Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events

► Generation of enriched functional forebrain neurons from human iPS cells ► Modeling Alzheimer's disease by demonstration of Aβ toxicity to human iPS neurons ► Performing a high-throughput screen for compounds blocking Aβ toxicity ► Validation of Cdk2 as a target for blocking Aβ toxic effects