دانلود مقالات ISI درباره تاکرین + ترجمه فارسی

Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease

Keywords: تاکرین; OLKLOVAJULLISR-UHFFFAOYSA-N; WUZJRHKAIFSDMM-UHFFFAOYSA-N; XKKFXCKMPXLPKK-UHFFFAOYSA-N; WKAJCZZPMZGMDI-UHFFFAOYSA-N; ZXEXKQSBZMYPAQ-UHFFFAOYSA-N; UTSQNVLOMVPCIW-YTTGMZPUSA-N; LBOYVYBBAFDIGX-NDEPHWFRSA-N; HLSFNIKGKKTOIA-TWAVRPEISA-N; HSQBZWURRKNSMR-TXMUIZFD

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3′,4′:5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase

Keywords: تاکرین; Alzheimer's disease; Coumarin; Tacrine; Cholinesterase inhibitor; Docking study;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2013 سفارش ترجمه

NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity

Keywords: تاکرین; Alzheimer’s disease; Butyrylcholinesterase inhibitors; Tacrine; Nitric oxide; Vasodilator properties

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Preparation and optimization of chitosan nanoparticles and magnetic chitosan nanoparticles as delivery systems using Box–Behnken statistical design

Keywords: تاکرین; Chitosan nanoparticles; Experimental design; Particle size optimization; DR-FTMIR spectrometry; Tacrine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Tacrine can suppress immune response to tularemia in BALB/c mouse model

Keywords: تاکرین; inflammation; infection; Alzheimer disease; tacrine; acetylcholinesterase; innate immunity

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors

Keywords: تاکرین; Tacrine; Lophine; Four component reaction; Indium trichloride; AChE inhibitory activity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

A novel series of tacrine–selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease

Keywords: تاکرین; Tacrine; Selegiline; Cholinesterase inhibitor; Monoamine oxidase inhibitor; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Investigation of the role of linker moieties in bifunctional tacrine hybrids

Keywords: تاکرین; Acetylcholinesterase; Alzheimer’s disease; Bifunctional molecules; Mefenamic acid; Tacrine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Multifunctional tacrine–flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease

Keywords: تاکرین; Alzheimer's disease; Flavonoid; Tacrine; Cholinesterase; β-Amyloid aggregation; Metal chelatorJBVVLTRVHVGZEU-UHFFFAOYSA-N; JWCIYSMFMZTUME-UHFFFAOYSA-N; LESFBJPJZADQHL-UHFFFAOYSA-N; PDCBHYYTMYMYBE-UHFFFAOYSA-N; SXDGSJQISGFVLK-UHFFFAOYSA-N; DAQOTHBGIZARGM-U

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

Keywords: تاکرین; Tacrine; Bis(7)tacrine; Alzheimer’s disease; MTDL; Cystamine-tacrine dimer; Oxidative injury

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats

Keywords: تاکرین; Tacrine; Hydroxytacrine; Pharmacokinetics; Brain disposition; Fluorescence

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease

Keywords: تاکرین; Alzheimer's disease; Tacrine; AChE/BChE inhibitors; Amyloid; Molecular modelingAD, Alzheimer's disease; Aβ, amyloid β-protein; NFT, neurofibrillary tangles; AChEIs, acetylcholinesterase inhibitors; AChE, acetylcholinesterase; ACh, acetylcholine; THA, 9-am

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents

Keywords: تاکرین; Tacrine; Alzheimer's disease; Cholinesterase; Antioxidant; β-Amyloid;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors

Keywords: تاکرین; Tacrine; Alzheimer's disease (AD); Acetylcholinesterase; Butyrylcholinesterase; HPLC validation; 4-Fluoroacetic acid

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine

Keywords: تاکرین; AChE, acetylcholinesterase; HRMS, high resolution mass spectrometry; AD, Alzheimer's disease; CYP, cytochrome P450; AMQ, 7-acetoxy-1-methyl-quinolinium iodide; HMQ, 7-hydroxy-1-methyl-quinolinium productOn-line acetylcholinesterase bioassay; Tacrine; LC–M

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia

Keywords: تاکرین; Diencephalic amnesia; Septohippocampal pathway; Acetylcholine; Tacrine; (Rat)

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine

Keywords: تاکرین; Tacrine; Chitosan nanoparticles; Alzheimer's disease; Biodistribution

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones

Keywords: تاکرین; Acridines; Tacrine; AChE inhibitory activity

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by KV4.2 expressed in Xenopus oocyte

Keywords: تاکرین; Bis(7)-tacrine; Tacrine; KV4.2 encoded potassium channel; A-type K+ channel; Xenopus oocyte; Dorsal root ganglion; Rat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Rapid determination of tacrine and other drug metabolites in microsomal incubate by newly developed targeting algorithm on UHPLC/TOFMS

Keywords: تاکرین; High-throughput; UHPLC/TOFMS; Tacrine; Targeting algorithm; Cytochrome P450

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: A potential mechanism underlying its anti-parkinsonian tremor effect

Keywords: تاکرین; Zonisamide; Tremor; Tacrine; c-Fos; Parkinson's disease

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Significant delivery of tacrine into the brain using magnetic chitosan microparticles for treating Alzheimer's disease

Keywords: تاکرین; Alzheimer's disease; Tacrine; Magnetic chitosan microparticles; Targeted drug delivery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration

Keywords: تاکرین; Acetylcholine; Acetylcholinesterase inhibitors; Cocaine; Self-administration; Reinforcement (Psychology); Tacrine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Effects of zonisamide on experimental tremors in rats

Keywords: تاکرین; Zonisamide; Tremor; Harmaline; Tacrine; Parkinson's disease

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Tacrine based human cholinesterase inhibitors: Synthesis of peptidic-tethered derivatives and their effect on potency and selectivity

Keywords: تاکرین; Cholinesterases; Alzeheimer’s disease; Inhibitors; Tacrine

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

Keywords: تاکرین; Tacrine; Ferulic acid; Cholinesterase inhibitor; Antioxidant; Anti-Alzheimer drug; Hybrid molecule

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice

Keywords: تاکرین; Antioxidant; Tacrine; Donepezil; Passive Avoidance test; Morris water maze

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Development of an in vitro drug–drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds

Keywords: تاکرین; CYP, cytochrome P450; DDI, drug–drug interaction; LC/MS–MS, liquid chromatography/tandem mass spectrometry; MeCN, Acetonitrile; DMSO, dimethylsulfoxide; SE, standard error; SD, standard deviation.Assay; Cytochrome P450; Tacrine; (S)-mephenytoin; Dextromet

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles

Keywords: تاکرین; Brain targeting; Blood–brain barrier; Tacrine; Nanoparticles; Poly(n-butylcyanoacrylate)

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain

Keywords: تاکرین; Memantine; Donepezil; Tacrine; Neurotoxicity; Vacuoles; NMDA antagonist; Cholinergic; Glutamatergic; Cell killing; Excitotoxic; Dendrotoxic

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2008 سفارش ترجمه

Alkylene tether-length dependent γ-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

Keywords: تاکرین; GABAA receptor; Acetylcholinesterase; Tacrine; Bis(7)-tacrineGABA, γ-aminobutyric acid; NMDA, N-methyl-d-aspartate; AChE, acetylcholinesterase; BChE, butyrylcholinesterase; DMSO, dimethyl sulfoxide; DRG, dorsal root ganglion; DMEM, Dulbecco's modified Eag

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes

Keywords: تاکرین; Hepatocytes; Gel entrapment; Hollow fibers; Tacrine; Hepatotoxicity; CYP 1A2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Quantitative structure–activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity using variable selections

Keywords: تاکرین; Tacrine; Multiple linear regression (MLR); RV criterion; Quantitative structure–activity relationship (QSAR); Acetylcholinesterase (AChE)

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine

Keywords: تاکرین; Tacrine; Acetylcholinesterase inhibitor; PAF antagonist; Oxidative injury; Inflammation; Macrophages

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease

Keywords: تاکرین; Parkinson; Tremor; A2A antagonists; Tacrine; Pilocarpine; Striatum

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals

Keywords: تاکرین; Tacrine; Pyrano[2,3-b]quinolines; Inhibitors; AChE; BuChE; Neuroprotection; Voltage-dependent calcium channels (VDCC); Alzheimer's disease; Multipotent drugs

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Memory-dependent novelty-related location preferences: Sex-related attenuation of forgetting by d-glucose and tacrine

Keywords: تاکرین; Novelty preferences; Glucose; Tacrine; Memory; Forgetting; Sex differences

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Alzheimer's disease drugs promote neurogenesis

Keywords: تاکرین; Alzheimer's disease; Neurogenesis; Tacrine; Galantamine; Memantine; Bromodeoxyuridine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice

Keywords: تاکرین; Tacrine; Passive-avoidance response; Open-field memory; Locomotor; Defecation; Acute toxicity; Hepatotoxicity; Developmental changes;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Inhibition of two different cholinesterases by tacrine

Keywords: تاکرین; Tacrine; Cholinesterase; Snake venom; Human serum

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties

Keywords: تاکرین; Extrapyramidal side effects; Parkinsonism; Tacrine; Tremulous jaw movements; 5-HT1A agonist; Antipsychotic;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Effects of (±)-huprine Y and (±)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

Keywords: تاکرین; Alzheimer's disease; AChE inhibitor; Huperzine A; Tacrine; (±)-Huprine Y; (±)-Huprine Z; Muscarinic receptors;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه

Donepezil–tacrine hybrid related derivatives as new dual binding site inhibitors of AChE

Keywords: تاکرین; Acetylcholinesterase inhibitors; Tacrine; Donepezil; Alzheimer’s disease

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Selective cortical VGLUT1 increase as a marker for antidepressant activity

Keywords: تاکرین; Vesicular glutamate transporter; Expression regulation; Cortex; Hippocampus; Antidepressants; Antipsychotics; Mood disorders; Memantine; Tacrine; Haloperidol; Diazepam;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Economics of dementia and pharmacoeconomics of dementia therapy

Keywords: تاکرین; Alzheimer's diseas; cholinesterase inhibitor; dementia; donepezil; galantamine; memantine; pharmacoeconomics; rivastigmine; tacrine;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Cholinergic drugs potentiate human nicotinic α4β2 acetylcholine receptors by a competitive mechanism

Keywords: تاکرین; Human nicotinic acetylcholine receptor; Galanthamine; Scopolamine; Tacrine; Xenopus laevis oocyte; Two-microelectrode voltage clamp;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Validation of the tremulous jaw movement model for assessment of the motor effects of typical and atypical antipychotics: effects of pimozide (Orap) in rats

Keywords: تاکرین; Schizophrenia; Extrapyramidal; Tacrine; Cognex; Tremor; Parkinson;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه