Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man
Keywords: ابرمتن سوتی; Mutagenesis; E. coli; p53; Somatic hypermutation; Kinetic models
مقالات ISI ابرمتن سوتی (ترجمه نشده)
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The role of B lymphocytes in the progression from autoimmunity to autoimmune disease
Keywords: ابرمتن سوتی; B lymphocytes; Antigen presentation; Epitope spreading; Somatic hypermutation; Class switch; Regulatory B cells
Immunoglobulin Gene Rearrangements and Mutational Status in Argentinian Patients With Chronic Lymphocytic Leukemia
Keywords: ابرمتن سوتی; Chronic lymphocytic leukemia; Fluorescence in situ hybridization; Immunoglobulin heavy chain variable gene; Somatic hypermutation; Stereotyped B-cell receptor;
The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia
Keywords: ابرمتن سوتی; CLL; Immunoglobulin gene; CDR3; Antigen; Somatic hypermutation; Stereotype; Subset;
Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity
Keywords: ابرمتن سوتی; Ataxia telangiectasia; class switch recombination; somatic hypermutation; κ-deleting recombination excision circle; hypogammaglobulinemia; B-cell subsets; T-cell subsets; AT; Ataxia telangiectasia; ATM; Ataxia telangiectasia mutated; DSB; Double-strand b
Somatic hypermutation of TCR γ V genes in the sandbar shark
Keywords: ابرمتن سوتی; T cell receptor; Somatic hypermutation; Adaptive immune system; Evolution; Shark;
AIDing antibody diversity by error-prone mismatch repair
Keywords: ابرمتن سوتی; Mismatch repair; Class switch recombination; Somatic hypermutation; Activation-induced deaminase; Double-strand breaks; Cytosine deamination; Epigenetic; Antibody diversity
Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
Keywords: ابرمتن سوتی; Haemophilus influenzae; infections; immunoglobulins; IgM; immunodeficiency; AID; Activation-induced deaminase; BTK; Bruton tyrosine kinase; CD40L; CD40 ligand; HIgM; Hyper-IgM; NTHi; Nontypeable Haemophilus influenzae; PHG; Panhypogammaglobulinemia; RR; R
Mutational Status and Gene Repertoire of IGHV-IGHD-IGHJ Rearrangements in Serbian Patients With Chronic Lymphocytic Leukemia
Keywords: ابرمتن سوتی; B-cell receptor; Gene use; Immunoglobulin heavy variable genes; Somatic hypermutation; VH CDR3
Somatic hypermutation leads to diversification of the heavy chain immunoglobulin repertoire in cattle
Keywords: ابرمتن سوتی; Cattle; Immunoglobulin diversity; Heavy chain locus; Somatic hypermutation
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA
Keywords: ابرمتن سوتی; AID; activation-induced cytidine deaminase; AP; apurinic/apyrimidinic; BER; base excision repair; CSR; class-switch recombination; ESI-MS; electrospray ionization mass spectrometry; HIGM syndrome; hyper-IgM syndrome; LCL; lymphoblastoid cell line; MALDI-T
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase
Keywords: ابرمتن سوتی; PCNA; RAD5; HLTF; SHPRH; Somatic hypermutation; Translesion synthesis
Insights into the B cell specific process of immunoglobulin class switch recombination
Keywords: ابرمتن سوتی; BCR; B cell receptor; CSR; class switch recombination; Ig; immunoglobulin; SHM; somatic hypermutation; GC; germinal center; C; constant; S; switch; DSBs; double strand breaks; DDR; DNA damage response; NES; nuclear-export sequence; c-NHEJ; Canonical non h
Mismatch-mediated error prone repair at the immunoglobulin genes
Keywords: ابرمتن سوتی; Mismatch repair; Class switch recombination; Somatic hypermutation; AID; DSB; Epigenetic; Antibody diversity
The zebrafish IgH locus contains multiple transcriptional regulatory regions
Keywords: ابرمتن سوتی; IgH; immunoglobulin heavy chain; SH; somatic hypermutation; MAR; matrix attachment region; Transcription; Immunoglobulin; Enhancer; Zebrafish; VDJ recombination; IgZ; IgT;
Unlocking the secrets of immunoglobulin receptors in mantle cell lymphoma: Implications for the origin and selection of the malignant cells
Keywords: ابرمتن سوتی; Mantle cell lymphoma; Immunoglobulin genes; Somatic hypermutation; CDR3; Antigen selection;
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance
Keywords: ابرمتن سوتی; PCNA; Polη; Somatic hypermutation; Translesion synthesis; DNA damage tolerance; Ubiquitination;
The little brown bat, M. lucifugus, displays a highly diverse VH, DH and JH repertoire but little evidence of somatic hypermutation
Keywords: ابرمتن سوتی; Heavy chain variable region; Repertoire; Somatic hypermutation; Bats; Phylogeny
Genesis of ancestral haplotypes: RNA modifications and reverse transcription-mediated polymorphisms
Keywords: ابرمتن سوتی; Polymorphic frozen block; Somatic hypermutation; SNP clusters; RT-mediated gene conversion; Transcription-coupled repair; Transcription factories;
Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break
Keywords: ابرمتن سوتی; Activation-induced deaminase; AID; Base excision repair; Somatic hypermutation; Double-strand breaks; Mutagenesis
The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated
Keywords: ابرمتن سوتی; Somatic hypermutation; p53; AID; Ig genes; Knockout mice; pol eta; pol iota
The germinal center reaction
Keywords: ابرمتن سوتی; Germinal center; antibody response; B-cell differentiation; somatic hypermutation; affinity maturation; B-cell migrationAID, Activation-induced cytidine deaminase; BCL-6, B-cell lymphoma 6; CD40L, CD40 ligand; CSR, Class-switch recombination; EBI2, Epstei
The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody
Keywords: ابرمتن سوتی; aa, amino acid; CDR 3H, third CDR of H chain; NP, (4-hydroxy-3-nitrophenyl)acetyl; PC, phosphocholine; phOx, 2-phenyl oxazolone; SHM, somatic hypermutation; W33L, mutation from Trp to Leu at position 33Antibody; Affinity maturation; Somatic hypermutation;
Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases
Keywords: ابرمتن سوتی; Germinal center; Somatic hypermutation; Immunoglobulin (Ig); Autoimmune diseases; Rheumatoid Arthritis (RA); Multiple Sclerosis (MS); Sjögren’s Syndrome (SS)AA, amino acid; AI, autoimmune; AID, Activation-induced cytidine deaminase; BCR, B cell receptor;
Wot the ‘L—Does MutL do?
Keywords: ابرمتن سوتی; MutL; MutS; Mismatch repair; Nucleotide excision repair; Base excision repair; Somatic hypermutation; Apoptosis
SHMTool: A webserver for comparative analysis of somatic hypermutation datasets
Keywords: ابرمتن سوتی; Somatic hypermutation; Mutation analysis; Standardization
Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion
Keywords: ابرمتن سوتی; GC; germinal center; Ig; immunoglobulin; SHM; somatic hypermutation; AID; activation-induced cytidine deaminase; NP-CGG; 4-hydroxy-3-nitrophenyl-acetyl coupled to chicken gamma-globulin; LPS; lipopolysaccharide; Tg; thymine glycol; 8-oxoG; 8-oxoguanine; F
Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: Molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patterns
Keywords: ابرمتن سوتی; Chronic lymphocytic leukemia; Small lymphocytic lymphoma; Cytogenetics; Fluorescence in situ hybridization; IgV genes; Somatic hypermutation; 14q32/IGH
Antisense transcripts of V(D)J rearrangements; artifacts caused by false priming?
Keywords: ابرمتن سوتی; Immunoglobulin; Somatic hypermutation; AID; Transcription; Antisense
Possible contribution of DNase γ to immunoglobulin V gene diversification
Keywords: ابرمتن سوتی; Somatic hypermutation; Immunoglobulin variable region; Double-strand DNA breaks; Endonucleases; DNase γ;
Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma
Keywords: ابرمتن سوتی; Follicular lymphoma; Immunoglobulin; Kappa light chains; Somatic hypermutation
Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia
Keywords: ابرمتن سوتی; B-cell chronic lymphocytic leukemia; TP53; FASAY; Somatic hypermutation; Activation-induced cytidine deaminase;
AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene
Keywords: ابرمتن سوتی; Somatic hypermutation; Gene conversion; Immunoglobulin; DT40
The kappa immunoglobulin light chain repertoire of peripheral blood B cells in patients with juvenile rheumatoid arthritis
Keywords: ابرمتن سوتی; JRA; juvenile rheumatoid arthritis; JIA; juvenile idiopathic arthritis; EOPA; early-onset pauciarticular arthritis; RAG; recombination activating gene; TdT; terminal deoxynucleotide transferase; SHM; somatic hypermutation; RA; rheumatoid arthritis; SLE; s
Distinctive IgVH gene segments usage and mutation status in Chinese patients with chronic lymphocytic leukemia
Keywords: ابرمتن سوتی; Chronic lymphocytic leukemia; Immunoglobulin heavy chain gene; Somatic hypermutation; CD38 antigen; ZAP-70
EBV transformation overrides gene expression patterns of B cell differentiation stages
Keywords: ابرمتن سوتی; EBV; B cells; Viral transformation; LCL; Gene expression; Somatic hypermutation; Lymphoma pathogenesis
II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation
Keywords: ابرمتن سوتی; Somatic hypermutation; DNA secondary structures; Transcription; VH genes; Computer model;
Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney
Keywords: ابرمتن سوتی; Activation-induced DNA cytosine deaminase; Somatic hypermutation; Class switch recombination; Immunoglobulin; Transgenic mice
Anti-peripherin B lymphocytes are positively selected during diabetogenesis
Keywords: ابرمتن سوتی; B cell; BCR; Antibody; Immunoglobulin genes; Autoantibody; Somatic hypermutation; Receptor revision; Receptor edition; Secondary rearrangement; Type 1 diabetes; Autoimmune disease; NOD mouse
I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
Keywords: ابرمتن سوتی; Somatic hypermutation; Transcription-directed mutagenesis; Secondary structures; Supercoiling;
Brca1 in immunoglobulin gene conversion and somatic hypermutation
Keywords: ابرمتن سوتی; Brca1; Gene conversion; Somatic hypermutation; Immunoglobulin gene; DT40 cells
Mutagenic roles of DNA “repair” proteins in antibody diversity and disease-associated trinucleotide repeat instability
Keywords: ابرمتن سوتی; Somatic hypermutation; Trinucleotide repeat instability; Mismatch repair; Huntington's disease; Class switch recombination; Myotonic dystrophy
Potential inhibition of somatic hypermutation by nucleoside analogues
Keywords: ابرمتن سوتی; Somatic hypermutation; Nucleoside analogues; Human immunodeficiency virus; Affinity maturation;
Neural logic molecular, counter-intuitive
Keywords: ابرمتن سوتی; Creative thinking; Boolean logic gates; Molecular mechanism; Transcription regulation; Somatic hypermutation; Neuron
The cellular origin of mantle cell lymphoma
Keywords: ابرمتن سوتی; CCND1; Immunoglobulin; Somatic hypermutation; Chromosomal translocation; NFKB; mTOR
Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
Keywords: ابرمتن سوتی; Somatic hypermutation; AID; Immunoglobulin; Class switch recombination; Mismatch repair; B cells; Burkitt lymphoma; Translesion synthesis;
Class switch recombination: A friend and a foe
Keywords: ابرمتن سوتی; Class switch recombination; Switch regions; Somatic hypermutation; Genetic instability; Translocation; Activation-induced deaminase; Germline transcription; DNA repair
The nuclear DNA deaminase AID functions distributively whereas cytoplasmic APOBEC3G has a processive mode of action
Keywords: ابرمتن سوتی; AID; activation induced cytidine deaminase; hAID; human activation induced cytidine deaminase; Ig; immunoglobulin; SHM; somatic hypermutation; CSR; class-switch recombination; GC; gene conversion; ung; uracil N-glycosylase; MBP; maltose binding protein; W
AID mutates a non-immunoglobulin transgene independent of chromosomal position
Keywords: ابرمتن سوتی; Activation-induced cytidine deaminase; Somatic hypermutation; Immunoglobulin; Antibody; Affinity maturation
Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations
Keywords: ابرمتن سوتی; EBV; Somatic hypermutation; AID; Error-prone DNA polymerases; BCL-6; p53; Oncogene; B lymphocyte; Lymphoma