Keywords: هشدار سازه; Mechanisms of toxic action; Classification; Ecotoxicology; Mammalian toxicology; Structural alerts; Decision tree; Modes of Action;
مقالات ISI هشدار سازه (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: هشدار سازه; Carcinogen classes; Functional groups; Molecular fragments; Structural alerts; Structure–activity relationships; Carcinogenicity prediction
Keywords: هشدار سازه; Metabolic activation; Reactive metabolite; Cytochrome P450; Drug-induced toxicity; Structural alerts
N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity
Keywords: هشدار سازه; CCR10; CCL27; Psoriasis; Contact hypersensitivity; Structural alerts;
A new integrated in silico strategy for the assessment and prioritization of persistence of chemicals under REACH
Keywords: هشدار سازه; REACH; Registration, Evaluation, Authorisation and restriction of CHemicals; P; persistent; nP; non-persistent; vP; very persistent; nP/P; non-persistent/persistent; P/vP; persistent/very persistent; HL; half-lives; DT50; disappearance time 50; PBT; persi
Integrated in silico strategy for PBT assessment and prioritization under REACH
Keywords: هشدار سازه; REACH; Registration, Evaluation, Authorisation and Restriction of Chemicals; (Q)SAR; (quantitative) structure-activity relationship; ECHA; European Chemicals Agency; UBA; Umweltbundesamt; MCDM; multi-criteria decision making; WoE; weight of evidence; AD;
A comparative survey of chemistry-driven in silico methods to identify hazardous substances under REACH
Keywords: هشدار سازه; QSARs; Read-across; Structural alerts; Applicability domain; Consensus; Cost-efficiency; PBT; CMR; Endocrine disruption; Skin sensitisation;
Mutagenic impurities in pharmaceuticals: A critique of the derivation of the cancer TTC (Threshold of Toxicological Concern) and recommendations for structural-class-based limits
Keywords: هشدار سازه; Threshold of Toxicological Concern derivation; Carcinogenic potency; False carcinogens; Linear extrapolation; Structural alerts; Mutagenic impurities in pharmaceuticals; Structural-class-based limits;
INTEGRATION OF QSAR AND SAR METHODS FOR THE MECHANISTIC INTERPRETATION OF PREDICTIVE MODELS FOR CARCINOGENICITY
Keywords: هشدار سازه; Counter propagation artificial neural network; mechanistic interpretation of model; carcinogenicity; (quantitative) structure-activity relationships; structural alerts; Toxtree application; Dragon descriptors; Kohonen maps; non-congeneric chemicals
Development of new structural alerts suitable for chemical category formation for assigning covalent and non-covalent mechanisms relevant to DNA binding
Keywords: هشدار سازه; Chemical category formation; Structural alerts; In silico profiler; Covalent DNA binding; Non-covalent DNA binding; Read-across;
Forced degradation of fentanyl: Identification and analysis of impurities and degradants
Keywords: هشدار سازه; Fentanyl; Forced degradation; Degradants; Impurities; Validation; Structural alerts
Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds : Species: Rat; Sex: Male; Route of administration: Water
Keywords: هشدار سازه; Nitroso-compounds; TOPS-MODE; Carcinogenicity; Structural alerts
An evaluation of the sensitivity of the Ames assay to discern low-level mutagenic impurities
Keywords: هشدار سازه; Genotoxic impurity; Synthetic intermediate; Mutagen; Carcinogen; Genotoxicity; Genetic safety; Structural alerts; Structure activity relationship (SAR)
Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds
Keywords: هشدار سازه; Nitroso-compounds; TOPS-MODE; Carcinogenicity; Structural alerts
The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development
Keywords: هشدار سازه; Genotoxic impurities; Structure–activity relationship; Synthetic intermediates; Structural alerts; Genetic safety; Mutagens; Carcinogens; Analytical measurement; Process control