دانلود مقالات ISI درباره T-L + ترجمه فارسی

مهارکننده های نسل بعد پروتئازوما برای درمان سرطان

Next-generation proteasome inhibitors for cancer therapy

Keywords: BTZ; bortezomib; CFZ; carfilzomib; C-L; caspase-like; CNS; central nervous system; CT-L; chymotrypsin-like; CYPs; cytochrome P450 enzymes; iP; immunoproteasome; IXZ; ixazomib; MM; multiple myeloma; OPZ; oprozomib; PD; pharmacodynamic; PI; proteasome inhib

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

مهارکننده های ایمونو پروتئازوم-انتخابی و غیر انتخابی: یک رویکرد امیدوار کننده برای درمان بیماری های مختلف میلوما

Immunoproteasome-selective and non-selective inhibitors: A promising approach for the treatment of multiple myeloma

Keywords: AE; Adverse event; BIPN; Bortezomib-induced peripheral neuropathy; C-L; Caspase-like; CFZ; Carfilzomib; ChT-L; Chymotrypsin-like action; IRd; Ixazomib, lenalidomide, and dexamethasone; LG; Leaving group; MM; Multiple myeloma; MTD; Maximum tolerated dose;

دانلود رایگان متن کامل مقاله ISI 77 صفحه سال انتشار : 2018 سفارش ترجمه

فعال سازی پروتئازوم سبب افزایش ساقه و عمر سلول های بنیادی مزانشیمی انسان می شود

Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells

Keywords: MSC; Mesenchymal Stem Cell; hMSC; human Mesenchymal Stem Cell; WJ; Wharton's Jelly; ASC; Adipose Stem Cell; CPDs; Cumulative Population Doublings; CT-L; Chymotrypsin-Like; T-L; Trypsin Like; PGPH; Peptidylglutamyl-peptide hydrolyzing; ROS; Reactive Oxygen

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

شناسایی مهارکننده های پروتئازوم غیر غربالگری با انتخاب انتخابی بالا برای فعالیت های مشابه چیوتریپسین با استفاده از یک غربالگری مجازی مبتنی بر ساختار چند مرحله ای

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening

Keywords: Proteasome inhibitors; Non-covalent; Peptide scaffold; Docking studies; Virtual screening; AMC; 7-amino-4-methylcoumarin; ChT-L; chymotrypsin-like; DMSO; dimethylsulfoxide; HMBC; Heteronuclear multi-bond correlations; HSQC; Heteronuclear single-quantum co

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

توسعه بورونات پپتیوودیمتیک به عنوان مهار کننده های پروتئازوم

Development of peptidomimetic boronates as proteasome inhibitors

Keywords: Peptidomimetic boronates; Proteasome inhibitors; Docking studies; ChT-L; chymotrypsin-like; T-L; trypsin-like; PGPH; post-glutamyl peptide hydrolyzing; DMSO; dimethyl sulfoxide; DMF; dimethylformamide; Pd2(dba)3; tris(benzylideneacetone)dipalladium; EDC;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism stud

Keywords: SAR; structureactivity relationship; UPP; ubiquitinproteasome pathway; FDA; Food and Drug Administration; ATP; Adenosine triphosphate; CP; core particle; RP; regulatory proteasome; C-L; caspase-like; T-L; trypsin-like; CT-L; chymotrypsin-like; EDCI; 1-eth

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy

Keywords: UPS; ubiquitin-dependent protein degradation pathway; CP; proteasome core particle; BrAAP; branched chain amino acid-preferring activity; T-L; trypsin-like activity; ChT-L; chymotrypsin-like activity; Caspase-like activity; peptidyl-glutamyl-peptide-hydro

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

New C4- and C1-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: Evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform

Keywords: DMF DMA; dimethylformamide dimethylacetal; DMSO; dimethylsulfoxide; c20S; 20S constitutive proteasome catalytic core; i20S; immunoproteasome catalytic core; CT-L; chymotrypsin-like; T-L; trypsin-like; PA; post-acid or caspase-like; AMC; 7-amino-4-methyl-c

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Proteasome activation delays aging in vitro and in vivo

Keywords: UPS; ubiquitin-proteasome system; PGPH; peptidyl glutamyl peptide hydrolyzing; T-L; trypsin-like; CT-L; chymotrypsin-like; AD; Alzheimer disease; PD; Parkinson disease; HD; Huntington disease; AMD; age-related macular degeneration; ALS; amyotrophic late

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2014 سفارش ترجمه

C1 and N5 derivatives of cerpegin: Synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome

Keywords: DMF/DMA; dimethylformamide/dimethylacetal; DMSO; dimethyl sulfoxide; 20S; 20S proteasome catalytic core; CT-L; chymotrypsin-like; T-L; trypsin-like; PA; post-acid or caspase-like; AMC; 7-amino-4-methyl-coumarin; ®-NA; ®-naphthylamide; PDB; Protein Data

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Crosstalk between the ubiquitin-proteasome system and autophagy in a human cellular model of Alzheimer's disease

Keywords: AβPP; amyloid-β precursor protein; Aβ40; amyloid-β (1-40); Aβ42; amyloid-β (1-42); UPS; ubiquitin-proteasome system; HDAC6; histone deacetylase 6; ChT-L; chymotrypsin-like; T-L; trypsin-like; PGPH; peptidylglutamyl-peptide hydrolyzing; AP-N; a

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes

Keywords: ChT-L; chymotrypsin-like; PGPH; peptidyl-glutamyl peptide hydrolyzing; T-L; trypsin-like; BrAAP; branched chain amino acid preferring; SNAAP; small neutral amino acid preferring; Ub; Ubiquitin; ThT; Thioflavin T; AP-N; Aminopeptidase-N; Suc; succinyl; p

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Wheat sprout extract induces changes on 20S proteasomes functionality

Keywords: 20S proteasome; Wheat sprout extract; Antioxidant; Polyphenol; Caco cells; 12-O-tetradecanoylphorbol-13-acetate; AE; ellagic acid; AG; gallic acid; AMC; 7-amino-4-methyl-coumarin; AP-N; aminopeptidase-N; BrAAP; branched chain amino acid preferring; C; (+)

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

HDAC inhibition prevents NF-κB activation by suppressing proteasome activity: Down-regulation of proteasome subunit expression stabilizes IκBα

Keywords: SCFA; short chain fatty acid; HDAC; histone deacetylase; NF-κB; nuclear factor-κB; IκB; inhibitor-κB; IKK; IκB kinase; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; BA; butyrate; TSA; trichostatin A; CT-L; chymotrypsin-like; T-L; trypsyn

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه