Keywords: شرکای کوچک همجنسگرا; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
مقالات ISI شرکای کوچک همجنسگرا (ترجمه نشده)
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Keywords: شرکای کوچک همجنسگرا; aPKC; atypical protein kinase C; CBP; CREB binding protein; ChREBP; carbohydrate response element-binding protein; CREB; cAMP response element-binding protein; CRTC2; CREB-regulated transcription coactivator 2; FA; fatty acid; GIPR; glucose-dependent insu
Keywords: شرکای کوچک همجنسگرا; AHR; aryl hydrocarbon receptor; ALD; alcoholic liver disease; BAs; bile acids; CAR; constitutive androstane receptor; CARM1; coactivator associated arginine methyltransferases 1; CBP/P300; CREB-binding protein/p300; CYP27A1/Cyp27a1; sterol 27α-hydroxylas
Keywords: شرکای کوچک همجنسگرا; Sex differences; Steroids; Gut microbiota; Metabolic disease; Cardiovascular disease; ApoE; apolipoprotein E; BAs; bile acids; CVD; cardiovascular diseases; E1; estrone; E2; estradiol; E3; estriol; ER; estrogen receptor; FCG; four core genotypes; FMO3; fl
Keywords: شرکای کوچک همجنسگرا; BA; bile acids; BSH; bile salt hydrolase; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; LCA; litocholic acid; MCA; muricholic acid; CYP7A1; cholesterol 7-αhydroxylase; L.; Lactobacillus; B.; Bifidobacterium; EPS; exopolysaccharide;
Keywords: شرکای کوچک همجنسگرا; Parenteral nutrition; Liver disease; Steatosis; FXR; Bile salt signaling; PNALD; parenteral nutrition-associated liver disease; FXR; farnesoid X receptor; SHP; small heterodimer partner; FGF; fibroblast growth factor; ALT; alanine aminotransferase; AST; a
Keywords: شرکای کوچک همجنسگرا; GBT; gut bacterial translocation; TJ; tight junction; ZO-1; zonula occludens-1; FXR; farnesoid X receptor; MLN; mesenteric lymph nodes; OCA; obeticholic acid; SHP; small heterodimer partner; OTU; operational taxonomic units; TNF; tumor necrosis factor; IL
Keywords: شرکای کوچک همجنسگرا; ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: شرکای کوچک همجنسگرا; apo; apolipoprotein; HDL; high-density lipoprotein; HNF-1α,4α; hepatocyte nuclear factor-1α,4α; LRH-1; liver receptor homolog-1; Foxa2; forkhead box A2; PAF; platelet activating factor; LXR; liver X receptor; RXR; retinoid X receptor; FXR; farnesoid X
Keywords: شرکای کوچک همجنسگرا; AR; androgen receptor; CAR; constitutive androstane receptor; DBD; DNA-binding domain; EDC; endocrine disrupting chemical; ER; estrogen receptor; FXR; farnesoid X receptor; GR; glucocorticoid receptor; HRE; hormone responsive elements; LBD; ligand-binding
Keywords: شرکای کوچک همجنسگرا; AA; arachidonic acid; aP2 (or FABP4); adipocyte protein 2; BMD; bone mass density; BMP-2; bone morphogenic protein-2; CE; cholesterol esters; CHL; cholesterol; cAMP; cyclic 3,5-adenosine monophosphate; CLA; conjugated isomers of linoleic acid; COX; cycloo
Keywords: شرکای کوچک همجنسگرا; Cholesterol; Oxysterol; CYP46A1; CYP27A1; CYP3A4; CYP39A1; CYP7B1; CH25H; Cholesterol 7α-hydroxylase; Sterol 27-hydroxylase; Cholesterol 24-hydroxylase; Cholesterol 25-hydroxylase; Oxysterol 7α-hydroxylase; 24-hydroxycholesterol 7α-hydroxylase; Epigene
The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats
Keywords: شرکای کوچک همجنسگرا; Asbt; apical sodium-dependent bile acids transporter; ALP; alkaline phosphatase; ALT; alanine transaminase; AST; aspartate transaminase; BAs; bile acids; Bsep/BSEP; bile salt export pump; β-MCA; β-muricholic acid; CA; cholic acid; CDCA; chenodeoxycholic
Ubiquitination/sumoylation: An alternative pathway to modify gene regulation directed by xenosensors
Keywords: شرکای کوچک همجنسگرا; Epigenetic regulation; Post-translational modifications; Nuclear receptors; Xenobiotics metabolism; AHR; aryl hydrocarbon receptor; AHRR; aryl hydrocarbon receptor repressor; ARNT; aryl hydrocarbon receptor nuclear translocator; CAR; constitutive androsta
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
Keywords: شرکای کوچک همجنسگرا; Farnesoid X receptor; TGR5; Atherosclerosis; Obesity; NAFLD; α-Sma; alpha smooth muscle actin (α-Sma); BA; bile acid; BAT; brown adipose tissue; CEBPα; CCAAT/enhancer-binding protein α; Col1α1; collagen type 1 α1; DIO; diet-induced obesity; FXR; far
ApoE is a major determinant of hepatic bile acid homeostasis in mice
Keywords: شرکای کوچک همجنسگرا; ApoE; apolipoprotein E; BA; bile acid; HCHF; high-cholesterol/high-fat liver; Lrh; receptor homolog-1; Srebp1; sterol regulatory element-binding protein; Shp; small heterodimer partner; MCA; muricholic acid; CDCA; chenodeoxycholic acid; MRM; multiple reac
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: شرکای کوچک همجنسگرا; NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation
Keywords: شرکای کوچک همجنسگرا; Glycogen synthase kinase 3 beta; AMP-activated protein kinase; Macrophage; Small heterodimer partner; Inflammation; Ischaemia-reperfusion injury; Toll-like receptor; IL-10;
E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice
Keywords: شرکای کوچک همجنسگرا; bZip; the basic leucine zipper; CAR; constitutive androstane receptor; Ces/CES; mouse and human carboxylesterases; ChIP; chromatin immunoprecipitation assay; Co-IP; co-immunoprecipitation; CYP7A1; cholesterol 7alpha-hydroxylase; DMEM; Dulbecco's modifie
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
Keywords: شرکای کوچک همجنسگرا; Biliary excretion; PPARα; Bile acids; Gender difference; 1oBAs; Primary bile acids; 2oBAs; secondary bile acids; 12-OH; 12-hydroxylated bile acid; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; Baat; bile acid CoA:amino acid N-acyltr
Maternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny
Keywords: شرکای کوچک همجنسگرا; RCT; Reverse cholesterol transport; LXRα; Liver X-receptor alpha; CpG islands; CG-dinucleotide-rich regions in the gene promoter; HDL; High-density lipoproteins; PPAR; Peroxisome proliferator-activated receptor; SRB-1; Scavenger Receptor class B, member
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: شرکای کوچک همجنسگرا; Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand
Keywords: شرکای کوچک همجنسگرا; CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; LCA; litocholic acid; BAs; bile acids; BARS; bile acid activated receptors; GPBAR1; G protein coupled bile acid receptor; TGR5; Takeda G protein receptor 5; FXR; farnesoid x-receptor; PX
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: شرکای کوچک همجنسگرا; Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: شرکای کوچک همجنسگرا; NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP)
Keywords: شرکای کوچک همجنسگرا; DEC1; BHLHE40; SHP; NR0B2; Circadian rhythm; AMPK; 5â² AMP-activated protein kinase; Bmal1; Brain and muscle ARNT-like 1; Clock; circadian locomotor output cycles kaput; Cry; Cryptochrome; CYP7A1; Cytochrome P450 enzyme cholesterol 7α-hydroxylase; DEC;
Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists
Keywords: شرکای کوچک همجنسگرا; FXR; farnesoid X receptor; CDCA; chenodeoxycholic acid; CYP7A1; cholesterol 7α-hydroxylase; SHP; small heterodimer partner; RXRα; retinoid X receptor α; 9-cis-RA; 9-cis-retinoic acid; LBD; ligand binding domain; TR-FRET; time-resolved fluorescence reso
Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver
Keywords: شرکای کوچک همجنسگرا; ASBT; apical sodium-dependent bile salt transporter; BSEP; bile salt export pump; COX2; cyclooxygenase 2; CYP7A1; cholesterol 7α-hydroxylase; FXR; farnesoid X receptor; HFHC; high fat and high cholesterol; HMGCR; 3-hydroxy-3-methyl glutaryl coenzyme A re
The interrelationship between bile acid and vitamin A homeostasis
Keywords: شرکای کوچک همجنسگرا; ATGL; Adipose triglyceride lipase; ADH; Alcohol dehydrogenase; ALD; Alcoholic liver disease; atRA; All-trans retinoic acid; ASBT/SLC10A2; Apical sodium-dependent bile salt transporter; ABCA1; ATP-binding cassette transporter member 1; BCMO1; Beta-carotene
Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis
Keywords: شرکای کوچک همجنسگرا; ACE2; angiotensin I converting enzyme 2; AGT; angiotensinogen; ATI; alveolar epithelial cells type I; ATII; alveolar epithelial cells type II; BALF; bronchial alveolar lavage fluid; BMP2; bone morphogenetic protein 2; BMPR1A; bone morphogenetic protein re
Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells
Keywords: شرکای کوچک همجنسگرا; Human iPS cells; Enterocyte-like cells; CYP3A4 induction; Nuclear receptor; CDX2; caudal type homeobox 2; CYP3A4; cytochrome P450 3A4; DEX; dexamethasone; EGF; epidermal growth factor; FGF2; fibroblast growth factor 2; FXR; farnesoid X receptor; GR; gluco
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats
Keywords: شرکای کوچک همجنسگرا; ALT; alanine amiotransferase; ANIT; alpha-naphthylisothiocyanate; AST; aspartate transaminase; BIL; bilirubin; Bsep; bile salt export pump; CMC-Na; carboxymethylcellulose sodium; E3S; estrone-3-sulfate; FXR; Farnesoid X receptor; IS; hydrochlorothiazide;
Pleiotropic effects of antitumour alkylphospholipids on cholesterol transport and metabolism
Keywords: شرکای کوچک همجنسگرا; ABCA1; ATP-binding cassette transporter isoform A1; APL; alkylphospholipid; apoA1; apolipoprotein A1; CETP; cholesteryl ester transfer protein; CYP7A1; cholesterol 7α-hydroxylase; CYP27; sterol 27-hydroxylase; DHCR7; 7-dehydrocholesterol reductase; ER; e
Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes
Keywords: شرکای کوچک همجنسگرا; ANIT; alpha-naphthylisothiocyanate; A1AR; A1 adenosine receptor; FXR; farnesoid X receptor; SHP; small heterodimer partner; Bsep; bile salt export pump; Mrp2; multidrug resistance-associated protein 2; Ntcp; Na+-dependent taurocholate cotransporter; Oatp2
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies
Keywords: شرکای کوچک همجنسگرا; FXR; farnesoid X receptor; HDX-MS; hydrogen deuterium exchange mass spectrometry; MetS; metabolic syndromes; SHP; small heterodimer partner; BSEP; bile salt export pump; LBD; ligand binding domain; XN; xanthohumol; IX; isoxanthohumol; 8-PN; 8-prenylnarige
The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4
Keywords: شرکای کوچک همجنسگرا; FLU; flutamide; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-MC; 3-methylcholanthrene; ABCC4; ATP-binding cassette sub-family C member 4; MRP4; mul
miRNA and cholesterol homeostasis
Keywords: شرکای کوچک همجنسگرا; miRNA; microRNA; SREBP; sterol regulatory element-binding protein; SCAP; SREBP cleavage-activating protein; Ago; Argonaute family protein; RISC; RNA-induced-silencing-complex; Fbxw7; F-box and WD repeat domain containing 7; NAFLD; non-alcoholic fatty live
Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
Keywords: شرکای کوچک همجنسگرا; ABC; ATP-binding cassette transporter; AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase; AhR; arylhydrocarbon receptor; AKR1C1; aldo-keto reductase 1C1; APO; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BAs; bile acids; BSEP; b
Nanoencapsulated curcumin and praziquantel treatment reduces periductal fibrosis and attenuates bile canalicular abnormalities in Opisthorchis viverrini-infected hamsters
Keywords: شرکای کوچک همجنسگرا; OV; Opisthorchis viverrini; CCA; cholangiocarcinoma; NEC; nanoencapsulated curcumin; PZQ; praziquantel; PDF; periductal fibrosis; BC; bile canaliculi; Cur; curcumin; ALT; alanine transaminase; MMP; matrix metalloproteinases; TIMP; tissue inhibitors of MMP
Investigation of the dominant positive effect of porcine farnesoid X receptor (FXR) splice variant 1
Keywords: شرکای کوچک همجنسگرا; CAR; constitutive androstane receptor; PXR; pregnane X receptor; FXR; farnesoid X receptor; CYP3A4; cytochrome P450 3A4; SULT2A1; hydroxysteroid sulfotransferase; UGT2B4; UDP-glucuronosyltransferase 2B4; GRβ; glucocorticoid receptor β; ERE; estrogen res
Research ArticleHepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner
Keywords: شرکای کوچک همجنسگرا; NAFLD; Non-alcoholic fatty liver disease; ERα; estrogen receptor α; FXR; farnesoid X receptor; SHP; small heterodimer partner; TG; Triglyceride; LXR; liver X receptor; ERβ; estrogen receptor β; HFD; High-Fat Diet; SREBP-1c; sterol regulatory element b
Research ArticleThyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis
Keywords: شرکای کوچک همجنسگرا; BA; bile acid; TSH; thyroid-stimulating hormone; TSHR; thyroid-stimulating hormone receptor; TH; thyroid hormone; TR; thyroid hormone receptor; FXR; farnesoid X receptor; SHP; small heterodimer partner; LRH-1; liver receptor homologue-1; PXR; pregnane X r
Sensitization to autoimmune hepatitis in group VIA calcium-independent phospholipase A2-null mice led to duodenal villous atrophy with apoptosis, goblet cell hyperplasia and leaked bile acids
Keywords: شرکای کوچک همجنسگرا; AB-PAS; alcian blue-periodic acid schiff; AIH; autoimmune hepatitis; ALT; alanine aminotransferase; AP; alkaline phosphatase; AST; aspartate aminotransferase; Bcl-2; B-cell lymphoma 2; CA; cholic acid; CCL; chemokine ligand; CCR; chemokine receptor; CDCA;
Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice
Keywords: شرکای کوچک همجنسگرا; Nuclear Receptor; Circadian Regulation; Metabolism; Liver Disease Model; BHMT; betaine-homocysteine S-methyltransferase; CTH; cystathionine γ-lyase; CTRL; control; EtOH; ethanol; FOXA1; forkhead box A1; Hcy; homocysteine; HHcy; hyperhomocysteinemia; LD;
1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose
Keywords: شرکای کوچک همجنسگرا; ERR; estrogen-related receptor; WAT; white adipose tissue; BAT; brown adipose tissue; PET; positron-emission-tomography; FGF21; fibroblast growth factor 21; MOA; mechanisms of action; UCP1; uncoupling protein 1; SHP; small heterodimer partner; ATP5b; ATP
Retinoic acid regulates several genes in bile acid and lipid metabolism via upregulation of small heterodimer partner in hepatocytes
Keywords: شرکای کوچک همجنسگرا; RA, retinoic acid; SHP, small heterodimer partner; AML12, alpha mouse liver 12; VAD, vitamin A deficient; TTNPB, 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acidRetinoic acid; Small heterodimer partner; AML12 cell l
Activation of farnesoid X receptor induces RECK expression in mouse liver
Keywords: شرکای کوچک همجنسگرا; FXR; farnesoid X receptor; RXRα; retinoid X receptor α; SHP; small heterodimer partner; SREBP-1c; sterol regulatory element-binding protein-1c; PEPCK; phosphoenolpyruvate carboxykinase; RECK; reversion-inducing cysteine rich protein with Kazal motifs; M
Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease
Keywords: شرکای کوچک همجنسگرا; FXR; farnesoid X receptor; ALD; alcoholic liver disease; SHP; small heterodimer partner; BSEP; bile salt export pump; CYP7A1; cholesterol 7α-hydroxylase; CYP8B1; sterol 12α-hydroxylase; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; CYP2E1; c
Research ArticleAltered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease
Keywords: شرکای کوچک همجنسگرا; SBS; short bowel syndrome; SBS-ALD; short bowel syndrome-associated liver disease; PN; parenteral nutrition; SBR; small bowel resection; BA; bile acid; FXR; farnesoid X receptor; SHP; small heterodimer partner; FGF19; fibroblast growth factor 19; CYP7A1;
Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders
Keywords: شرکای کوچک همجنسگرا; Inflammation; Cytochrome P450; Epoxygenase; Epoxyeicosatrienoic acids; Variability; AA; arachidonic acid; AhR; aryl hydrocarbon receptor; AP-1; activator protein-1; bZIP; basic leucine zipper; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR r