Keywords: گیرنده سیگما-1; Sigma-1 receptor; Ischemia-reperfusion; Blood-brain barrier; Vascular dementia;
مقالات ISI گیرنده سیگما-1 (ترجمه نشده)
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Keywords: گیرنده سیگما-1; AC927; 1-(2-phenylethyl)piperidine; AMPH; amphetamine; ATS; amphetamine-type stimulants; AZ66; 3-(4-(4-cyclohexylpiperazin-1-yl)pentyl)-6-flourobenzo(Abadias et al., 2013)thiazol-2(3H)-one; BD1008; N-(Brammer et al., 2006)-N-methyl-1-pyrrolidineethanamine
Keywords: گیرنده سیگما-1; Growth factor; Neurotrophin; Axon sprouting; Synaptic plasticity; 6-Hydroxydopamine; MPTP; Sigma-1 receptor; Synuclein;
Keywords: گیرنده سیگما-1; HD; Huntington disease; Htt; Huntingtin; MSN; medium spiny neuron; S1R; sigma-1 receptor; ER; endoplasmic reticulum; YAC128; yeast artificial chromosome 128Q expansion mice; 3-PPP; R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride; SOC; store-oper
Keywords: گیرنده سیگما-1; Targeted drug delivery; Unimolecular micelles; Retina; Ganglion cell targeting; Excitotoxicity; Sigma-1 receptor; Cholera toxin B domain;
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Pentylenetetrazol; Bicuculline; NE-100; E1R; Anti-convulsive activity;
Keywords: گیرنده سیگما-1; Sigma-1 receptor; PRE-084; Post-traumatic stress disorder; Single prolonged stress;
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Endoplasmic reticulum; Calcium signaling; Chaperone activity; Neuropathology
Keywords: گیرنده سیگما-1; Anisamide; Sigma-1 receptor; Receptor-mediated endocytosis; Drug targeting;
Keywords: گیرنده سیگما-1; Sigma receptor; Sigma-1 receptor; ER stress; MAM; Chaperone
Keywords: گیرنده سیگما-1; Perinatal brain injury; Glutamate excitotoxicity; NMDA receptor; Sigma-1 receptor; Inflammation; Endoplasmic reticulum; Mitochondria;
Keywords: گیرنده سیگما-1; Lipid raft; Neuroprotection; Neurorestoration; Sigma-1 receptor; Stroke
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Huntington's disease; Neuronal nuclear inclusions; Ubiquitin-proteasome system; Endoplasmic reticulum chaperone; Endoplasmic reticulum-associated degradation;
Keywords: گیرنده سیگما-1; Antitumor agents; Chemotherapy; Drug targeting; Positron emission tomography; Sigma-1 receptor; Sigma-2 receptor
Keywords: گیرنده سیگما-1; BDNF; brain-derived neurotrophic factor; CFA; caudal forelimb area; ChR2; channelrhodopsin-2; CIMT; constraint-induced movement therapy; CSPGs; chondroitin sulfate proteoglycans; iTBS; intermittent theta burst stimulation; MSCs; mesenchymal stem cells; PN
Keywords: گیرنده سیگما-1; Sig-1R; sigma-1 receptor; TNC; trigeminal nucleus caudalis; Fos-IR; Fos immunoreactive neurons; CNS; central nervous system; Extracellular signal-regulated kinase; Fos; Migraine; NMDA receptor; Sigma-1 receptor; Trigeminal nucleus caudalis;
Keywords: گیرنده سیگما-1; Primary retinal ganglion cells; Sigma-1 receptor; Neuroprotection; Extracellular signal-regulated kinases 1/2;
Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain
Keywords: گیرنده سیگما-1; Sigma-1 receptor; HMGB1; Diabetes; Peripheral neuropathy; Spinal cord;
AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease
Keywords: گیرنده سیگما-1; Alzheimer's disease; Amyloid; Cholinergic; Cognition; Disease modifier; M1 muscarinic receptor; Neuroinflammation; Sigma-1 receptor;
Spinal Sigma-1 Receptor-mediated Dephosphorylation of Astrocytic Aromatase Plays a Key Role in Formalin-induced Inflammatory Nociception
Keywords: گیرنده سیگما-1; MAM; mitochondria-associated endoplasmic reticulum membrane; LET; Letrozole; DMSO; dimethyl sulfoxide; HPC; hydroxypropyl cellulose; aromatase; sigma-1 receptor; dephosphorylation; acute pain; inflammatory pain;
Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the Ï1 receptor
Keywords: گیرنده سیگما-1; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; Aβ25-35; amyloid-β[25-35] peptide; BDNF; brain-derived neurotrophic factor; BiP; 78 kDa glucose-regulated protein; cAMP; cyclic adenosine monophosphate; CREB;
Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer
Keywords: گیرنده سیگما-1; AWZXAAFPWAXAOV-UHFFFAOYSA-N; VCKYUMDZRLPKLV-UHFFFAOYSA-N; PUUYAOSAGFBJKV-UHFFFAOYSA-N; DOFFSRGAEKCJAF-UHFFFAOYSA-N; JABKQQAOOJHXSC-LCWMZCLWSA-N; Sigma1; Sigma-1 receptor; Sigma-1 chaperone; Prostate cancer; Guanidine; Small molecule inhibitor;
MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor
Keywords: گیرنده سیگما-1; miR-297; Sigma-1 receptor; Cardiac hypertrophy; Endoplasmic reticulum stress;
(+)-and (â)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/Ï1 antagonist properties and antinociceptive effects
Keywords: گیرنده سیگما-1; Sigma-1 receptor; (+)-Phenazocine; (â)-Phenazocine; Mechanical antinociception; Bifunctional ligand; Opioid;
Sigma 1 receptor activation modifies intracellular calcium exchange in the G93AhSOD1 ALS model
Keywords: گیرنده سیگما-1; ALS; amyotrophic lateral sclerosis; AMPA; Î-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CTCF; corrected total cell fluorescence; ERMCC; ER mitochondria Ca2+ cycle; G93A; G93AHSOD1; MAM; mitochondria-associated ER membrane; NE-100; 4-methoxy-3-(2-
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain
Keywords: گیرنده سیگما-1; D-serine; sigma-1 receptor; GluN1 phosphorylation; protein kinase C; neuropathic pain;
Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism
Keywords: گیرنده سیگما-1; Neurosteroid; Dehydroepiandrosterone sulphate; Pregnenolone sulfate; P2X; Sigma-1 receptor; Mechanical allodynia
Synthesis and biological evaluation of novel 6,7-dihydro-5H-cyclopenta[d]pyrimidine and 5,6,7,8-tetrahydroquinazoline derivatives as sigma-1 (Ï1) receptor antagonists for the treatment of pain
Keywords: گیرنده سیگما-1; Ï1R; sigma-1 receptor; Ï2R; sigma-2 receptor; NMDA; N-methyl-d-aspartate; CNS; central nervous system; PNS; peripheral nervous system; KO; knockout; WT; wild-type; [3H]-DTG; [3H]-di-o-tolylguanidine; SAR; structure-active relationship; FRET; fluorescenc
Solution NMR studies reveal the location of the second transmembrane domain of the human sigma-1 receptor
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Transmembrane domain; NMR;
Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS)
Keywords: گیرنده سیگما-1; Sigma-1 receptor; ALS; C-terminals; Motoneurons
Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage
Keywords: گیرنده سیگما-1; Caspase 3/7 activity; Endoplasmic reticulum stress; Photoreceptor degeneration; Retinal dysfunction; Sigma-1 receptor;
SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models
Keywords: گیرنده سیگما-1; Akt; Extracellular signal-regulated kinase (ERK) 1/2; Sigma-1 receptor;
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation
Keywords: گیرنده سیگما-1; ALS; Amyotrophic lateral sclerosis; APP; Amyloid precursor protein; BDNF; brain derived neurotrophic factor; CNS; Central nervous system; ER; endoplasmic reticulum; FTLD-MND; Fronto-temporal lobar degeneration with co-occurrence of motor neuron disease; F
Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic
Keywords: گیرنده سیگما-1; 3,4-Dihydro-2(1H)-quinolinone; Sigma-1 receptor; Antagonist; Analgesic
Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats
Keywords: گیرنده سیگما-1; p38 MAPK; Sigma-1 receptor; Mechanical allodynia; Neuropathic pain;
Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells
Keywords: گیرنده سیگما-1; purified retinal ganglion cells; L-type Voltage Gated Calcium Channel; calcium signaling; sigma-1 receptor; KCl; Potassium Chloride; Ï-1r; sigma-1 receptor; VGCCs; Voltage Gated Calcium Channels; L-type VGCCs; L-type Voltage Gated Calcium Channels; RGCs;
3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor
Keywords: گیرنده سیگما-1; Pentacycloundecylamines; Sigma-1 receptor; CoMFA; Glaucomatous neurodegeneration; Homology modeling
Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects
Keywords: گیرنده سیگما-1; Sigma-1 receptor; S1RA (E-52862); Opioid adjuvant; Antinociception; Tolerance; Reward
Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes
Keywords: گیرنده سیگما-1; Fura-2/AM; Intracellular calcium concentration; Knockout mice; Voltage-dependent calcium channel; Sigma-1 receptor; Synaptosome
Imipramine protects mouse hippocampus against tunicamycin-induced cell death
Keywords: گیرنده سیگما-1; Endoplasmic reticulum stress; Hippocampus; Imipramine; Sigma-1 receptor; Tunicamycin
Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice
Keywords: گیرنده سیگما-1; Bw; bodyweight; ip; intraperitoneal; NMDAR; N-methyl-d-aspartate receptor; PRE-084; 2-(4-morpholinethyl) 1-phenylcyclohexanecarboxylate; Ï1R; sigma-1 receptor; Neonatal brain injury; Excitotoxicity; Sigma-1 receptor agonist; PRE-084;
Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N′-dimethyltryptamine forming enzyme, indole-N-methyl transferase
Keywords: گیرنده سیگما-1; sigma-1 receptor; INMT; DMT; motoneurons; C-terminals; endoplasmic reticulumDMT, dimethyltryptamine; DTG, 1,3-di(2-tolyl)guanidine; INMT, indole-N-methyl transferase; M2AChR, muscarinic type 2 acetylcholine receptor; MN, motoneuron; PBS, phosphate-buffere
The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Metabolomic; ER stress; Antioxidant response element; Oxidative stress; Quinone oxidoreductase 1; Superoxide dismutase 1;
Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Transcription factor; ATF4; Mental disorders; ER stress; Protective function
Sigma-1 receptor stimulation with fluvoxamine activates Akt–eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Thoracic aorta; Myocardial hypertrophy; Protein kinase B (Akt); Endothelial nitric oxide synthase (eNOS)
Inhibition of sigma-1 receptor reduces N-methyl-d-aspartate induced neuronal injury in methamphetamine-exposed and -naive hippocampi
Keywords: گیرنده سیگما-1; NMDA; Methamphetamine; Hippocampus; Sigma-1 receptor
Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCα and É, but not the PKCζ, isoforms
Keywords: گیرنده سیگما-1; Sigma-1 receptor; Protein kinase C; NMDA receptor; Phosphorylation; Pain facilitation;
Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells
Keywords: گیرنده سیگما-1; Akt; BDNF; Fluvoxamine; Sigma-1 receptor; Phosphorylation
An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: Involvement of the sigma-1 receptor
Keywords: گیرنده سیگما-1; DHEAS; NMDA; Pain; Sigma-1 receptor; Phosphorylation of NR1
The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study
Keywords: گیرنده سیگما-1; sigma-1 receptor; subsurface cisternae; C-terminals; motoneuron; Kv2.1; m2AChR; ER; endoplasmic reticulum; KO; knockout; PBS; phosphate buffered saline; WT; wildtype;