miR-125b regulates procalcitonin production in monocytes by targeting Stat3
Keywords: Procalcitonin; miR-125b; Stat3; Sepsis; LPS; Monocyte
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Parthenolide ameliorates Concanavalin A-induced acute hepatitis in mice and modulates the macrophages to an anti-inflammatory state
Keywords: Parthenolide; Acute hepatitis; Macrophage; STAT3;
Rosmarinic Acid suppressed high glucose-induced apoptosis in H9c2 cells by ameliorating the mitochondrial function and activating STAT3
Keywords: Rosmarinic Acid; Cardiomyocyte; High-glucose; Mitochondrial injury; Apoptosis; STAT3;
The importin protein karyopherin-β1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor
Keywords: Rheumatoid arthritis; KPNB1; STAT3; IL-1β; Fibroblast-like synoviocytes;
Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation
Keywords: Salvia plebeia; Lamiaceae; Eudesmane sesquiterpenoids; IL-6; STAT3; Inflammation;
JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total BÂ cells
Keywords: JAK inhibitor; Adjuvant-induced arthritis; Th17; Treg; Memory BÂ cells; STAT3;
Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3
Keywords: Psoriasis; Regulatory T cells; STAT3; Pro-inflammatory cytokines
Methylene blue alleviates experimental autoimmune encephalomyelitis by modulating AMPK/SIRT1 signaling pathway and Th17/Treg immune response
Keywords: MS; multiple sclerosis; MB; methylene blue; EAE; experimental autoimmune encephalomyelitis; CNS; central nervous system; IFN; interferon; NF-κB; nuclear factor kappa B; AMPK; AMP-activated protein kinase; SIRT1; silent mating-type information regulation
17β-estradiol exerts anticancer effects in anoikis-resistant hepatocellular carcinoma cell lines by targeting IL-6/STAT3 signaling
Keywords: Hepatocellular carcinoma; 17β-estradiol; Interleukin-6; STAT3; Drug resistance; Aniokis resistance; EMT; HCC; Hepatocellular carcinoma; AR; Anoikis-resistant; E2; 17β-estradiol; IL-6; Interleukin-6; STAT3; Signal transducer and activator of transcriptio
Caveolin-1 Mediates Low-Intensity Ultrasound-Induced Apoptosis via Downregulation of Signal Transducer and Activator of Transcription 3 Phosphorylation in Laryngeal Carcinoma Cells
Keywords: Low-intensity ultrasound; Caveolin-1; Apoptosis; STAT3;
Cytotoxic T Lymphocyte Antigen-4 Down-Regulates T Helper 1 Cells by Increasing Expression of Signal Transducer and Activator of Transcription 3 in Acute Graft-versus-Host Disease
Keywords: Cytotoxic T lymphocyte antigen 4; T helper 1 cell; STAT3; Acute graft-versus-host disease;
p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling
Keywords: PAK4; Pancreatic cancer; Stemness; STAT3; Sphere formation; Chemoresistance;
Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes
Keywords: TBK1/IKKε; IKK; NF-κB; Stat3; HTLV-1 Tax; T lymphocyte transformation;
MicroRNAs: New regulators of IL-22
Keywords: IL-22; interleukin-22; Th22; T helper 22 cell; Th1; T helper 1 cell; Th17; T helper 17 cell; NK22; natural killer 22; NKT; natural killer T cell; ILCs; innate lymphoid cells; RORγt; retinoid orphan receptor γt; STAT3; signal transducer and activator of
4-Carbonyl-2,6-dibenzylidenecyclohexanone derivatives as small molecule inhibitors of STAT3 signaling pathway
Keywords: Curcumin; STAT3; Inhibitors; Antitumor; Apoptosis;
Inflammation as a driver and vulnerability of KRAS mediated oncogenesis
Keywords: KRAS; Inflammation; NF-κB; STAT3; Cytokines; Autophagy;
A-type lamin-dependent homo-oligomerization for pY19-Caveolin-2 to function as an insulin-response epigenetic regulator
Keywords: ER; endoplasmic reticulum; PM; plasma membrane; Cav-2; Caveolin-2; INM; inner nuclear membrane; STAT3; signal transducer and activator of transcription 3; PTP1B; protein tyrosine phosphatase 1B; H3K9me3; histone H3 lysine 9 trimethylation; H3K9ac; histone
The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations
Keywords: STAT3; Head and neck cancer
Interaction of a small molecule Natura-α and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis
Keywords: Inhibitor; STAT3; Phosphorylation; Computational modeling; Lupus; NZB/W mice
Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system
Keywords: sRAGE; soluble receptor for advanced glycation end-products; I/R; Ischemia/Reperfusion; UPS; Ubiquitin proteasome system; LAD; Left anterior descending coronary artery; STAT; Signal transducer and activator of transcription; RAGE; Receptor for advanced gl
Rapamycin Decreases the Osteogenic Response in Aortic Valve Interstitial Cells Through the Stat3 Pathway
Keywords: ALP; alkaline phosphatase; AVICs; aortic valve interstitial cells; BMP-2; bone morphogenetic protein 2; CAVD; calcific aortic valve disease; LPS; lipopolysaccharide; mTOR; mammalian target of rapamycin; RUNX2; runt-related transcription factor 2; Stat3; s
Delayed wound healing and dysregulation of IL6/STAT3 signalling in MSCs derived from pre-diabetic obese mice
Keywords: Interleukin-6; Mesenchymal stem cells; Diabetes; Obesity; STAT3
Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling
Keywords: Cryptotanshinone; Adipogenesis; C/EBPβ; PPARγ; STAT3; CT; cryptotanshinone; RA; retinoic acid; Tro; troglitazone; C/EBP; CCAAT/enhancer-binding protein; PPARγ; peroxisome proliferation-activity receptor γ; GAPDH; glycerol-3-phosphate dehydrogenase; IB
Ovarian cancer stem-like cells differentiate into endothelial cells and participate in tumor angiogenesis through autocrine CCL5 signaling
Keywords: Ovarian cancer; Cancer stem cell; CCL5; Angiogenesis; Endothelial cell differentiation; CSCs; cancer stem cells; CSLCs; cancer stem-like cells; ECs; endothelial cells; VEGF; vascular endothelial growth factor; HUVECs; human umbilical vein endothelial cell
GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3 signalling
Keywords: Perinatal; Hypoxia-ischaemia; GSK3β; STAT3; Neuroinflammation; Oxidative stressHI, hypoxia-ischaemia; GSK3β, glycogen synthase kinase 3β; STAT3, signal transducer and activator of transcription; PND, postnatal day; glcl, γglutamyl cysteine ligase catalyti
Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade
Keywords: Gemcitabine; CSC; STAT3; ROS; NF-κB;
Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells
Keywords: Atmospheric particulate matter (PM10); STAT3; p21Waf1/Cip1; Src kinase; PKCζ kinase;
Hypothyroidism advances mammary involution in lactating rats through inhibition of PRL signaling and induction of LIF/STAT3 mRNAs
Keywords: PRL signaling pathway; Nuclear receptors; STAT3; LIF; Caspases; Tissue remodelingprlr, Prolactin receptor mRNA; stat5a/stat5b/stat3, STAT5a/STAT5b/STAT3 mRNAs; STAT5a/b, STAT5a/b protein; socs1/socs3/cis, SOCS1/SOCS3/CIS mRNAs; lif, LIF mRNA; erα/erβ, Est
Hyper-IgE Syndromes and the Lung
Keywords: Hyper-IgE syndromes; Pulmonary manifestations; Job syndrome; DOCK8 deficiency; PGM3 deficiency; STAT3;
Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway
Keywords: Arsenic trioxide; Microglia; STAT3; P38/JNK MAPK; IL-1β
Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma
Keywords: OSCC; Oral Squamous Cell Carcinoma; miRNA; MicroRNA; NGS; Next Generation Sequencing; STRING; Search Tool for Retrieval of Interacting Genes/Proteins; ACTREC; Advanced Centre for Treatment Research and Education in Cancer; HNOCDB; Head Neck Oral Cancer Da
IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment
Keywords: HCC; hepatocellular carcinoma; IL-6; interleukin-6; STAT3; Signal transducer and activator of transcription 3; PCAF; P300/CBP-associated factor; HATs; histone acetyltransferases; ELISA; enzyme-linked immunosorbent assay; Co-IP; co-immunoprecipitation; ChI
Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement
Keywords: Cytokine; IL-6; Cancer stem cell; Chemoresistance and EMT; MAPK; mitogen-activated protein kinases; STAT3; signal transducer and activator of transcription 3; gp130; glycoprotein 130; C/EBP; CCAAT/enhancer-binding protein; JAK; Janus kinase; PI3K; phospho
Targeting transcription factor STAT3 for cancer prevention and therapy
Keywords: STAT3; Cancer; Cytokines; Proliferation; Apoptosis; AngiogenesisCML, chronic myelogenous leukemia; DBD, DNA-binding domain; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; FGFR, fibroblast growth factor receptor; HNSCC, head and neck
Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells
Keywords: Resveratrol; STAT3; Squamous cell carcinoma of the head and neck; SOCS-1ECL, enhanced chemiluminescence; HRP, horseradish peroxidase; ICC, immunocytochemistry; JAK, Janus tyrosine kinase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;
Research ArticleLong non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis
Keywords: HCC; hepatocellular carcinoma; lncRNA; long non-coding RNA; lnc-DILC; lncRNA downregulated in liver cancer stem cells; LCSC; liver cancer stem cell; IL-6; interleukin-6; STAT3; signal transducer and activator of transcription 3; NF-κB; nuclear factor kap
Phosphorylated heat shock protein 27 promotes lipid clearance in hepatic cells through interacting with STAT3 and activating autophagy
Keywords: Hsp27 phosphorylation; Autophagy; Hepatic steatosis; STAT3;
IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3
Keywords: IRAK-M; Toll-like receptors; Wnt signaling; STAT3; microbiome; colorectal cancer
TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Keywords: Apoptosis; Cytokines; iNOS; STAT3; TRAF2; Type 1 diabetes;
STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury
Keywords: CNTF; Ciliary neurotrophic factor; CSPG; Chondroitin sulfate proteoglycan; DAPI; 4â²,6-Diamidino-2-phenylindole; EdU; 5-Ethynyl-2â²-deoxyuridine; GFAP; Glial fibrillary acidic protein; JAK; Janus kinase; LIF; Leukemia inhibitory factor; NG2; Neural glia
A novel bisindole-PBD conjugate inhibits angiogenesis by regulating STAT3 and VEGF in breast cancer cells
Keywords: Angiogenesis; Bisindole-PBD (5b); VEGF; STAT3; Breast cancer; CAM assay;
Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism
Keywords: CCL2; MCP-1; DRG; Regeneration; Macrophage; Neuroinflammation; STAT3
STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration
Keywords: STAT3; Pax7; muscle satellite cells; muscle regeneration; self-renewal; dystrophin; fibrosis
Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis
Keywords: TGF-β; transforming growth factor β; IL-6; interleukin-6; STAT3; signal-transducer and activator of transcription; RORα; retinoid acid-related orphan receptor α; ICAM-1; intercellular adhesion molecule-1; MCP-1; monocyte chemoattractant protein-1; PGE
Feedback Activation of STAT3 as a Cancer Drug-Resistance Mechanism
Keywords: STAT3; activation; inhibitor; drug-resistance; cancer
Epigallocatechin gallate and mitochondria-A story of life and death
Keywords: ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; ALT; alanine aminotransferase; AMP; adenosine monophosphate; AP-1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; ATP; adenosine triphosphate; Bax; BCL2-Associated X Protein; Bc
Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways
Keywords: ELR; Glu-Leu-Arg; GPCRs; G protein-coupled receptors; NFκB; nuclear factor κB; STAT3; signal transducer and activator of transcription 3; MEM; minimum essential media; FLIPR; fluorometric imaging plate reader; G protein-coupled receptors; CXCL8; interle
Essential role of HDAC6 in the regulation of PD-L1 in melanoma
Keywords: Histone deacetylases; HDAC6; PD-L1; STAT3; PP2A; Melanoma; Nexturastat; Tubastatin A;
Transgenic mice with increased astrocyte expression of IL-6 show altered effects of acute ethanol on synaptic function
Keywords: Synaptic plasticity; EEG; Gamma frequency; Glia; Ethanol withdrawal hyperexcitability; Neuroimmune; STAT3; Long-term potentiation;