Digital PCR strategies in the development and analysis of molecular biomarkers for personalized medicine
Keywords: مولکول تک; Digital PCR; Single molecule; Biomarkers;
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Abundance, distribution, mobility and oligomeric state of M2 muscarinic acetylcholine receptors in live cardiac muscle
Keywords: مولکول تک; Single molecule; TIRF; Acetylcholine receptor; Muscarinic; Cardiomyocyte;
In silico FRET from simulated dye dynamics
Keywords: مولکول تک; Fluorescence resonance energy transfer; Molecular conformation; Monte Carlo; Molecular dynamics; Markov Chain; Single molecule;
Probing concentration-dependent behavior of DNA-binding proteins on a single-molecule level illustrated by Rad51
Keywords: مولکول تک; Single molecule; DNA; Rad51; Microfluidics; Supported lipid bilayer; Fluorescence microscopy;
Probing plasma membrane dynamics at the single-molecule level
Keywords: مولکول تک; membrane dynamics; single molecule; membrane microdomains
Addressing potent single molecule AFM study in prediction of swelling and dissolution rate in polymer matrix tablets
Keywords: مولکول تک; CRT, controlled-release technology; Xan, xanthan; AFM, atomic force microscopyAFM; Xanthan; Single molecule; Nanoindentation; Matrix tablets; Swelling
Effects of histone acetylation and CpG methylation on the structure of nucleosomes
Keywords: مولکول تک; Nucleosome; Histone acetylation; DNA methylation; Single molecule; FRET; Fluorescence anisotropy
Quantum dots to tail single bio-molecules inside living cells
Keywords: مولکول تک; Single molecule; Quantum dots; Nanoparticle tracking; Live cell; Intracellular transport
Single molecule enzyme-linked immunosorbent assays: Theoretical considerations
Keywords: مولکول تک; Digital ELISA; Single molecule; Kinetics; PSA;
Elimination of fluorescence intensity difference in orientation determination of single molecules by highly focused generalized cylindrical vector beams
Keywords: مولکول تک; Orientation determination; Single molecule; Cylindrical vector beam; Polarization; Confocal microscopy
On photo-oxidation of single molecules
Keywords: مولکول تک; Fluorescence; Single molecule; Photo-oxidation; Photo-bleaching; Terrylene; Oxygen phosphorescence
Intermediate intensity levels during the emission intermittency of single CdSe/ZnS quantum dots
Keywords: مولکول تک; Semiconductor; Quantum dot; Colloidal; Blinking; Single molecule; Optical microscopy;
Discrimination of neutral oligosaccharides through a nanopore
Keywords: مولکول تک; Nanopore; α-Hemolysin; Oligosaccharides; Single molecule; Translocation;
Counting proteins bound to a single DNA molecule
Keywords: مولکول تک; DNA; Fluorescence; Protein counting; Single molecule
Effect of chemical cross-linking on the mechanical properties of elastomeric peptides studied by single molecule force spectroscopy
Keywords: مولکول تک; Elastomeric; Elastin; Aggregation; Single molecule; AFM;
High accuracy FIONA–AFM hybrid imaging
Keywords: مولکول تک; Atomic force microscopy (AFM); Fluorescence imaging with one nanometer accuracy (FIONA); Single molecule; Multi-protein complexes; Image registration
Construction of a fully active Cys-less elongation factor Tu: Functional role of conserved cysteine 81
Keywords: مولکول تک; aa-tRNA; aminoacyl-tRNA; EF-Tu; elongation factor Tu; FRET; fluorescence resonance energy transfer; sm; single molecule; LB; Luria-Bertani; TPCK; N-tosyl-l-phenylalanylchloromethane; Pi; inorganic phosphate; IPTG; isopropyl-β-d-thiogalactopyranoside; S
Protein folding at single-molecule resolution
Keywords: مولکول تک; Protein folding landscapes; Protein dynamics; Intrinsically disordered protein; Osmolyte; Chaperone; Single molecule
Kinetic Partitioning Mechanism Governs the Folding of the Third FnIII Domain of Tenascin-C: Evidence at the Single-Molecule Level
Keywords: مولکول تک; AFM, atomic force microscopy; FnIII, fibronectin type III; SMD, steered molecular dynamics; WLC, worm-like chain; wt, wild typekinetic partitioning; protein folding; single molecule; force spectroscopy; tenascin
Cytoplasmic dynein is not a conventional processive motor
Keywords: مولکول تک; Optical trap; Single molecule; Motor mechanics;
Hopping around an entropic barrier created by force
Keywords: مولکول تک; Single molecule; Proteins; Force spectroscopy; Hopping; Protein folding; Langevin dynamics;
Dynamical theory for photon and photoelectric pulse distributions in single molecule fluorescence
Keywords: مولکول تک; Single molecule; Photon distribution function; Fluctuations;
Nucleotide-dependent behavior of single molecules of cytoplasmic dynein on microtubules in vitro
Keywords: مولکول تک; AMP-PNP; 5â²-adenylylimidodiphosphate; Vi; vanadate; Cytoplasmic dynein; Dynactin; p150; Single molecule; Microtubule;
Photoluminescent nanodiamonds: Comparison of the photoluminescence saturation properties of the NV color center and a cyanine dye at the single emitter level, and study of the color center concentration under different preparation conditions
Keywords: مولکول تک; Diamond; Color center; Nanoparticle; Photoluminescence; Single molecule
Coordinate and time-dependent diffusion dynamics in protein folding
Keywords: مولکول تک; Position dependent diffusion; Time-dependent diffusion; Transition state; Mean first-passage time; Cold shock protein; Single molecule; Molecular dynamic simulation;
Preparation of cell membranes for high resolution imaging by AFM
Keywords: مولکول تک; Cell membranes; Single molecule; In-situ AFM
Stimulation of F1-ATPase activity by sodium dodecyl sulfate
Keywords: مولکول تک; Single molecule; Optical microscopy; Detergent; Torque; ATP synthase; ATP hydrolysis
Single-molecule FRET of protein-nucleic acid and protein-protein complexes: Surface passivation and immobilization
Keywords: مولکول تک; Single molecule; Nucleic acid-protein complex; FRET; TIRF; Vesicle;
Single-photon emission from a single nanoparticle consisting of a single conjugated polymer chain
Keywords: مولکول تک; Conjugated polymer; MEH-PPV; Nanoparticle; Single molecule; Single photon; Antibunching
Forces-induced pinpoint denaturation of short DNA
Keywords: مولکول تک; Laser; spFRET; DNA denaturation; Single molecule; Short DNA
Single molecule approaches to transcription factor kinetics in living cells
Keywords: مولکول تک; Single molecule; Transcription factor; Facilitated diffusion
Photon distribution function in blinking fluorescence of individual molecules
Keywords: مولکول تک; 36.20.Ey; 81.07.Nb; 42.50.Lc; Single molecule; Photon distribution function; Fluctuations;
Single molecule transcription elongation
Keywords: مولکول تک; Single molecule; Optical trapping; RNA polymerase II; Transcriptional pausing; Backtracking; TFIIS; Molecular motor; Diffusion
Total internal reflection with fluorescence correlation spectroscopy: Applications to substrate-supported planar membranes
Keywords: مولکول تک; Fluorescence microscopy; Optical microscopy; Evanescent; Fluctuation; Single molecule; Surface binding; Diffusion; Supported membranes; Cell membranes
Mechanical Unfolding of Two DIS RNA Kissing Complexes from HIV-1
Keywords: مولکول تک; HIV-1, human immunodeficiency virus 1; DIS, dimerization initiation site; MMLV, Maloney murine leukemia virus; dsDNA, double-stranded DNAkissing RNA; metal ion binding; single molecule; mechanical unfolding; optical tweezers
Single molecule fluorescence autocorrelation measurement on anisotropic molecular diffusion in nematic liquid crystal
Keywords: مولکول تک; Single molecule; Liquid crystal; Autocorrelation function; Fluorescence correlation; Diffusion coefficient
Determination of torque generation from the power stroke of Escherichia coli F1-ATPase
Keywords: مولکول تک; F1-ATPase; Gold nanorod; Molecular motor; High-speed data acquisition; Single molecule;
Covalent attachment of proteins to calcite surface for the single molecule experiments
Keywords: مولکول تک; Calcite; Single molecule; Albumin; Attachment; AFM
Structural effects of nogalamycin, an antibiotic antitumour agent, on DNA
Keywords: مولکول تک; DNA; Nogalamycin; Antibiotic; Antitumour; Anthracyclin; Intercalation; DNA–drug interaction; Atomic force microscopy (AFM); Single molecule; Plectonemic coiling
Effect of external torque on the ATP-driven rotation of F1-ATPase
Keywords: مولکول تک; Molecular motor; Single molecule; F1-ATPase; External force; Tight coupling
Zero-mode waveguides: Sub-wavelength nanostructures for single molecule studies at high concentrations
Keywords: مولکول تک; Zero-mode waveguides; Fluorescence correlation spectroscopy; Single molecule; Nanostructures; Sub-wavelength apertures
Fluorescence correlation spectroscopy for the study of membrane dynamics and protein/lipid interactions
Keywords: مولکول تک; Fluorescence correlation spectroscopy; Single molecule; Model membrane; Giant unilamellar vesicle; Supported lipid bilayer; Lipid dynamics; Protein/lipid interactions; Membrane organization; Molecular interactions;
Cofilin Increases the Bending Flexibility of Actin Filaments: Implications for Severing and Cell Mechanics
Keywords: مولکول تک; single molecule; imaging; biopolymer mechanics; persistence length; severing
Biased Brownian motion mechanism for processivity and directionality of single-headed myosin-VI
Keywords: مولکول تک; Molecular motor; Vesicle transport; Single molecule; Unconventional myosin; Biased Brownian motion;
Measurement system for simultaneous observation of myosin V chemical and mechanical events
Keywords: مولکول تک; Single molecule; Chemo-mechanical coupling; Processive motor; Myosin V; Simultaneous observation
A Large Collapsed-state RNA Can Exhibit Simple Exponential Single-molecule Dynamics
Keywords: مولکول تک; CthermoL18, catalytic domain of RNase P RNA from Bacillus stearothermophilus labeled with a FRET pair on the 3′ end and L18 loop; FRET, fluorescence resonance energy transfer; EFRET, efficiency of resonance energy transferFRET; single molecule; RNA foldin
Modulation of T4 gene 32 protein DNA binding activity by the recombination mediator protein UvsY
Keywords: مولکول تک; gp32, T4 Gene 32 protein; UvsY, T4 recombination mediator protein; ssDNA, single-stranded DNA; dsDNA, double-stranded DNA; SSB, single-stranded binding protein; RMP, recombination mediator proteinDNA melting; single molecule; DNA stretching; SSB; recombin
New in situ hybridization towards single-RNA detection
Keywords: مولکول تک; In situ hybridization; Wide-field fluorescence microscopy; Memory genes; Single molecule; Quantitative imaging; Drosophila;
Manipulation of magnetic particles by patterned arrays of magnetic spin-valve traps
Keywords: مولکول تک; Magnetic traps; Magnetic tweezers; Single molecule; Microfluidics; Spin-valve arrays
Single-molecule selection and recovery of structure-specific antibodies using atomic force microscopy
Keywords: مولکول تک; Phage display; Single-chain antibody fragment; Atomic force microscopy; Single molecule; Protein misfolding