کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10764065 1050530 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hopping around an entropic barrier created by force
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Hopping around an entropic barrier created by force
چکیده انگلیسی
► Application of mechanical force on a single molecule introduces an entropic barrier separating the collapsed from a force-driven extended conformation of the molecule. ► The force-induced entropic barrier exhibits long distance to the transition state, up to tens of nanometers. ► The entropic barrier vanishes at zero force, and influences dramatically the kinetics of the molecule's transition between states. ► Langevin dynamics across such force induced barriers readily demonstrates the hopping behavior observed for a variety of single molecules placed under force. ► Such hopping is frequently misinterpreted as a manifestation of two-state folding/unfolding reactions observed in bulk experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 403, Issue 1, 3 December 2010, Pages 133-137
نویسندگان
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