Diacylglycerol-containing oleic acid induces increases in [Ca2+]i via TRPC3/6 channels in human T-cells

► DAG-containing OA induces increases in [Ca2+]i in human T-cells. ► Such increases are via opening of TRPC3 and TRPC6 channels. ► Oleic acid at the sn-2 position confers the molecular property to the diacylglycerol. ► Disruption of lipid rafts completely abolished POG-evoked increases in [Ca2+]i.