دانلود مقالات ISI درباره Shrna + ترجمه فارسی

[18F]-fluoroestradiol quantitative PET imaging to differentiate ER+ and ERα-knockdown breast tumors in mice

Keywords: Small animal PET; Estrogen receptor; FES; Breast cancer; shRNA;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The BRCA1 alternative splicing variant Δ14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells

Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; AURKA; Aurora kinase A; BC; breast cancer; BRCA1/2; breast cancer-associated gene 1/2; BRCT; BRCA1 C-terminal domain; B2M; beta-2-microglobulin; Cdk2; cyclin-dependent kinase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin

Keywords: GPR; G protein-coupled receptor; WSN; warm sensitive neurons; POA; preoptic area; CBT; core body temperature; shRNAs; short-hairpin RNAs; GIR; glucocorticoid-induced receptor; Treg; regulatory T cells.; Lentivirus; RNAi; shRNA; Knockdown; Warm sensitive n

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleA hedgehog survival pathway in 'undead' lipotoxic hepatocytes

Keywords: NASH; non-alcoholic steatohepatitis; SHH; sonic hedgehog; FFA; free fatty acids; PA; palmitate; LPC; lysophosphatidylcholine; JNK; c-Jun N-terminal kinase; shRNA; short-hairpin RNA; MPH; mouse primary hepatocytes; DAPI; 4′,6-diamidine-2'-phenylindole

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Down-regulation of viral replication by lentiviral-mediated expression of short-hairpin RNAs against vesicular stomatitis virus ribonuclear complex genes

Keywords: VSV; shRNA; Lentivirus; Nucleocapsid; RNAi; Ribonuclear complex

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice

Keywords: Pancreas; Mechanisms; Mouse Model; Tumor; AM; adrenomedullin; CHO; Chinese hamster ovary; DM; diabetes mellitus; IPMN; intraductal papillary mucinous neoplasm; PaC; pancreatic cancer; PaCDM; pancreatic cancer-associated diabetes mellitus; PaNIN; pancrea

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway

Keywords: ER; endoplasmic reticulum; ESCRT; endosomal sorting complex required for transport; HCV; hepatitis C virus; HHV-6; human herpes virus-6; HIV; human immunodeficiency virus; ILV; intraluminal vesicle L-domain, late-domain; MVB; multivesicular body; shRNA; s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: A dominant role for Smad-2

Keywords: AcLDL; acetylated low density lipoprotein; ABCA-1; ATP-binding cassette transporter A-1; ABCG-1; ATP-binding cassette transporter G-1; ApoE; apolipoprotein E; ApoE−/−; apolipoprotein E deficient; CD36; cluster of differentiation 36; DiI; 1,1′-diocta

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Diacylglycerol-containing oleic acid induces increases in [Ca2+]i via TRPC3/6 channels in human T-cells

Keywords: Diacylglycerols; T-cells; Fatty acids; Lipids; Calcium channels; Calcium signaling; TRPC3; TRPC6; shRNA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation

Keywords: NEMO; NF-κB essential modulator; siRNA; small interfering RNA; TCR; T cell receptor; CBM; CARMA1-Bcl10-MALT1 complex; IS; Immunological synapse; shRNA; short hairpin RNA; SM; Soluble membrane; DI; Detergent Insoluble cytoskeleton fraction; AICD; activati

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Silencing of ICERs (Inducible cAMP Early Repressors) results in partial protection of neurons from programmed cell death

Keywords: CREB; ICER; cAMP; shRNA; Apoptosis; p-CREB

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Enhanced antiproliferative effects of combination hexokinase II shRNA and NIS gene therapy on vascular smooth muscle cells

Keywords: Sodium iodide symporter; 131I; Hexokinase II; shRNA; Combination therapy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells

Keywords: CTC; chelerythrine chloride; GPCR; G protein-coupled receptor; MCP-1; monocyte chemoattractant protein-1; pPaxillin; tyrosine 118 phosphorylated paxillin; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; RS; RS-102895; shRNA; short hairpin RNA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells

Keywords: RV; resveratrol; MOM; mitochondrial outer membrane; STS; staurosporine; FCM; flow cytometry; ΔΨm; mitochondrial membrane potential; shRNA; short hairpin RNA; DsRed and GFP; red and green fluorescent proteins; VDAC2; voltage-dependent anion channel 2; CC

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Hepatocytes That Express Variants of Cyclophilin A Are Resistant to HCV Infection and Replication

Keywords: Cell Culture System; In Vitro Model; Virology; Liver; CypA; cyclophilin A; GFP; green fluorescent protein; HCVcc; cell culture-grown hepatitis C virus; HIV; human immunodeficiency virus; PPIA; peptidyl-prolyl isomerase A; shRNA; small hairpin RNA; SNP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin

Keywords: MSC; Mesenchymal stem cells; HD; Huntington's disease; HTT; huntingtin protein; HTT142; huntingtin fragment containing exon 1 and containing approximately 100 CAG repeats; U87; glioblastoma cell line; SH-SY5Y; neuroblastoma cell line; GFP; enhanced green

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Adenoviral vector expressing short hairpin RNA targeting Wnt2B has an effective antitumour activity against Wnt2B2-overexpressing tumours

Keywords: Wnt2B; shRNA; Adenovirus; Gene therapy; c-Myc; Survivin;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Hepatitis C virus entry: Role of host and viral factors

Keywords: E1, E2; Envelop proteins 1, 2; HCC; Hepatocellular carcinoma; HCV; Hepatitis C virus; CD81; Cluster of differentiation 81; SR-BI; Scavenger receptor class B Type I; LDL-R; Low-density lipoprotein receptor; CLDN 1; Claudin 1; PEG-INF-α; pegylated interfer

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M

Keywords: IL-13; IL-1 receptor-associated kinase M; Toll-like receptor 2; airway epithelial cells; ALI; Air-liquid interface; AP-1; Activator protein 1; BEGM; Bronchial epithelial cell growth medium; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; hBD2; Human β

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

Keywords: NASH; Signal Transduction; Mouse Model, Liver Disease; CB1; cannabinoid receptor-1; ER; endoplasmic reticulum; GTP[γS]; [35S]guanosine 5′-[γ-thio]triphosphate; HFD; high-fat diet; IDE; insulin-degrading enzyme; JNK; c-Jun NH2-terminal kinase 1; PBA; 4

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons

Keywords: Ψm; mitochondrial transmembrane potential; BCA; bicinchoninic acid; DIV; days in vitro; DTT; dithiothreitol; EGTA; ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′,-tetraacetic acid; FCCP; carbonyl cyanide p-trifluoromethoxyphenylhydrazone; GFP; g

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1

Keywords: Primary immunodeficiency; innate immunity; chronic mucocutaneous candidiasis; monocytes; AIRE; Autoimmune regulator; APECED; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy; CARD9; Caspase recruitment domain-containing protein 9; CMC;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Negative regulation of Yap during neuronal differentiation

Keywords: Yap; Helix–loop–helix; Transcription; Retina; Neurogenesis; shRNA

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Reciprocal Activation Between PLK1 and Stat3 Contributes to Survival and Proliferation of Esophageal Cancer Cells

Keywords: Neoplasm; Signaling; Transcriptional Regulation; Cell Death; ChIP; chromatin immunoprecipitation; DN; dominant negative; EGFP; enhanced green fluorescent protein; EMSA; electrophoretic mobility shift assay; ESCC; esophageal squamous cell carcinoma; FITC;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E

Keywords: Mouse Model; Carcinogenesis; shRNA; CCK-8; AFP; α-fetoprotein; ChIP; chromatin immunoprecipitation; CHO; Chinese hamster ovary; EGFP; enhanced green fluorescent protein; GPC3; glypican 3; HA; hemagglutinin; HCC; hepatocellular carcinoma; mRNA; messenger

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

uPA and uPAR shRNA inhibit angiogenesis via enhanced secretion of SVEGFR1 independent of GM-CSF but dependent on TIMP-1 in endothelial and glioblastoma cells

Keywords: uPA and uPAR; shRNA; Angiogenesis; GlioblastomauPA, urokinase plasminogen activator; uPAR, urokinase plasminogen activator receptor; GM-CSF, granulocyte macrophage colony stimulating factor; SVEGFR1, soluble vascular endothelial growth factor receptor 1;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Reduced Efficacy of the Plk1 Inhibitor BI 2536 on the Progression of Hepatocellular Carcinoma due to Low Intratumoral Drug Levels

Keywords: AdV; adenovirus; CMV; cytomegalia virus; FACS; fluorescence-activated cell sorting; GEM; genetically engineered mouse; HCC; hepatocellular carcinoma; MRI; magnetic resonance imaging; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PARP;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

Keywords: Development; Mouse Model; Microbiota; Pediatric Gastrointestinal Disorder; ASBT; apical ileal sodium-dependent bile acid transporter; DAPI; 4′,6-diamidino-2-phenylindole; DBZ; dibenzapine; GFP; green fluorescent protein; IL; interleukin; LPS; lipopolysa

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Glucocorticoids Promote Hepatic Cholestasis in Mice by Inhibiting the Transcriptional Activity of the Farnesoid X Receptor

Keywords: Bile Acid Metabolism; Small Heterodimer Partners; Liver Disease; Nuclear Receptor; ALT; alanine aminotransferase; BA; bile acid; BMI; body mass index; ChIP; chromatin immunoprecipitation; CtBP; C-terminal binding protein; Cyp7A1; cytochrome P450, family 7

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner

Keywords: PDK1; 3-phosphoinositide-dependent protein kinase 1; PI3K; phosphatidylinositol 3 kinase; PIP3; phosphatidylinositol 3,4,5 triphosphate; PH; pleckstrin homology; shRNA; short hairpin RNA;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice

Keywords: Cox-2; Imp-1; ZBP1; Colorectal Cancer; Inflammatory Bowel Disease; α-SMA; α-smooth muscle actin; ARE; AU-rich elements; cDNA; complementary DNA; cMSC; colonic mesenchymal stem cell; GFP; green fluorescent protein; Igf2bp1; insulin-like growth factor 2 b

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2012 سفارش ترجمه

Flotillin-1 Promotes Tumor Necrosis Factor-α Receptor Signaling and Activation of NF-κB in Esophageal Squamous Cell Carcinoma Cells

Keywords: IκB Kinase Activation; Ubiquitination; Phosphorylation; Mouse Model; ESCC; esophageal squamous cell carcinoma; FLOT1; flotillin-1; HUVEC; human umbilical vein endothelial cells; IHC; immunohistochemistry; IκB; inhibitor of nuclear factor-κB; IκBα-mu;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2012 سفارش ترجمه

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

Keywords: AD; adamantane; ADEPT; antibody-directed enzyme prodrug therapy; ADR; doxorubicin/adriamycin; Av; avidin; AVET; adenovirus-enhanced transferrinfection; ART; artemisinin; BAP; biotin-adaptor peptide; BBB; blood-brain barrier; BFU-E; blast forming unit-er

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2012 سفارش ترجمه

Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis

Keywords: Glucose-regulated protein 78; GRP78; Colorectal carcinoma; ShRNA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of PCGF2 enhances granulocytic differentiation of acute promyelocytic leukemia cell line HL-60 via induction of HOXA7

Keywords: APL; acute promyelocytic leukemia; ATRA; all-trans retinoic acid; H3K27me3; tri-methylation at the 27th lysine residue (K27) of histone H3; PCGF2; polycomb group ring finger 2; PRC; Polycomb repressive complex; RARA; retinoic receptor alpha; RT-PCR; rever

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of genes associated to 2′,2′-difluorodeoxycytidine resistance in HeLa cells with a lentiviral short-hairpin RNA library

Keywords: araC; 1-β-arabinofuranocylcytosine; dCK; deoxycytidine kinase; dFdC; 2′,2′-difluorodeoxycytidine; 5-FdUrd; 5-fluorodeoxyuridine; RNAi; RNA interference; shRNA; short-hairpin RNA; siRNA; short-interfering RNA; SFPQ; splicing factor proline/glutamine-r

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles

Keywords: shRNA; AAV9; Neonatal

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion

Keywords: ASC; apoptosis-associated speck-like protein containing a CARD; CARD; caspase recruitment domain; EGCG; epigallocatechin-3-gallate; IL; interleukin; NLR; NOD-like receptor; NLRP; NACHT-, LRR- and pyrin-domain-containing protein; NOD; nucleotide oligomeriz

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Calpastatin is regulated by protein never in mitosis gene A interacting-1 (PIN1) in endothelial cells

Keywords: PIN1; protein never in mitosis gene A interacting-1; p; phosphorylated; S; serine; T; threonine; P; proline; shRNA; small hairpin RNA; siRNA; small inhibitory RNA; COX; cyclooxygenase; iNOS; inducible nitric oxide synthase; LPS; Escherichia coli endotoxin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Involvement of Cot activity in the proliferation of ALCL lymphoma cells

Keywords: Cot/tpl2; Erk1/2; Lymphoma; shRNA; Proliferation; p70 S6K;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport

Keywords: AEC1; alveolar epithelial cells type 1; AEC2; alveolar epithelial cells type 2; SIK1; salt-inducible kinase 1; siRNA; small inhibitory ribonucleic acid; shRNA; short hairpin ribonucleic acid; Iso; isoproterenol; Sodium transport; Na+, K+-ATPase activity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

PTOV1 antagonizes MED25 in RAR transcriptional activation

Keywords: NR; nuclear receptor; RAR; retinoic acid receptor; AtRA; all-trans retinoic acid; RXR; retinoid X receptor; CBP; CREB-binding protein; MED25; mediator protein 25; PTOV; prostate tumor over-expressed; DBD; DNA-binding domain; LBD; ligand-binding domain; GS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer

Keywords: 5-Aza-dC; 5-aza-2′-deoxycytidine; ChIP; chromatin immunoprecipitation; mRNA; messenger RNA; qRT-PCR; quantitative reverse transcription-polymerase chain reaction; shRNA; short hairpin RNA; Demethylation; Malignant phenotype; Gastric carcinogenesis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Constitutive and conditional RNAi transgenesis in mice

Keywords: RNAi; Conditional; shRNA; Cre recombinase; tetR/O; Transgenic mice; Rosa26; RMCE;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

CCR4 dependent migration of Foxp3+ Treg cells to skin grafts and draining lymph nodes is implicated in enhanced graft survival in CD200tg recipients

Keywords: CD200 transgene; Foxp3 + Treg; CCR4; CCL17/19; shRNA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Contributions of steroidogenic factor 1 to the transcription landscape of Y1 mouse adrenocortical tumor cells

Keywords: NIA; National Institute of Aging; SF-1; steroidogenic factor 1; shRNA; short hairpin RNA; cDNA microarray; Chromatin immunoprecipitation; Genome-wide transcription profiling; Short hairpin RNA (shRNA); Steroidogenic factor-1; Y1 mouse adrenocortical tumor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

Keywords: Voltage-gated K channel; Cell proliferation; Cell cycle progression; G1-S transition; Margatoxin; shRNA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells

Keywords: α-CTF; α-cleaved carboxyterminal fragment of APP (also known as C83); Aβ; amyloid-β peptide; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BACE; β-secretase; BBG; brilliant blue G; BzATP; 2′(3â€

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles

Keywords: RNAi; shRNA; Adriamycin; Survivin; Poly(2-dimethylaminoethylamine/2-(2-aminoethyoxy)ethoxy)phosphazene (PDMAE)

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of netrin-1 and netrin-1 knockdown on human umbilical vein endothelial cells and angiogenesis of rat placenta

Keywords: Netrin-1; shRNA; Transfection; HUVECs; Angiogenesis; Placenta;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه