Keywords: BMAL1; brain and muscle ARNT-like 1; CCG; clock-controlled genes; CLOCK; circadian locomoter output cycles protein kaput; CRY; Cryptochrome; KO; knock-out; NAD+; nicotinamide adenine dinucleotide (oxidized); NADH; nicotinamide adenine dinucleotide (reduce
مقالات ISI (ترجمه نشده)
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Keywords: AD; Alzheimer's disease; PPs; polyphenols; EGCG; epigallocatechin gallate; NFTs; neurofibrillary tangles; ACh; acetylcholine; Aβ; amyloid-beta; APP; amyloid precursor protein; PS-1; presenilin-1; PS-2; presenilin-2; AChE; acetylcholine esterase; Cdk5;
Keywords: FK228 (PubChem CID: 5352062); PXD101 (PubChem CID: 6918638); SAHA (PubChem CID: 5311); LBH-589 (PubChem CID: 6918837); tubacin (PubChem CID: 6675804); tubastatin A (PubChem CID: 49850262); ACY-1215 (PubChem CID: 53340666); ACY-241 (PubChem CID: 53340426);
Keywords: Aging brain; Cognitive deficits; Cannabinoids; Sirtuin; Magnetic resonance imaging (MRI);
Keywords: Parkinson's disease; Ghrelin; Dementia; AHN; adult hippocampal neurogenesis; AD; Alzheimer's Disease; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; AMP-activated protein kinase; AB; amyloid-β; ATG; autophagy-related; BBB; blood brain
Keywords: SIRT2; Sirtuin; Non-small cell lung cancer; Crystallographic analyses; Substrate mimicking;
Keywords: Sirtuin; SIRT; Renal cell carcinoma; RCC; Immunohistochemistry;
Keywords: Histone acetylation; Creb-binding protein; Cbp; Sirtuin; HDAC inhibitor; Beta-hydroxybutyrylation; Dietary restriction; Ketogenic diet; Aging; Caloric restriction;
Keywords: Diabetes mellitus; Antioxidants; Oxygen free radicals; Nitrative stress; Animal; Human; eNOS; endothelial nitric oxide synthase; NOS3; nitric oxide synthase 3; cNOS; constitutive nitric oxide synthase; nNOS; neuronal nitric oxide synthase; iNOS; induced n
Keywords: DAC; 5-Aza-2â²-deoxycytydine; DNMT; DNA methyltransferase; HAT; histone acetyltransferase; HDAC; histone deacetylase; HDACì; HDAC inhibitors; IL-2; interleukin-2; INS; insulin; LADA; latent autoimmune diabetes in adults; miRNA; microRNA; PBMCs; peripher
Keywords: aging; oxidative stress; physical activity; sirtuin; skeletal muscle
Keywords: ORF; open reading frame; CWPs; cyst wall proteins; HDAC; histone deacetylase; HAT; histone acetyl transferase; IFA; immunofluorescence assay; VSP; variant-specific surface protein; mAb; monoclonal antibody; qPCR; quantitative polymerase chain reaction; Ch
Keywords: AMPK; AMP-activated protein kinase; BM; bone marrow; CAT; catalase; Complex I; NADH-coenzyme Q oxidoreductase; Complex II; succinate-coenzyme Q oxidoreductase; Complex III; ubiquinol-cytochrome c oxidoreductase; COX; cytochrome c oxidase; Complex V; FoF1A
Keywords: Îp; proton motive force established on inner mitochondrial membrane; ÎÏ; electrical membrane potential established on inner mitochondrial membrane; COX4.1; cytochrome c oxidase subunit 4 isoform 1; ERK; extracellular signal-regulated kinase; FA; fatty
Keywords: Sirtuin; Inhibitor; Virtual screening;
Keywords: Resveratrol; Sirtuin; Obesity; Type 2 diabetes; Mitochondria
Keywords: NAD+; nicotinamide adenine dinucleotide; SIRT; sirtuin; PARP; poly(ADP-ribose) polymerase; OHCs; outer hair cells; ROS; reactive oxygen species; NOX; NAD(P)H oxidases; TNF; tumor necrosis factor; RANTES; regulated on activation normal T-cell expressed and
Keywords: CAC; citric acid cycle; ROS; reactive oxygen species; SIRT; sirtuin; STACs; sirtuin-activating compounds; Aerobic glycolysis; Cancer; Epigenetics; Sirtuins; The Warburg effect;
Keywords: 8-IP; 8-isoprostane; A1A; α1-antitrypsin; A1AD; α1-antitrypsin deficiency; AEP; acute eosinophilic pneumonia; AMP; antimicrobial peptide; CRS; chronic rhinosinusitis; CS; cigarette smoke; DI; deletion/insertion; DIP; desquamative interstitial pneumonia;
Keywords: Aging; Metabolism; Diet restriction; Sirtuin; mTOR; Insulin;
Keywords: Ah receptor; aryl-hydrocarbon receptor; amu; atomic mass unit; ASA; Acetyl salicylic acid; ATP; adenosine triphosphate; COX; cyclooxygenase; DHBA; dihydroxy benzoic acid; eNOS; endothelial nitric oxide synthase; GDH; glutamate dehydrogenase; HDAC; histone
Keywords: 4-HPR; N-(4-hydroxyphenyl)retinamide; 5â²-UTR; 5â²-untranslated region; 9-cis-RA; 9-cis retinoic acid; 9cUAB30; (2E,4E,6Z,8E)-8-(3â²,4â²-dihydro-1â²(2'H)-naphthalen-1â²-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; Acitretin; (2E,4E,6E,8E)-9-(4-met
Keywords: Sirtuin; Class III HDAC inhibitor; Marine-derived Streptomyces sp.; 4-Dimethylaminobenzoic acid; 4-tert-Butylbenzoic acid;
Keywords: Metabolism; Epigenetics; Lactate dehydrogenase; Sirtuin; Oxidative stress;
Keywords: ACLY; ATP-citrate lyase; ATM; ataxia telangiectasia mutated; BCL-2; B-cell leukemia-2; Chk2; checkpoint homolog kinase 2; CiC; citrate carrier; DIC; dicarboxylate carrier; DNMT; DNA methyltransferase; FH; fumarate hydratase; H3K27; histone 3 lysine 27; HA
Keywords: Sirtuin; Benzimidazole; Electron donating; Anti-proliferative; Breast cancer
Keywords: AceCS2; acetyl-CoA synthetase 2; ADP; adenosine diphosphate; CPS1; carbamoyl phosphate synthetase 1; CPT1; carnitine palmitoyltransferase I; CR; calorie restriction; FOXO3a; forkhead box 03a; GDH; glutamate dehydrogenase; HeLa; human cervical carcinoma ce
Keywords: AGEs; advanced glycation end products; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate aminotransferase; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; GCL; glutamate cysteine ligase; GSH; glutathione; HO-1; heme oxyge
Keywords: Multiple sclerosis; Brain volume; Multivariate regression; Histone deacetylase; Mitochondria; Sirtuin;
Keywords: Caloric restriction; Aging; Mitochondria; Sirtuin; PGC-1a; Sarcopenia;
Keywords: Polyphenol; Phenolics; Sirtuin; Alzheimer's disease;
Keywords: AD; Alzheimer's disease; CR; caloric restriction; DRG; dorsal root ganglion; Drp1; dynamin-related protein 1; HAT; histone acetyltransferase; HD; Huntington's disease; HDAC; histone deacetylase; Hsp90; heat shock protein 90; KAT; lysine acetyltransferases
Keywords: Osteoclast; Oxidative stress; Heme-oxygenase 1 (HO-1); Nrf2; FOXO; Sirtuin
Keywords: Hearing loss; Aging; Inner ear; Oxidative stress; Sirtuin
Keywords: Sirtuin; MM-GBSA; MM-PBSA; Virtual screening
SIRT4 is the last puzzle of mitochondrial sirtuins
Keywords: Sirtuin; Mitonchondrial sirtuin; SIRT4; Enzymatic activity; Biological function;
Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice
Keywords: Energy metabolism; Sirtuin; Post-translational modification; Mitochondria;
Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1
Keywords: Beige adipocyte; Aging; Mesenchymal stem cells; Sirtuin; Senescence;
Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway
Keywords: HSCs; hepatic stellate cell; TGFβ1; Transforming growth factor β1; PTEN; Phosphatase and tensin homolog deletion 10; DNMT; DNA methyltransferase; ECM; extracellular matrix; α-SMA; α-smooth muscle actin; CCl4; carbon tetrachloride; PTP1B; protein tyros
Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6
Keywords: Sirtuin; NAD+-dependent deacetylation; Inhibition; NAD+; nicotinamide adenine dinucleotide; NAM; nicotinamide; AADPR; O-acetyl-ADP-ribose; TSA; trichostatin A; HDAC; histone deacetylase; TFA; trifluoroacetic acid; MMS; methyl methanesulfonate;
A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
Keywords: Ac-INH; acetyl-Isoniazid; Ac-PABA; acetyl-p-aminobenzoic acid; APC; allophycocyanin; CHO; Chinese hamster ovary cells; DMEM; Dulbecco's modified Eagle's medium; E2F1; E2F transctriptios factor 1; ER81; ETS-related protein 81; FITC; fluorescein IsoTioCyana
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development
Keywords: Osteoarthritis; Chondrocyte; Sirtuin; Deacylase; SIRT7; SOX9;
Cellular substrate limitations of lysine acetylation turnover by sirtuins investigated with engineered futile cycle enzymes
Keywords: Lysine Acetylation; Sirtuin; O-acetyl-ADP-ribose; Metabolism; Heterochromatin; Epigenetics;
Sirtuins in mitochondrial stress: Indispensable helpers behind the scenes
Keywords: Mitochondrial stress; Sirtuin; UPRmt; Antioxidant; Mitophagy;
Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells
Keywords: AmA; antimycin A; AMPK; adenosine monophosphate-activated protein kinase; CoQ; coenzyme Q10; DCF; 2â²,7â²-dichlorofluorescin; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate; ddPCR; droplet digital PCR; ETS; electron transfer system; FBS; fetal bovine s
Sirtuin activators and inhibitors: Promises, achievements, and challenges
Keywords: CR; calorie restriction; DHP; 1,4-dihydropyridine; ECS; extended C-site; ELT; Encoded Library Technology; FdL; Fluor de Lys; HD; Huntington's disease; LPS; lipopolysaccharide; LDL; low density lipoprotein; MLS; mitochondrial localization sequences; NAM; n
Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic
Keywords: Obesity; Chronic low-grade inflammation; Pharmacotherapy; Novel targets; Medicinal plants; Clinical studies; Contents; 5HT2CR; Serotonin receptors subtype 2C; ACC; Acetyl-CoA carboxylase (EC 6.4.1.2); ACTH; Adrenocorticotropic hormone; AgRP; Agouti-relate
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
Keywords: Atherosclerosis; CVD; Sirtuin; SIRT1; SIRT3; SIRT6; Oxidative stress; Lipid metabolism; ABC; Adenosine triphosphate binding cassette; ABCG; ABC sub-family G member; ADP; Adenosine diphosphate; AMPK; Adenosine monophosphate-activated protein kinase; eNOS;
Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications
Keywords: Sirtuin; SIRT1; Aging; Stem cells; Metabolism; Epigenetics;
Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease
Keywords: Sirtuin; Activator; Peptide; Aβ25-35; IMR-32; Allosteric; MCI; (Mild Cognitive Impairment); AD; (Alzheimer's disease); SIRT1; Sirtuin1; SPR; surface Plasmon resonance; RU; resonance unit; PVDF; Polyvinylidene fluoride; NTD; N domain; AFU; (arbitrary fl