Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice

► We evaluate neuroprotective effects of a highly selective sigma receptor agonist. ► We use an established mouse model of neonatal excitotoxic brain injury. ► Administration of PRE-084 reduces cell death and microglial cell activation. ► PRE-084 has a beneficial effect in vitro after glutamate exposure. ► Sigma receptor agonists are a potential strategy in perinatal brain injury.