Design, synthesis and evaluation of XZH-5 analogues as STAT3 inhibitors
Keywords: STAT3; Inhibitor; SARs; SH2; Small organic molecule; Molecular docking
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Mutations leading to constitutive active gp130/JAK1/STAT3 pathway
Keywords: Inflammatory hepatocellular adenomas; gp130; STAT3; FRK; GNAS; JAK1; HCA; hepatocellular adenoma; IHCA; inflammatory HCA; HCC; hepatocellular carcinoma; STATs; ignal transducer and activator of transcription; JAK; Janus kinase; LGL; large granular lymphoc
Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer
Keywords: PKM1; PKM2; STAT3; LPS; Inflammation; Proliferation;
Research ArticleDysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling
Keywords: miRNA; microRNA; 3â² UTR; 3â² untranslated region; mRNA; messenger RNA; IL-6; interleukin-6; STAT3; signal transducer and activator of transcription 3; PCR; polymerase chain reaction; PCNA; proliferating cell nuclear antigen; GAPDH; glyceraldehyde 3-pho
Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis
Keywords: IL-6 family cytokines; Atherosclerosis; ApoE; Gp130; STAT3;
Treatment of IL-21R-Fc control autoimmune arthritis via suppression of STAT3 signal pathway mediated regulation of the Th17/Treg balance and plasma B cells
Keywords: Autoimmune arthritis; IL-21R-Fc; STAT3; Th17; Plasma cell
IL-6, IL-10, c-Jun and STAT3 expression in B-CLL
Keywords: B-CLL; IL-6; IL-10; c-Jun; STAT3
STAT3-dependent VEGF production from keratinocytes abrogates dendritic cell activation and migration by arsenic: A plausible regional mechanism of immunosuppression in arsenical cancers
Keywords: Arsenic; Dendritic cells; VEGF; Keratinocytes; Bowen’s disease; STAT3
Dynamic control of Th2 cell responses by STAT3 during allergic lung inflammation in mice
Keywords: STAT3; Allergic asthma; Th2 cell; Th17 cell; Th1 cell
Involvement of fish signal transducer and activator of transcription 3 (STAT3) in nodavirus infection induced cell death
Keywords: RGNNV; STAT3; Autophagy; Necrotic cell death; Viral replication
Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carcinoma (ESCC) cells via suppression of PI3K/AKT and Stat3 pathways
Keywords: ESCC; Dasatinib; Cisplatin; AKT; Stat3
Research ArticleRole for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses
Keywords: IRE1α; inositol-requiring enzyme 1α; ER; endoplasmic reticulum; CCl4; carbon tetrachloride; PH; partial hepatectomy; UPR; unfolded protein response; LKO; liver specific IRE1α knockout; IL-6; interleukin 6; STAT3; signal transducer and activator of tran
Knockdown of STAT3 expression in SKOV3 cells by biodegradable siRNA-PLGA/CSO conjugate micelles
Keywords: siRNA-PLGA conjugates; STAT3; Chitosan oligosaccharide (CSO); Micelles; Gene knockdown;
Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells
Keywords: Hepatoma; SK-Hep 1 cells; NFκB; Morusin; STAT3; Tumor progression;
PRDX6 promotes tumor development via the JAK2/STAT3 pathway in a urethane-induced lung tumor model
Keywords: PRDX6; JAK2; STAT3; Lung cancer; GPx; iPLA2; Free radicals;
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
Keywords: Colorectal cancer; Cancer stem cell; Wnt signaling; Traf2- and Nck-interacting kinase (TNIK); Molecular targeting therapy; ABC; ATP-binding cassette; APC; adenomatous polyposis coli; CBP; cAMP response element binding protein (CREB)-binding protein; CK; c
A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development
Keywords: N-acetyl-l-cysteine (NAC) (PubChem CID: 12035); AKT; protein kinase B; AP-1; activator protein 1; CCL2; chemokine (C-C motif) ligand 2; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; FFA; free fatty acid; GLUT; gluc
Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid
Keywords: STAT3; 14-3-3epsilon; Alzheimer's disease; Amyloid beta peptides; Microglia; ac-STAT3(K685); acetylated form of STAT3 on Lys685 residue; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid beta peptides; CCL5; chemokine (C-C motif) lig
MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer
Keywords: Pancreatic cancer; Cancer stem cells; miR-1181; SOX2; STAT3;
Single nucleotide polymorphisms of the NF-κB and STAT3 signaling pathway genes predict lung cancer prognosis in a Chinese Han population
Keywords: Single nucleotide polymorphism; lung cancer; prognosis; NF-κB; STAT3
Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer
Keywords: STAT3; NSCLC; Small molecule inhibitors;
The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes
Keywords: Skin cancer; Inflammation; STAT3; Mir-21; Molecular mechanism
CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer
Keywords: Gastric cancer; Angiogenesis; Prognosis; CXCL1; VEGF; STAT3
Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock
Keywords: Tyrphostin AG490 (PubChem CID: 5328771)RANTES; IL-6; IL-12; iNOS; STAT3; pSTAT3
S-nitrosoglutathione-mediated STAT3 regulation in efficacy of radiotherapy and cisplatin therapy in head and neck squamous cell carcinoma
Keywords: S-Nitrosoglutathione; STAT3; NF-κB; Head and neck cancer; Radiotherapy; Cisplatin
Cyclophilin D and myocardial ischemia-reperfusion injury: A fresh perspective
Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; ATP5G; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); BAK; BCL2-antagonist/killer; BAX; BCL2-associated X protein; BCL-2; B cell lymphoma protein 2; C1QBP
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway
Keywords: ATG4d; autophagy-related gene 4d; ATG6; autophagy-related gene 6; ATG12; autophagy-related gene 12; BAX; BCL-2 Associated X Protein; BCL-2; B-cell lymphoma-2; BW; body weight; Bet; piglets born to sows supplemented with betaine diets; CCND2; cyclin D2; Co
Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer
Keywords: Cancer; Interleukin; IL-6; IL-11; STAT3;
Sex differences in the relationship of IL-6 signaling to cancer cachexia progression
Keywords: IL-6r; STAT3; SOCS3; Skeletal muscle; ApcMin/+;
Potent inhibitory effect of terpenoids from Acanthopanax trifoliatus on growth of PC-3 prostate cancer cells in vitro and in vivo is associated with suppression of NF-κB and STAT3 signalling
Keywords: Chemoprevention; NF-κB; Prostate cancer; STAT3; TerpenoidsFBS, foetal bovine serum; IHC, immunohistochemical; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NF-κB, nuclear factor-κB; PI, propidium iodide; SCID, severe combined immunode
Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice
Keywords: T cells; SLE; STAT3; Murine lupus; MRL/lpr;
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling
Keywords: Apoptosis; Hepatocellular carcinoma; Flavonoids; STAT3; P.âamplexicaule; Polygonum amplexicaule D. Don var. sinense Forb; HCC; hepatocellular carcinoma; TFPA; total flavonoids from P. amplexicaule; STAT3; signal transducer and activator of transcription
Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension
Keywords: 5HT; 5-hydroxytryptamine; ACh; acetylcholine; BP; blood pressure; DBP; diastolic blood pressure; Emax; maximum possible effect; Jak-2; janus kinase-2; l-NAME; N-nitro-l-arginine methyl ester; MAP; mean arterial pressure; NOS; nitric oxide synthase; Phe; p
Hippocampal dynamics of synaptic NF-kappa B during inhibitory avoidance long-term memory consolidation in mice
Keywords: ANOVA; analysis of variance; AP-1; activator protein 1; C/EBP; CCAAT-enhancer-binding proteins; CREB; cAMP response element-binding protein; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; ELK-1; ETS domain-containing protein Elk-1; EMSA; elec
Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells
Keywords: CRC; Mutation; Cytokine; EMAST; STAT3; Tetranucleotide RepeatCRC, colorectal cancer; ELISA, enzyme-linked immunosorbent assay; EMAST, elevated microsatellite alterations at selected tetranucleotide repeats; FBS, fetal bovine serum; gp130, glycoprotein 130
Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells
Keywords: STAT3; Alantolactone; Sesquiterpene lactone; MDA-MB-231 cells; Triple-negative breast cancer (TNBC);
Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease
Keywords: Annexin-A1; Th17; Autoimmune; STAT3; SOCS3; UveitisAnx-A1, Annexin-A1; EAU, experimental autoimmune uveoretinitis; RBP, retinoid-binding protein
Cigarette smoke–induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway
Keywords: Abdominal aortic aneurysm; Matrix metalloproteinase; Cigarette smoke; Jak2; Stat3
Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3
Keywords: Abdominal aortic aneurysm; Toll-like receptor 4; STAT3; Angiotensin II;
TIPE2 protein prevents injury-induced restenosis in mice
Keywords: TNFAIP8L2 (TIPE2); Vascular smooth muscle cell; Restenosis; Rac1; STAT3;
Activation of Wnt/β-catenin signaling in Muller glia protects photoreceptors in a mouse model of inherited retinal degeneration
Keywords: Neuroprotection; Wnt; Stat3; Retina; Muller glia;
Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors
Keywords: STAT3; Small-molecule inhibitor; Aminotetrazole; Anticancer drug; Inflammation; STAT; signal transducer and activation of transcription; SH2; Src Homoly 2; Th; T helper; OSM; oncostatin M; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;
Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-κB signaling
Keywords: Ursolic acid; Osteoclastogenesis; NF-κB; Titanium particle; Osteolysis; AP-1; activator protein-1; BV/TV; bone volume/tissue volume; BMD; bone mineral density; BMC; bone mineral content; BMMs; bone marrow monocytes; CK; cathepsin K; CT; computed tomograp
Effects of angiotensin II on leptin and downstream leptin signaling in the carotid body during acute intermittent hypoxia
Keywords: ACE; angiotensin I converting enzyme; ANG II; angiotensin II; AT1R; angiotensin type-1 receptor; AT2R; angiotensin type-2 receptor; Capt; captopril; EDTA; ethylenediaminetetraacetic acid; ERK1/2; extracellular-signal-regulated kinase 1/2; IH; acute interm
Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways
Keywords: Akt; ERK1/2; IL-2; Piperine; STAT3; STAT5; T lymphocyte
ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca2 + overload and contractile dysfunction via the JAK2/STAT3 pathway
Keywords: Reactive oxygen species; Intracellular Ca2 + concentration; STAT3; Bcl-2; SR Ca2 +-ATPase 2; Intermittent hypobaric hypoxia
Tetrandrine suppresses human glioma growth by inhibiting cell survival, proliferation and tumour angiogenesis through attenuating STAT3 phosphorylation
Keywords: Tetrandrine; Glioma; Apoptosis; Proliferation; Angiogenesis; CAM; STAT3
Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha
Keywords: CNTF(R); Ciliary neurotrophic factor (receptor); EGF; Epidermal growth factor; ERK; Extracellular signal-regulated kinase; FRα; Folate receptor alpha; GPI; glycophosphatidylinositol; IFN; Interferon; IL-6(R); Interleukin 6 (receptor); ISG; Interferon sti
Redox regulation of metabolic and signaling pathways by thioredoxin and glutaredoxin in NOS-3 overexpressing hepatoblastoma cells
Keywords: ACO; aconitase; ASK1; apoptosis signal-regulating kinase 1; Bcl-2; B-cell lymphoma 2; CaM; calmodulin; CD95; cluster of differentiation 95; DTNB; 5,5-dithio-bis-2-nitrobenzoic acid; ELISA; enzyme-linked immunosorbent assay; GAPDH; glyceraldehyde-3-phospha
Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)
Keywords: STAT3; Transcription factors; Small molecule inhibitors; Anticancer drugs; Cancer therapy; Mechanism of action; Computational modeling; Molecular dynamic simulation; Site-directed mutagenesis;