Involvement of Cot activity in the proliferation of ALCL lymphoma cells

► We show here that ALCL lymphoma cell lines present high levels of Cot (MAP3K8). ► We show that Cot mediates the constitutive Erk1/2 activation in SUDHL-1 cells. ► Inhibition of Cot activity reduces the number of cell divisions in SUDHL-1 cells. ► Cot controls the activation state of p70 S6K and JunB expression in SUDHL-1 cells.