Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport

► All SIK isoforms are expressed in lung cells and tissue from human, mouse and rat. ► SIK1 mediates the increase in sodium transport in response to isoproterenol. ► SIK1 is activated by isoproterenol. ► SIK1 is needed to activate the Na+, K+-ATPase in response to isoproterenol. ► SIK1 is needed for the transport of Na+, K+-ATPase to the plasma membrane.