: 3â²-UTR; 3â²-untranslated region; 5â²-UTR; 5â²-untranslated region; AUF1; AU-rich element RNA binding protein 1; ARE; AU-rich element; ARE-BP; ARE binding protein; β2M; β2-microglobulin; β-tub.; β-tubulin; cds; coding sequence; CM; cytokine mixtur
CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction
Keywords: Act1; activator of NF-κB; AOPPs; advanced oxidation protein products; AGE; advanced glycation end product; AP-1; activator protein-1; C/EBP; CCAAT/enhancer-binding protein; CIKS; connection to IKK and SAPK/JNK; DCFH-DA; 2â²,7â²-dichlorofluorescin-diace
Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19
Keywords: 2D; two-dimensional; ABC; avidin-biotin complex; ACN; acetonitrile; AFP; alpha-fetoprotein; BAP1; BRCA1-associated protein-1; BCLC; Barcelona Clinic Liver Cancer; co-IP; co-immunoprecipitation; CT; computed tomography; DAB; diaminobenzidine; DDR; DNA da
Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events
Keywords: iPS cells; induced pluripotent stem cells; hiPS-C4; hiPS cell line UC C0406 iPS-C4; ES cells; embryonic stem cells; NPCs; neural progenitor cells; CCEs; cell cycle events; Aβ; β-amyloid; NFTs; neurofibrillary tangles; APP; amyloid precursor protein; AD;
Targeting long non-coding RNAs in cancers: Progress and prospects
Keywords: ANRIL; antisense non-coding RNA in the INK4 locus; ATRA; all-trans retinoic acid; ASO; antisense oligonucleotide; CRC; colorectal carcinoma; CREB; cAMP-responsive element binding protein; DM1; myotonic dystrophy type 1; DsRNA; double-stranded RNA; EMT; ep
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4
Keywords: F-actin; filamentous actin; G-actin; globular actin; LIMK; LIM domain kinase; LRRK2; leucine-rich repeat kinase 2; PAK; p21 protein (Cdc42/Rac)-activated kinase; qRT-PCR; quantitative reverse transcription polymerase chain reaction; GEF; guanine nucleotid
RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells
Keywords: 6-OHDA; 6-Hydroxydopamine; AAV; adeno-associated virus; AD; Alzheimer's disease; ANOVA; analysis of variance; AP; anteroposterior; BDNF; brain-derived neurotrophic factor; CD200; cluster of differentiation 200; DLB; dementia with Lewy bodies; DV; dorsoven
Multifunctional protein APPL2 contributes to survival of human glioma cells
Keywords: Tumor cell biology; Apoptosis; Gene expression; Endocytosis; APPL proteins; HRK; GBM; glioblastoma; NuRD; nucleosome remodeling and deacetylase; RNAi; RNA interference; RTK; receptor tyrosine kinase; siRNA; small interfering RNA; shRNA; short hairpin RNA;
A Genetic Screen Identifies Interferon-α Effector Genes Required to Suppress Hepatitis C Virus Replication
Keywords: Treatment; Gene Regulation; Virology; Mechanism; ALG10; asparagine-linked glycosylation 10 homolog (yeast, α-1,2-glucosyltransferase); DENV; dengue virus; DPP4; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); HCV; hepatitis C vir
CD44 Is Involved in Mineralization of Dental Pulp Cells
Keywords: CD44; dental pulp; mineralization; odontoblast; shRNA
A possible strategy to produce pigs resistant to porcine reproductive and respiratory syndrome virus
Keywords: Pig; Embryos; shRNA; PRRSV; SCNT; TSA
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells
Keywords: Insulinoma cells; shRNA; Pyruvate carboxylase; Fatty acid synthase; Phospholipids; Cholesterol esters; Lipid remodeling
Organic small hairpin RNAs (OshR): A do-it-yourself platform for transgene-based gene silencing
Keywords: RNA interference; shRNA; Gene silencing;
Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA
Keywords: Osteosarcoma; p53; shRNA; Osteoblastic subtype
Human T Cell Leukemia Virus Type I Tax-Induced IκB-ζ Modulates Tax-Dependent and Tax-Independent Gene Expression in T Cells
Keywords: Abs; antibodies; AP-1; activator protein 1; ATL; adult T cell leukemia; Bcl3; B cell CLL/lymphoma 3; CBB; Coomassie brilliant blue; CREB; cyclic adenosine 3â²,5â²-monophosphate response element-binding protein; EGFP; enhanced green fluorescent protein;
SPOCK1 Is Regulated by CHD1L and Blocks Apoptosis and Promotes HCC Cell Invasiveness and Metastasis in Mice
Keywords: Liver Cancer; Tumor Progression; Gene Regulation; Signal Transduction; AJCC; American Joint Committee on Cancer; BAD; BCL2-associated agonist of cell death; bp; base pair; cDNA; complementary DNA; CHD1L; chromodomain helicase/adenosine triphosphatase DNA
Enhancer of Zeste Homolog 2 Silences MicroRNA-218 in Human Pancreatic Ductal Adenocarcinoma Cells by Inducing Formation of Heterochromatin
Keywords: Pancreatic Cancer; Gene Regulation; Epigenetic; Messenger RNA Processing; 3â²-UTR; 3â²-untranslated region; 5AZAC; 5-azacytidine; DNMT; DNA methyltransferase; DZnep; 3-deazaneplanocin A; EZH2; enhancer of zeste 2 homolog; H3K27me3; histone 3 lysine 27 t
Expression of Intercellular Adhesion Molecule 1 by Hepatocellular Carcinoma Stem Cells and Circulating Tumor Cells
Keywords: Mouse Model; Liver Cancer; Cell-Surface Protein; Cell Migration; AFP; α-fetoprotein; ChIP; chromatin immunoprecipitation; CSC; cancer stem cell; CTC; circulating tumor cell; HCC; hepatocellular carcinoma; ICAM-1; intercellular adhesion molecule 1; K19; c
Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection
Keywords: PBMC; Microarray Analysis; Therapeutic Efficacy; Drug; EVR; early virologic responder; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IFITM1; interferon-induced transmembrane 1; IFN; interferon; ISG; interferon-stimulated gene; NR; nonresponder; OAS; ol
Inhibition of porcine hemagglutinating encephalomyelitis virus replication by short hairpin RNAs targeting of the nucleocapsid gene in a porcine kidney cell line
Keywords: PHEV; shRNA; N gene; Inhibition;
Prostaglandin E2 promotes the nuclear accumulation of lymphoid enhancer factor-1 in poorly differentiated breast cancer cells
Keywords: APC; adenomatous polyposis coli; CK; casein kinase; COX; cyclooxygenase; FAP; familial adenomatous polyposis; FBS; fetal bovine serum; GSK; glycogen synthase kinase; IL; interleukin; LEF; lymphoid enhancer factor; PGE; prostaglandin; PBS; phosphate buffer
The effects of transformation and ZnT-1 silencing on zinc homeostasis in cultured cells
Keywords: Zinc; ZnT-1; shRNA; Transformation; Zinc retention; 65Zn; Hepatocytes, Cultured cells
The critical role of myostatin in differentiation of sheep myoblasts
Keywords: Myostatin; Myoblast; shRNA; Differentiation; Sheep
Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages
Keywords: BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid acetoxymethyl ester; BzATP; 2â²- & 3â²-O-(4-benzoyl) benzoyl-ATP; [Ca2+]i; cytosolic Ca2+ concentration; EtBr; ethidium bromide; ERK; extracellular signal-regulated kinase; LDH; lactate de
Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture
Keywords: mAb; monoclonal antibody; IgG; immunoglobulin G; CHO; Chinese hamster ovary; TXN1; thioredoxin 1; TXN2; thioredoxin 2; GLRX; glutaredoxin; NT; non-targeting gene; NADPH; nicotinamide adenine dinucleotide phosphate; shRNA; short-hairpin RNA; Thioredoxin; D
Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1
Keywords: Chlamydophila (Chlamydia) pneumoniae; VSMC; Cell adhesion; Cell migration; IQGAP1; ShRNA;
Reduction of Liver Ischemia Reperfusion Injury by Silencing of TNF-α Gene with shRNA
Keywords: ischemia reperfusion injury; TNF-α; shRNA; animal model
Survivin Knockdown Enhances Gastric Cancer Cell Sensitivity to Radiation and Chemotherapy In Vitro and in Nude Mice
Keywords: Survivin; shRNA; Gastric cancer; Radiation; Chemotherapy;
shRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis
Keywords: Bmi-1; shRNA; Lung adenocarcinoma; Metastasis; Migration; Inhibit
Intra-accumbal administration of shRNAs against CART peptides cause increases in body weight and cocaine-induced locomotor activity in rats
Keywords: CART; CART peptide; Cocaine; shRNA; Locomotor activity; Nucleus accumbens; Body weight;
Intratracheal administration of p38α short-hairpin RNA plasmid ameliorates lung ischemia-reperfusion injury in rats
Keywords: p38α MAPK; shRNA; ischemia-reperfusion injury; lung injury in rats;
Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line
Keywords: Insulin secretion; Insulin gene transcription; Insulinoma INS-1 832/13 cells; Gene knockdown; shRNA; siRNA; Phospholipids; Sphingosine-1-phosphate (S1P); Sphingosine kinase (SphK); Sphingosine; Ceramide